Protein Alignment XRCC5 and Ku80

DIOPT Version :10

• Sequence 1: XP_054199770.1
• Gene: XRCC5 / 7520
• HGNCID: 12833
• Length: 827
• Species: Homo sapiens
• Sequence 2: NP_609767.2
• Gene: Ku80 / 34930
• FlyBaseID: FBgn0041627
• Length: 699
• Species: Drosophila melanogaster
• Alignment Length: 733
• Identity: 160/733 - (21%)
• Similarity: 298/733 - (40%)
• Gaps: 131/733 - (17%)

Human    99 SGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTDGTDNPL 163
            :.||..:::.:||....:..:.      .::.|.:...::.::..:.||.::.||.|.| ||...
  Fly     2 ASNKECLIIVLDVRTCAAEEVK------LKSAKCVAEILKDKIVCDRKDYVSFVLVGCD-TDEIK 59

Human   164 SGGDQYQNITVHRHLMLPDFD-LLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHI 227
            :....:.|:.......|..:. |||..:...:...:..::|:.|..::: :|:.....:..:|.|
  Fly    60 TEDASHPNVLPFGEPRLCSWQLLLEFFQFVNKTACEDGEWLNGLQAALE-LQNVATTLRVARRRI 123

Human   228 -------------EIFTDLSSRFSKSQLDIII--HSLKKCDISL----QFFLPFSLGKEDGSGDR 273
                         |.|.:::.......:::|:  |::...|.::    |....||         |
  Fly   124 LLLFDFNDFPQDYEKFNEITDELLGENIELIVGTHNIAYIDNAITSQPQAIFNFS---------R 179

Human   274 GDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIERH 338
            ..||..|             ..||..|.:|.....:|         .||.|:|.  .|||...|.
  Fly   180 KCGPDEL-------------NNQKYALSLVPRCNATL---------CSFKEALH--TVFKVTNRR 220

Human   339 SIHWPCRLTIGSNLSIR---IAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEV 400
            ...|..:|.|||.:||.   |.|.|:....::.|.|..      |.|.:.:||.:.:...:.|.
  Fly   221 PWVWNAKLNIGSKISISLQGIIAMKNQTPVKLVKVWAE------KDEIVIRETRHYIKGTEITP- 278

Human   401 LKEDIIQGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDD 465
            |.|::|.|:..|...||:.:...|..:....|..|  .||.|.:.|...:|.|..:..:...:.:
  Fly   279 LPENLITGYMLGGTPVPYDEAVLEPKEPHPPGLHF--FGFIKRNAVPDEYFCGESLYLLVHQKHN 341

Human   466 EAAAVALSSLIHALDDLDMVAIVRYAYDKRAN-PQVGVAFPHIKHNYE--CLVYVQLPFMEDLRQ 527
            ::|||.|.:|:.||...|...:....|..:.| ||:.|..|.:..:..  .|..:::.:......
  Fly   342 QSAAVKLDALVRALVSSDRAILCWKIYSTKFNRPQMVVLLPRLADDTHPATLYMLEVSYTSQHHF 406

Human   528 YMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKT--DTLE-------DLFPTTKIPNPRFQ 583
            :.|.:|:.:|... :|.||||:|.||||..|    |.|  ||.:       ||.|...:|:...|
  Fly   407 WDFPALRTTKTEC-SEEQLNAIDQLIDSTDL----ECTLRDTQQPRPWAQNDLLPFDALPSIFEQ 466

Human   584 RLFQCLLHRALHPREPLPPIQQH------IWNMLNPPAEVTTKSQIPLSKIKTLFPLIEAKK-KD 641
            .:...|..:.::..:....:.:.      .|.:.:|..|   ||:...:.:|.||||..::. ::
  Fly   467 NVMDILERKVIYDNDKEDKMLKDKNFADVFWRVPDPLEE---KSKRAAAIVKKLFPLRYSRAWQE 528

Human   642 QVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNPAENF-RVLVK------- 698
            ::.|:|    ..|:|...|....|:     .:...::|    ||.::|..:| |||..
  Fly   529 KLLAKE----QAENGVAVKSEPAEK-----EIPLPSDG----VGLIDPISDFRRVLASVHTISNA 580

Human   699 -QKKASFEEASNQLINHIEQFLDTNETPYFMKSI----DCIRAFREEAIKFSEEQRFNNFLKALQ 758
             ::.|.|:..:......|...|...:     ::|    :.|..:|:..|.|:....::.|.:.|:
  Fly   581 TERDARFQALAADTRVVIITLLQRRK-----QNIGQLGELITLYRQSCIDFNTFLEYDKFAEELK 640

Human   759 EKVEIKQLNHFWEIVVQD 776
            :....|..:.||:.|:.|
  Fly   641 KIALAKNRSEFWQDVMVD 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XRCC5	XP_054199770.1	Ku_N	104..339	CDD:427470	46/254 (18%)
		KU80	339..638	CDD:238445	82/319 (26%)
		Ku_PK_bind	688..801	CDD:462604	21/102 (21%)
Ku80	NP_609767.2	Ku_N	7..213	CDD:427470	42/246 (17%)
		KU80	221..524	CDD:238445	82/319 (26%)
		Ku_PK_bind	562..>659	CDD:462604	21/102 (21%)