Protein Alignment XRCC5 and pku80

DIOPT Version :10

• Sequence 1: XP_054199770.1
• Gene: XRCC5 / 7520
• HGNCID: 12833
• Length: 827
• Species: Homo sapiens
• Sequence 2: NP_596791.1
• Gene: pku80 / 2541045
• PomBaseID: SPBC543.03C
• Length: 695
• Species: Schizosaccharomyces pombe
• Alignment Length: 762
• Identity: 166/762 - (21%)
• Similarity: 295/762 - (38%)
• Gaps: 160/762 - (20%)

Human   101 NKAAVVLCMDVGFTMSNSIPG-IESPFEQAKKVITMFVQRQVFAENK-DEIALVLFGTDGTDNPL 163
            :|...|..:|:|..|.....| ..|..|.........:..:..|..| |.:.:|.:..|.|.|.|
pombe     3 DKECTVFVLDLGKDMGTCHHGRSHSDLEWTLSYFHDELSHKFLANRKTDVVGIVGYKCDDTKNDL 67

Human   164 SGGDQYQNITVHRHLMLPDFDLLEDIESKIQP-GSQQADFLDALIVSMDVIQHETIGKKFEKRHI 227
            :..:.|.||:|...:....|..|:.:...::| .:.|.|.:.|::||.|::.......|::|:.|
pombe    68 AEQEAYWNISVLYPIQTALFSKLQSVSQTLKPSNTMQGDLISAIVVSFDLMARHCKKNKWKKKMI 132

Human   228 EIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSF----- 287
             :.|........|....|...|.:.|:.                        ||.:|..|
pombe   133 -VLTAARGIIDFSDYIGIAEQLLQHDVF------------------------LGVYGVDFDQEDI 172

Human   288 ----PLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLR-KLCVFKKIERH-SIHWPCRL 346
                |||   |.||:..|:               .|..|.||.. :.|.|::|..: ...|..::
pombe   173 NYSEPLK---ESQKKENEV---------------RIQEFVESCHGQYCTFQQIYNNIGKPWVRKV 219

Human   347 ----------TIG------SNLSIRIAAY-----------KSILQERVKKTW-------TVVDAK 377
                      :||      :::||::..|           .:..:..:.|.:       :.|:.|
pombe   220 RPVAIFRGTFSIGNRDSKDTSISIQVERYPRTRLTKPPTSSAFYENDMSKNYECLNIENSNVENK 284

Human   378 TLKKEDIQKETVYCLND---DDETEVLKEDIIQGFRYGSDIVPFSKVDEEQMKYKS-EGKCFSVL 438
            :::.:.:.....|.:.|   :|..||.:||:..|:.||..|||.|:.||:.:...: .|  :.:|
pombe   285 SMESDAVSTVRSYMVRDPKTNDSFEVKREDLESGYSYGRTIVPISRSDEDVLALDTIPG--YEIL 347

Human   439 GFCKSSQVQRRFFMGNQVLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVA 503
            ||...|.:...:.:.:  ..:...:||..:.:..|:.:.:|:.....|:.|:....:..|.:.|.
pombe   348 GFIPKSSLPIYYTISD--TNIIVPKDDFESKLNFSAFVQSLEREHRYALARFVSKDKGVPVLLVL 410

Human   504 FPHIKHNYECLVYVQLPFMEDLRQYMFS---SLKNSKKYAPTEAQLNAVDALIDSMSLAKKD--- 562
            .|:::.....||.:||||.||:|.|.||   .|.|.:.....:.   ||...||:|.|...|
pombe   411 MPYVEFKRHYLVDIQLPFAEDVRPYSFSEFEKLSNEEDMRQIDF---AVSNYIDNMDLDSSDCGF 472

Human   563 ----EKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPAEVTTKSQI 623
                |..:|.      :.||:    ||.|.:.:.|..|...||....::....|||..:.....:
pombe   473 NPPFEPENTF------SMIPH----RLQQAISYYANSPEGDLPQPNIYLTRYTNPPKSLLDNCIL 527

Human   624 PLSKIKTLFPLIEAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSL-------AEGS- 680
            .|..||... .:....|.:.::||...|      |...:..||      :..|       .||.
pombe   528 DLKLIKEKL-TVNVPVKPKYSSQETAFD------TGAPISEEQ------IEELLNSGLDEQEGEK 579

Human   681 --VTSVGSVNPAENFRVLVKQKKASFEEASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIK 743
              |..|...:|...|..::| .....|:|..::...|:..:|.::....::|:..:|.   .:|.
pombe   580 LLVLHVSEKDPVGTFTEVLK-NPFGLEDALTEMEKVIKNLIDKSKYDLALQSLQSLRL---HSIL 640

Human   744 FSEEQRFNNFLKALQEKV-------EIKQLNHF----WEIVVQDGIT 779
            ..|.:|||.:|..|::.|       |.:.:|..    .:|::.|.:|
pombe   641 EDEVERFNEYLTRLKKDVMQNNKPKENELINKIRSSGLDIILHDELT 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XRCC5	XP_054199770.1	Ku_N	104..339	CDD:427470	54/248 (22%)
		KU80	339..638	CDD:238445	77/346 (22%)
		Ku_PK_bind	688..801	CDD:462604	22/103 (21%)
pku80	NP_596791.1	vWA_ku	4..218	CDD:238735	56/256 (22%)
		KU80	222..535	CDD:238445	76/329 (23%)
		Ku_PK_bind	589..685	CDD:462604	20/99 (20%)