Protein Alignment XRCC5 and Xrcc5

DIOPT Version :10

• Sequence 1: XP_054199770.1
• Gene: XRCC5 / 7520
• HGNCID: 12833
• Length: 827
• Species: Homo sapiens
• Sequence 2: XP_006495955.1
• Gene: Xrcc5 / 22596
• MGIID: 104517
• Length: 748
• Species: Mus musculus
• Alignment Length: 749
• Identity: 573/749 - (76%)
• Similarity: 641/749 - (85%)
• Gaps: 18/749 - (2%)

Human    96 MVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTDGTD 160
            |..||||||||||:|||..|.||.||.|||.||||||:|||||||||:|:||||||||:||||||
Mouse     1 MAWSGNKAAVVLCVDVGVAMGNSFPGEESPIEQAKKVMTMFVQRQVFSESKDEIALVLYGTDGTD 65

Human   161 NPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKR 225
            |.|:|.||||||||.||||||||||||||.:||||.||||||||||||.||:||.|||||||.|:
Mouse    66 NALAGKDQYQNITVCRHLMLPDFDLLEDIGNKIQPSSQQADFLDALIVCMDLIQRETIGKKFGKK 130

Human   226 HIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLK 290
            |||:||||||.||:.|||:||.:|||..|||||||||.:.|....|:|||....|....||||.|
Mouse   131 HIEVFTDLSSPFSQDQLDVIICNLKKSGISLQFFLPFPIDKNGEPGERGDLDSGLDHLKPSFPQK 195

Human   291 GITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIERHSIHWPCRLTIGSNLSIR 355
            |:|||||||:.:|..||:|||||||||||||||||||:|||||||||.|:.|||:||||.||||:
Mouse   196 GLTEQQKEGIRMVTRVMLSLEGEDGLDEIYSFSESLRQLCVFKKIERRSMPWPCQLTIGPNLSIK 260

Human   356 IAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDIVPFSK 420
            |.|||||:||:.||:|.||||:|||||||||||||||||||||||.|||.|||:||||||:||||
Mouse   261 IVAYKSIVQEKFKKSWVVVDARTLKKEDIQKETVYCLNDDDETEVSKEDTIQGYRYGSDIIPFSK 325

Human   421 VDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEAAAVALSSLIHALDDLDMV 485
            ||||||||||||||||||||||||||.||||||:||||||||:||||||||||||:||||:|:||
Mouse   326 VDEEQMKYKSEGKCFSVLGFCKSSQVHRRFFMGHQVLKVFAAKDDEAAAVALSSLVHALDELNMV 390

Human   486 AIVRYAYDKRANPQVGVAFPHIKHNYECLVYVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVD 550
            ||||||||||:|||||||||:||..|||||||||||||||||||||||||:||..||||||:|:|
Mouse   391 AIVRYAYDKRSNPQVGVAFPYIKDAYECLVYVQLPFMEDLRQYMFSSLKNNKKCTPTEAQLSAID 455

Human   551 ALIDSMSLAKKDEKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPA 615
            .|||||||.||:|:.|.:||||||:|||||.||||:|||||||||.:|.||||||||.|||:||.
Mouse   456 DLIDSMSLVKKNEEEDIVEDLFPTSKIPNPEFQRLYQCLLHRALHLQERLPPIQQHILNMLDPPT 520

Human   616 EVTTKSQIPLSKIKTLFPLIEA-KKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEG 679
            |:..|.:.||||:||||||.|. |||:|||||::||||||:||.|||.|||:...|.|:||||||
Mouse   521 EMKAKCESPLSKVKTLFPLTEVIKKKNQVTAQDVFQDNHEEGPAAKKYKTEKEEDHISISSLAEG 585

Human   680 SVTSVGSVNPAENFRVLVKQKKASFEE----------------ASNQLINHIEQFLDTNETPYFM 728
            ::|.||||||.||||.||:||.|||||                .|.|||:|||||||||||.|||
Mouse   586 NITKVGSVNPVENFRFLVRQKIASFEEDCKPKAKNTLTQEEVATSLQLISHIEQFLDTNETLYFM 650

Human   729 KSIDCIRAFREEAIKFSEEQRFNNFLKALQEKVEIKQLNHFWEIVVQDGITLITKEEASGSSVTA 793
            ||:|||:|||||||:||||||||:||:||:|||||||||||||||||||:|||||:|..|||:||
Mouse   651 KSMDCIKAFREEAIQFSEEQRFNSFLEALREKVEIKQLNHFWEIVVQDGVTLITKDEGPGSSITA 715

Human   794 EEAKKFLAPKDKPSGDTAAVFEEGGDVDDLLDMI 827
            |||.||||||||...||... ||.||||||||||
Mouse   716 EEATKFLAPKDKAKEDTTGP-EEAGDVDDLLDMI 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XRCC5	XP_054199770.1	Ku_N	104..339	CDD:427470	177/234 (76%)
		KU80	339..638	CDD:238445	243/299 (81%)
		Ku_PK_bind	688..801	CDD:462604	92/128 (72%)
Xrcc5	XP_006495955.1	Ku_N	9..244	CDD:427470	177/234 (76%)
		KU80	244..542	CDD:238445	242/297 (81%)
		Ku_PK_bind	594..723	CDD:462604	92/128 (72%)