DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment XPO1 and emb

DIOPT Version :9

Sequence 1:NP_003391.1 Gene:XPO1 / 7514 HGNCID:12825 Length:1071 Species:Homo sapiens
Sequence 2:NP_001303316.1 Gene:emb / 34167 FlyBaseID:FBgn0020497 Length:1063 Species:Drosophila melanogaster


Alignment Length:1067 Identity:756/1067 - (70%)
Similarity:885/1067 - (82%) Gaps:8/1067 - (0%)


- Green bases have known domain annotations that are detailed below.


Human     6 TMLADHAARQLLDFSQKLDINLLDNVVNCLYHGEGAQQRMAQEVLTHLKEHPDAWTRVDTILEFS 70
            |||....|.:||||||||||||||.:|..:|..:|.|.|:||.:||.|||||:||||||:|||:|
  Fly     3 TMLTSDEAGKLLDFSQKLDINLLDKIVEVVYTAQGEQLRLAQSILTTLKEHPEAWTRVDSILEYS 67

Human    71 QNMNTKYYGLQILENVIKTRWKILPRNQCEGIKKYVVGLIIKTSSDPTCVEKEKVYIGKLNMILV 135
            ||..||:|.|||||.|||||||:||||||||||||||.|||||||||..:|:.|||:.|||||||
  Fly    68 QNQRTKFYALQILEEVIKTRWKVLPRNQCEGIKKYVVSLIIKTSSDPIVMEQNKVYLNKLNMILV 132

Human   136 QILKQEWPKHWPTFISDIVGASRTSESLCQNNMVILKLLSEEVFDFSSGQITQVKSKHLKDSMCN 200
            .|||:|||::|.||||||||||:|:||||.|||||||.|||||||||.|||||.|:|||||:||:
  Fly   133 HILKREWPRNWETFISDIVGASKTNESLCMNNMVILKNLSEEVFDFSQGQITQTKAKHLKDTMCS 197

Human   201 EFSQIFQLCQFVMENSQNAPLVHATLETLLRFLNWIPLGYIFETKLISTLIYKFLNVPMFRNVSL 265
            ||||||.||.||:|||.||.|:|.||||||||||||||||||||:.|.|||:|||:|||||||:|
  Fly   198 EFSQIFTLCSFVLENSMNAALIHVTLETLLRFLNWIPLGYIFETQQIETLIFKFLSVPMFRNVTL 262

Human   266 KCLTEIAGVSVSQYEEQFVTLFTLTMMQLKQMLPLNTNIRLAYSNGKDDEQNFIQNLSLFLCTFL 330
            |||:||||::.:.|:|.|.|||..||:||:|::..|.|:...:.:|.|.||..:.||::||||||
  Fly   263 KCLSEIAGLTAANYDENFATLFKDTMVQLEQIVGQNMNMNHVFKHGSDTEQELVLNLAMFLCTFL 327

Human   331 KEHDQLIEKRLNLRETLMEALHYMLLVSEVEETEIFKICLEYWNHLAAELYRESPFSTSASPLLS 395
            |||.:|:|....: :.|.:||.|::::||||:.|:|||||||||.|..:||....|    .|.|.
  Fly   328 KEHGKLVEDAKYV-DYLNQALMYLVMISEVEDVEVFKICLEYWNSLVEDLYNSEFF----HPTLE 387

Human   396 GSQHFDVPPRRQLYLPMLFKVRLLMVSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRET 460
            .::...|.|||:.|.|:|.|||.:|:||||||||||||||:.|||||||||||:|||||||||||
  Fly   388 STKRQQVYPRRRFYAPILSKVRFIMISRMAKPEEVLVVENENGEVVREFMKDTNSINLYKNMRET 452

Human   461 LVYLTHLDYVDTERIMTEKLHNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLL 525
            ||:|||||.|||:||||.||.|||||:|:||||||||||||||||||..||||||||||||||||
  Fly   453 LVFLTHLDSVDTDRIMTLKLLNQVNGSEFSWKNLNTLCWAIGSISGAFCEEDEKRFLVTVIKDLL 517

Human   526 GLCEQKRGKDNKAIIASNIMYIVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIK 590
            ||||||:||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||
  Fly   518 GLCEQKKGKDNKAIIASNIMYVVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIK 582

Human   591 IAQKCRRHFVQVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQTVQEHLIE 655
            ||.||||:||.:|..|...||||||..:::|||||||||||||||||||||.||.||..|:.|||
  Fly   583 IAIKCRRYFVTIQPNEACTFIDEILTTMSSIICDLQPQQVHTFYEAVGYMISAQVDQVQQDVLIE 647

Human   656 KYMLLPNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPFVIQLGRIYLDMLNV 720
            :||.|||||||.||.:|:||||.||:...||||||||||||.||||:||.:||||||||||||||
  Fly   648 RYMQLPNQVWDDIISRASKNVDFLKNMTAVKQLGSILKTNVAACKALGHAYVIQLGRIYLDMLNV 712

Human   721 YKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVL 785
            ||..||||..||:.||..|..||||::|..||:|||.|||.|||||||.|:|.:||:||||||:|
  Fly   713 YKITSENIIQAIEVNGVNVNNQPLIKTMHVVKKETLNLISEWVSRSNDNQLVMDNFIPPLLDAIL 777

Human   786 IDYQR-NVPAAREPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFF 849
            :|||| .||:||||:|||.|||||:||..|||.|:|:||||||||||:||||:||::|:||.:|:
  Fly   778 LDYQRCKVPSAREPKVLSAMAIIVHKLRQHITNEVPKIFDAVFECTLDMINKNFEDFPQHRLSFY 842

Human   850 LLLQAVNSHCFPAFLAIPPTQFKLVLDSIIWAFKHTMRNVADTGLQILFTLLQNVAQEEAAAQSF 914
            .||||||:|||.|||.|||.|||||.||::||||||||||||.||.|||.:|||:.|...|||||
  Fly   843 ELLQAVNAHCFKAFLNIPPAQFKLVFDSVVWAFKHTMRNVADMGLNILFKMLQNLDQHPGAAQSF 907

Human   915 YQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVEEGKISTSLNPGNPVNNQIFLQEYVA 979
            |||||.|||..||||||||||||||..||.||||||:|||..||:.:|.|  ..:|.||:|||||
  Fly   908 YQTYFTDILMQIFSVVTDTSHTAGLPNHAIILAYMFSLVENRKITVNLGP--IPDNMIFIQEYVA 970

Human   980 NLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLVQIKEFAGEDTSDLFLEEREIALRQ 1044
            :||||||.||.|.|||:||||||:|::::.||||||||||:||:|..|||.|||:|||||.||.:
  Fly   971 SLLKSAFTHLSDNQVKVFVTGLFNLDENVQAFKEHLRDFLIQIREATGEDDSDLYLEEREAALAE 1035

Human  1045 ADEEKHKRQMSVPGIFNPHEIPEEMCD 1071
            ....||:.|.::||:.||||:||:|.|
  Fly  1036 EQSNKHQMQRNIPGMLNPHELPEDMQD 1062

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
XPO1NP_003391.1 Necessary for HTLV-1 Rex-mediated mRNA export 1..679 484/672 (72%)
CRM1 15..1044 CDD:227432 739/1029 (72%)
Interaction with Ran and nuclear export complex formation 327..450 69/122 (57%)
Interaction with RANBP3 411..481 57/69 (83%)
Necessary for HTLV-1 Rex multimerization 411..414 1/2 (50%)
HEAT 7 775..813 29/38 (76%)
Interaction with HIV-1 Rev 800..820 14/19 (74%)
HEAT 8 885..916 21/30 (70%)
HEAT 9 917..954 29/36 (81%)
HEAT 10 1002..1039 24/36 (67%)
embNP_001303316.1 CRM1 13..1023 CDD:227432 729/1016 (72%)
IBN_N 43..109 CDD:197981 52/65 (80%)
Xpo1 120..265 CDD:285575 114/144 (79%)
CRM1_C 701..1015 CDD:285920 223/315 (71%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165145452
Domainoid 1 1.000 446 1.000 Domainoid score I528
eggNOG 1 0.900 - - E1_COG5101
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2554
Inparanoid 1 1.050 1510 1.000 Inparanoid score I100
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53807
OrthoDB 1 1.010 - - D132850at2759
OrthoFinder 1 1.000 - - FOG0003578
OrthoInspector 1 1.000 - - oto91089
orthoMCL 1 0.900 - - OOG6_101697
Panther 1 1.100 - - LDO PTHR11223
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R13754
SonicParanoid 1 1.000 - - X2450
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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