Protein Alignment XPNPEP1 and Dip-C

DIOPT Version :10

• Sequence 1: NP_001311062.1
• Gene: XPNPEP1 / 7511
• HGNCID: 12822
• Length: 695
• Species: Homo sapiens
• Sequence 2: NP_650192.1
• Gene: Dip-C / 47769
• FlyBaseID: FBgn0000455
• Length: 491
• Species: Drosophila melanogaster
• Alignment Length: 600
• Identity: 132/600 - (22%)
• Similarity: 200/600 - (33%)
• Gaps: 228/600 - (38%)

Human   103 AGTAIITEEHAAMWTDGRYFLQAAKQMDSNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVDPLII 167
            ||.||:.|           .|...|..|.|                  :.||.||   |.|..:.
  Fly    24 AGKAILKE-----------LLPGLKFNDGN------------------LLVLLEG---GKDQSLY 56

Human   168 PTDYWKKMAKVLRSAGH--HLIPVKENLVDKIWTDRPERP-CKPLLTLGLDYTGISWKDKVADLR 229
            .||    :..|.|...:  :|..|||             | |..:||:.:. ||
  Fly    57 NTD----VDYVFRQESYFQYLFGVKE-------------PGCYGILTIDVK-TG----------- 92

Human   230 LKMAERNVMWFVVTALDEI-AWLFNLRG-----SDVEHNPVFFSYAIIGLETIMLFIDGDRIDAP 288
               |:::|: ||....||. .|:..|.|     :..|.:.||:      ::.:.::::|
  Fly    93 ---AQKSVL-FVPRFPDEYGTWMGELLGLQEFKAMYEVDEVFY------VDEMSVYLEG------ 141

Human   289 SVKEHLLLDL-GLEAEYRIQVHPYKSILSELKALCADLSPREKVWVSDKASYAVSETIPKDHRCC 352
             ....|:|.| |..::..:.:.|            .|.:.:|| :|:|               |.
  Fly   142 -ASPKLILTLSGTNSDSGLTLQP------------PDFAGKEK-YVTD---------------CN 177

Human   353 MPYTPICIAKAVKNSAESEGMR-------RAHIK------------DAVALCELFNWLEKEVPKG 398
            :.|..:...:.:|:..|.|.:|       .||||            :..:|     :|......|
  Fly   178 LLYPILSECRVIKSPEEIEVLRYVAKVSSDAHIKVMRFMRPGRMEFEGESL-----FLHHAYSVG 237

Human   399 GVTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETN-RTLSLDEVYLIDSGAQ 462
            |...                   .|:..|..:|.|.:|:||......| :.:...::.|.|.||.
  Fly   238 GCRH-------------------ASYTCICGSGTNSSILHYGHAGAPNSKPVQDGDLCLFDMGAN 283

Human   463 YKDGTTDVTRTMHF-GTPTAYEKECFTYVLKGHIAVSAA-----------------VFPTGTKGH 509
            |.....|:|.|... |..|..:|..:..||....||:.:                 :.....:|.
  Fly   284 YCGYAADITCTFPANGKFTDDQKFIYNAVLDARNAVTESARDGVSWVDMHKLAGRVLLQRLKEGG 348

Human   510 LLDSFARSAL--WDSGLDYLHGTGHGVGSFLNVHE--GPCGISYKTFSDEP----------LEAG 560
            :|.......|  ..||:...||.||.:|  |:||:  |......|..| ||          |:||
  Fly   349 MLKGDVEEMLEAGVSGVFQPHGLGHLIG--LDVHDVGGYLPKEPKRPS-EPWLSKLRFARILKAG 410

Human   561 MIVTDEPGYY-----EDGAF---------------------GIRIENVVLVVPVKTKYNFNNRGS 599
            |.||.|||.|     .|.|.                     |:|||:.||:    ||....|
  Fly   411 MYVTIEPGCYFINWLMDRALADPNIAKFINAEMFNRFRNFGGVRIEDDVLI----TKTGVEN--- 468

Human   600 LTFEPLTLVPIQTKM 614
            ....|.|:..|:..|
  Fly   469 FAIVPRTVEDIEATM 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XPNPEP1	NP_001311062.1	Creatinase_N	53..197	CDD:480631	23/95 (24%)
		Creatinase_N_2	200..369	CDD:465053	32/176 (18%)
		APP	372..594	CDD:238518	70/299 (23%)
		Peptidase_M24_C	600..>627	CDD:465052	3/14 (21%)
Dip-C	NP_650192.1	AMP_N	12..158	CDD:198079	46/211 (22%)
		Prolidase	195..468	CDD:238520	71/303 (23%)