Protein Alignment XPNPEP1 and CG6225

DIOPT Version :10

• Sequence 1: NP_001311062.1
• Gene: XPNPEP1 / 7511
• HGNCID: 12822
• Length: 695
• Species: Homo sapiens
• Sequence 2: NP_650221.1
• Gene: CG6225 / 41559
• FlyBaseID: FBgn0038072
• Length: 704
• Species: Drosophila melanogaster
• Alignment Length: 739
• Identity: 218/739 - (29%)
• Similarity: 335/739 - (45%)
• Gaps: 118/739 - (15%)

Human     3 ASRKPPRVRVNHQDF-QLRNLRIIEPNEVTHSGDTGVETDGRMPPKVTSELLRQLRQAMRNSEYV 66
            |:.||...   |::. |.|..:.|:|..|.|:                  .|..:|:.|:....:
  Fly    22 AAEKPTGY---HREICQYRKGKHIQPMSVYHN------------------RLMAMREQMQIRATL 65

Human    67 TEP-IQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSAGTAIITEEHAAMWTDGRYFLQAAKQMD 130
            ..| |..||:||.|.|.::.:|..|.|..::|||.|....|.:|...||:|.:.||..||..:::
  Fly    66 QGPEIYGYILPSTDEHLNQEVAARDQRLRYLSGFSGVRAFAAVTSHGAAIWVENRYAQQADGELE 130

Human   131 SNWTL-MKMGLKDTPTQEDWLVSVLPEGSRVGVDPLIIPTDYWKKMAKVLRSAGHHLIPVKENLV 194
            .:|.: :..|   ..:..|||.|.:....|||.||.::|...|.:..:.|......|:.:..|||
  Fly   131 CDWEIYLTSG---NVSVADWLGSHVHIDKRVGADPHLVPHSLWVQWERELEDKFLKLVRINTNLV 192

Human   195 DKIWTD-RPERPCKPLLTL-GLDYTGISWKDKVADLRLKMAERNVMWFVVTALDEIAWLFNLRGS 257
            |.||.| |||.|...::.: ...:.|.||:|||.:||.::|.......|||:|.|||:|.|:||:
  Fly   193 DHIWGDERPEMPKNQVIKVHEKHFAGESWQDKVKELRRRLAHLGCDAMVVTSLTEIAYLLNIRGT 257

Human   258 DVEHNPVFFSYAIIGLETIMLFIDGDRIDAPSVKEHLLLDLGLEAEYR--------IQVHPYKSI 314
            |:.:.||..|||:|..:.|..::|           |..:.||::...|        :::..|..|
  Fly   258 DIPYTPVIKSYAVISRDDIFFYVD-----------HSKISLGIDLHLRTDCFNEDCVKIKEYNQI 311

Human   315 LSELK------------ALCA-DLSPREKVWVSDKASYAVSETIPKDHRCCMPYTPICIAKAVKN 366
            .|:::            |.|. ||...|.::.|......|.|           .:||...:|.||
  Fly   312 WSDIRTYAQIWKRVLVPAPCVQDLGASEAIYTSMPGKIVVWE-----------ISPIIFMRAQKN 365

Human   367 SAESEGMRRAHIKDAVALCELFNWLEKEVPKGGVTEISAADKAEEFRRQQADFVDLSFPTISSTG 431
            |.|..|||||||:|..|:||..:.:|........||.....:.|.:|..|.....||..|:.:.|
  Fly   366 SDEQAGMRRAHIRDGAAICEAMSNMETRFHTEQWTEEKIKYEVELWRLSQKHAKGLSLRTVVAYG 430

Human   432 PNGAIIHYAPVPETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIA 496
            .:.|:.:|.....||..:|...:.:|:||.||.:|||||:||..||.||...|:.:|.||.|.:.
  Fly   431 EHSALPYYISSNVTNIEVSDQSLLVIESGGQYLEGTTDVSRTFIFGEPTHEMKKAYTNVLAGILH 495

Human   497 VSAAVFPTGTKGHLLDSFARSALWDSGLDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGM 561
            ::...||:..|...:|:..||.:|....|:...||||:|||.:|.|.|..:||...|....:.|.
  Fly   496 LAQLKFPSDLKPSEVDALVRSMVWKDMTDFPQATGHGIGSFGSVEEPPISVSYGKNSSFHFKQGY 560

Human   562 IVTDEPGYYEDGAFGIRIENVVLVVPVKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDSLTDKEE- 625
            ..:.|.|||:...||:|::||:.||.....:....| .|.|..:|:||.:.|:||...|:..|:
  Fly   561 FFSSESGYYKRDDFGVRLKNVLEVVDTGHTHPSGAR-FLAFRDVTMVPYEPKLIDSTLLSAAEKR 624

Human   626 -------------------LWNGILPARSLFCLFQFTVRLAQQLPPDLQGCDWEGIAETGPPGSS 671
                               |.|    .|:.:.:...|..:.:.||.|
  Fly   625 LLNEYNAKIRNDIGDELKRLGN----MRAFYWMMNQTRHIREYLPED------------------ 667

Human   672 RVAHQRDATHLQTALINTSPVLFL 695
               ..|.||...:...:.||::.|
  Fly   668 ---EYRSATGAGSCGHSASPLILL 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XPNPEP1	NP_001311062.1	Creatinase_N	53..197	CDD:480631	46/145 (32%)
		Creatinase_N_2	200..369	CDD:465053	55/191 (29%)
		APP	372..594	CDD:238518	80/221 (36%)
		Peptidase_M24_C	600..>627	CDD:465052	10/46 (22%)
CG6225	NP_650221.1	Creatinase_N	89..195	CDD:480631	34/108 (31%)
		Creatinase_N_2	199..368	CDD:465053	54/190 (28%)
		APP	371..594	CDD:238518	80/222 (36%)
		Peptidase_M24_C	597..660	CDD:465052	14/66 (21%)