Protein Alignment XPNPEP1 and ApepP

DIOPT Version :10

• Sequence 1: NP_001311062.1
• Gene: XPNPEP1 / 7511
• HGNCID: 12822
• Length: 695
• Species: Homo sapiens
• Sequence 2: NP_477409.1
• Gene: ApepP / 35029
• FlyBaseID: FBgn0026150
• Length: 613
• Species: Drosophila melanogaster
• Alignment Length: 601
• Identity: 290/601 - (48%)
• Similarity: 401/601 - (66%)
• Gaps: 24/601 - (3%)

Human    49 TSELLRQLRQAMRNSEYVTE-PIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSAGTAIITEEH 112
            |:::|.:||:.|..::.... .|.|||:||.|||||||....|.||:||||||||||||:||.|.
  Fly     5 TTQILTRLRELMLRAQVGDSCGISAYIVPSDDAHQSEYQCQHDERRSFVSGFDGSAGTAVITTET 69

Human   113 AAMWTDGRYFLQAAKQMDSNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVDPLIIPTDYWKKMAK 177
            |.:||||||:.||.||:||||.||:.||..||:...||...||:||.|||||.::....||.:..
  Fly    70 ALLWTDGRYYQQAEKQLDSNWVLMRDGLSATPSIGAWLAKNLPKGSFVGVDPRLLSFRVWKPIET 134

Human   178 VLRSAGHHLIPVKENLVDKIW-TDRPERPCKPLLTLGLDYTGISWKDKVADLRLKMAERNVMWFV 241
            .|.||...|:|::.||:|::| .|:|.:....::||.|:::|::...|...:|.::.|:|....|
  Fly   135 ELSSAECQLVPIEGNLIDEVWGEDQPPQTSNKIITLKLEHSGVTIAKKWDVVRQQLKEKNADALV 199

Human   242 VTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLFIDGDRIDAPSVKEHLLLDLGLEAEYRI 306
            |:|||||||..||||||::.|||||||.|:..:.::||:|..::....|:..      .|...:|
  Fly   200 VSALDEIAWFLNLRGSDIDFNPVFFSYLIVTNDELLLFVDSGKLPTDFVQHQ------KENNVQI 258

Human   307 QVHPYKSILSELKALCADLSPRE-KVWVSDKASYAVSETIPKDHRCCMPYTPICIAKAVKNSAES 370
            .|.||.||..|:..:   :|.|| |:|::..:||.::..|||..| ....||||:.||:||..|.
  Fly   259 SVLPYASIGIEISKI---VSTRESKIWIAPTSSYYLTALIPKSRR-IQEVTPICVLKAIKNDVEI 319

Human   371 EGMRRAHIKDAVALCELFNWLEKEVPKGG-VTEISAADKAEEFRRQQADFVDLSFPTISSTGPNG 434
            .|...:||:|.||||:.|.|||.:|.||. |.|:|.|||.|.||..:..::.|||.|||::||||
  Fly   320 AGFINSHIRDGVALCQYFAWLEDQVNKGAEVDEMSGADKLESFRSTKDKYMGLSFTTISASGPNG 384

Human   435 AIIHYAPVPETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSA 499
            ::|||.|..||||.::..|:||.||||||.|||||||||:|||.||.::||.:|.||||.::..:
  Fly   385 SVIHYHPKKETNRKINDKEIYLCDSGAQYLDGTTDVTRTLHFGEPTEFQKEAYTRVLKGQLSFGS 449

Human   500 AVFPTGTKGHLLDSFARSALWDSGLDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEP-LEAGMIV 563
            .|||...||.:||:.||.||||.||||.||||||||.||||||||.|:..:...|:| |:|.|.:
  Fly   450 TVFPAKVKGQVLDTLARKALWDVGLDYGHGTGHGVGHFLNVHEGPMGVGIRLMPDDPGLQANMFI 514

Human   564 TDEPGYYEDGAFGIRIENVVLVVPVKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDSLTDKE---- 624
            ::|||:|:||.||||:|::|.:||.:..:||:|||:|||:.:|:.|.|||||..:.|:|.|
  Fly   515 SNEPGFYQDGEFGIRVEDIVQIVPGQVAHNFSNRGALTFKTITMCPKQTKMIKKELLSDAEVKLL 579

Human   625 -----ELWNGILPARS 635
                 ::|:.:.|..|
  Fly   580 NSYHQQVWDTLSPILS 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XPNPEP1	NP_001311062.1	Creatinase_N	53..197	CDD:480631	77/144 (53%)
		Creatinase_N_2	200..369	CDD:465053	64/169 (38%)
		APP	372..594	CDD:238518	125/223 (56%)
		Peptidase_M24_C	600..>627	CDD:465052	13/35 (37%)
ApepP	NP_477409.1	Creatinase_N	9..154	CDD:460159	77/144 (53%)
		Creatinase_N_2	158..318	CDD:465053	64/169 (38%)
		APP	321..545	CDD:238518	125/223 (56%)
		Peptidase_M24_C	551..613	CDD:465052	16/45 (36%)