Protein Alignment XPNPEP1 and CG9581

DIOPT Version :10

• Sequence 1: NP_001311062.1
• Gene: XPNPEP1 / 7511
• HGNCID: 12822
• Length: 695
• Species: Homo sapiens
• Sequence 2: NP_608376.1
• Gene: CG9581 / 33017
• FlyBaseID: FBgn0031093
• Length: 545
• Species: Drosophila melanogaster
• Alignment Length: 512
• Identity: 116/512 - (22%)
• Similarity: 194/512 - (37%)
• Gaps: 162/512 - (31%)

Human   175 MAKVLR----------SAGH-HLIPVKENLVDKIWTDRPERPCKPLLTL-------GLDYTGISW 221
            :|::||          |..| |||...|.:.....|:..||..:.:..:       |.::.|.|
  Fly    56 VAQILRQQKGNLGQPTSVSHPHLIQPDELVPGVELTEIKERRSQLMQNIRAYARSFGGEFNGHS- 119

Human   222 KDKVADLRLKMAERNVMWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLE---TIMLFIDGD 283
             .....|.|..|.:..|      ..:|.::|. :.||       |.|....||   .::|.||
  Fly   120 -SSCHMLVLGAASKKYM------SGKIPYVFR-QNSD-------FYYLTGCLEPDAVLLLTID-- 167

Human   284 RIDAPSVKEHLLL-----------------DLGLEAEYRIQVHPYKSILSELKALCAD----LSP 327
              :|.:|:..|.:                 :|.:......:.||    ||:|:|:.|.    |.|
  Fly   168 --EAQNVQSELFMRPKDPHAELWDGPRTGPELAVPLFGVTEAHP----LSQLEAVLAKRAGALKP 226

Human   328 REKVWVSDKAS--YAVSETIPK----DHRCCMP-YTPICIAKAVKNSAESEGMRRAHIKDAVALC 385
            .  :|...|::  .:::|.:.:    ..|..:| ||.:...:.:|:..|.:.|||.        |
  Fly   227 H--IWFDQKSTDLPSLAENMLRLSGNQQRPLLPAYTFLEAMRLLKSRDEMQLMRRT--------C 281

Human   386 EL----FNWLEKEVPKGGVTE---ISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVP 443
            ::    ||.:..|. :.|.:|   .:|.|  .:.|.:.|.:  |::|.:.:.|.|..:|||.
  Fly   282 DIASRSFNEVMAET-RPGQSEHHLFAAID--YKCRMRNASY--LAYPPVVAAGKNATVIHYV--- 338

Human   444 ETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMH----FGTP--TAY------EKECFTYVLKGHIA 496
            ..::.|...::.|:|:|.:|...|:|:|||..    |..|  |.|      ::|....|:|
  Fly   339 ANSQLLGQQDLVLMDAGCEYGGYTSDITRTWPASGVFTEPQRTLYDMLHQLQEEIIGNVMK---- 399

Human   497 VSAAVFPTGTKGHLLDSFARSALWDSGLDYLHGTG---------------------HGVGSFL-- 538
                     ..|..||....:..:..| .||...|                     |.|..:|
  Fly   400 ---------PGGETLDQLFETTCYKLG-KYLQEIGLVGKSFSEYKELVSQGYRFCPHHVSHYLGM 454

Human   539 NVHEGPCGISYKTFSDEPLEAGMIVTDEPGYY----------EDGAFGIRIENVVLV 585
            :||:.|     ....:..:..||:.|.|||.|          |....|||||:.:|:
  Fly   455 DVHDTP-----HVPRNTRIVPGMVFTVEPGIYIGQDCGDVPPEFRGIGIRIEDDLLI 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XPNPEP1	NP_001311062.1	Creatinase_N	53..197	CDD:480631	9/32 (28%)
		Creatinase_N_2	200..369	CDD:465053	41/206 (20%)
		APP	372..594	CDD:238518	64/266 (24%)
		Peptidase_M24_C	600..>627	CDD:465052
CG9581	NP_608376.1	AMP_N	94..229	CDD:461581	33/160 (21%)
		Prolidase	274..517	CDD:238520	64/268 (24%)