Protein Alignment XDH and xdh

DIOPT Version :10

• Sequence 1: NP_000370.2
• Gene: XDH / 7498
• HGNCID: 12805
• Length: 1333
• Species: Homo sapiens
• Sequence 2: XP_688983.3
• Gene: xdh / 560486
• ZFINID: ZDB-GENE-070719-9
• Length: 1351
• Species: Danio rerio
• Alignment Length: 1344
• Identity: 916/1344 - (68%)
• Similarity: 1095/1344 - (81%)
• Gaps: 23/1344 - (1%)

Human     4 DKLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKIVHF 68
            |.|||||||:|:.|||||||.|||.||||.|||:||||||.||||||||||:|||...||:|:|:
Zfish    17 DDLVFFVNGKKITEKNADPEITLLTYLRRSLGLTGTKLGCAEGGCGACTVMVSKYHPNQNRIIHY 81

Human    69 SANACLAPICSLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPE 133
            :.||||||:|||||.||||||||||..::||||||||||:|||||||||||||||||.||||.|:
Zfish    82 AINACLAPLCSLHHCAVTTVEGIGSVASKLHPVQERIAKAHGSQCGFCTPGIVMSMYALLRNNPQ 146

Human   134 PTMEEIENAFQGNLCRCTGYRPILQGFRTFARDGGCCGGDGNNPNCCM--NQKKDHSVSLSP--S 194
            |||.:|:.||||||||||||||||:|:|||.:|||||||......|||  ...::|..|..|  .
Zfish   147 PTMHDIQEAFQGNLCRCTGYRPILEGYRTFTKDGGCCGGKSQTNGCCMTNGNTQEHENSAHPVQH 211

Human   195 LFKPEEFTPLDPTQEPIFPPELLRLKDTPRKQLRFEGERVTWIQASTLKELLDLKAQHPDAKLVV 259
            |:...||.|||||||.||||||:.|....::::||.||||.|||..:|||||:|||.:|:|||||
Zfish   212 LYDQSEFMPLDPTQEIIFPPELVSLSKQTQREMRFVGERVLWIQPCSLKELLELKATYPNAKLVV 276

Human   260 GNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLSIVEKTLVDAVAKLPAQKT 324
            ||||:||||||||:|:|:|:.||:|||||.::|..|||..||:..|:::...|..||.||||.:|
Zfish   277 GNTEVGIEMKFKNLLYPVILAPAYIPELNIIQHTQDGIEVGASVTLTVLGDVLQSAVKKLPAYQT 341

Human   325 EVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVSRGTRRTVQMDHTF 389
            |||:.||||||||||:|:::||:|||||:||||||||||||||:|.|||::|:|.:|.::||..|
Zfish   342 EVFKAVLEQLRWFAGQQIRNVAAVGGNIMTASPISDLNPVFMAAGCKLTVMSKGEKRVLEMDDKF 406

Human   390 FPGYRKTLLSPEEILLSIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTTEVQELAL 454
            |.|||||.|.||||||||||||:::|:|||||||:.|:||||:.||.||.|.||..:..||.:.:
Zfish   407 FTGYRKTALKPEEILLSIEIPYTKKGQYFSAFKQSPRKEDDISIVTCGMNVYFKEQSNTVQSIRI 471

Human   455 CYGGMANRTISALKTTQRQLSKLWKEELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTLSFFFKF 519
            .|||||..|:.|..|..:.|::.|.|:||::.|:.||||:.|.|.||||||.:|.|||:|.|:||
Zfish   472 SYGGMAPVTVLATATCNKLLNRQWNEDLLEEACSSLAEEMSLSPSAPGGMVTYRRTLTISLFYKF 536

Human   520 YLTVLQKLGQE------NLEDKCGKLDPTFASATLLFQKDPPADVQLFQEVPKGQSEEDMVGRPL 578
            :|||..||...      .:||    :.|.|::||.|||.|.|:.|||:||||.||:|:|:||.|:
Zfish   537 FLTVQHKLAVSLQMEGVTVED----IQPEFSTATELFQVDTPSSVQLYQEVPPGQNEDDVVGHPI 597

Human   579 PHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPG 643
            .||:|..||:||||||||:|.|||||.|.|||||:|||.|||||||.|..|||.|.||||.|:||
Zfish   598 IHLSALKQATGEAVYCDDMPCYENELHLALVTSTKAHALIKSIDTSSAMSVPGVVAFISAKDIPG 662

Human   644 SNITG-ICNDETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEEL-PAIITIEDAIKNN 706
            ||:|| :..||||||.|||||||||:||:||||..|.||||:.|||:|||| |.|:||:|||.|.
Zfish   663 SNMTGPVVYDETVFADDKVTCVGHIVGAIVADTQAHAQRAAKVVKISYEELKPVIVTIQDAINNK 727

Human   707 SFYGPELKIEKGDLKKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTM 771
            ||:.|...|||||:.:||.::|:::.||::|||||.|||||:||:|||:||.||||||||||:..
Zfish   728 SFFEPVRTIEKGDVAQGFKDSDHILHGEMHIGGQEQFYLETNCTLAVPRGEDGEMELFVSTQSAS 792

Human   772 KTQSFVAKMLGVPANRIVVRVKRMGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLI 836
            |||:.|||.|||||||:|.|||||||||||||:|||::||.||:||.|...|||||||||||||:
Zfish   793 KTQALVAKALGVPANRVVCRVKRMGGGFGGKESRSTILSTVVAVAAQKVKCPVRCMLDRDEDMLV 857

Human   837 TGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDNCYKIPNIRGTGRL 901
            |||||||..:|||||||.|.|:||||..:||.||:.|||.||:|||||||||.|.||||.|||.:
Zfish   858 TGGRHPFFGQYKVGFMKNGRVMALEVTLYSNAGNSLDLSLSILERALFHMDNSYNIPNICGTGYM 922

Human   902 CKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLTHFNQKLEGFTLP 966
            ||||||||:|||||||||||:|||.|||:||::||:|||||||.|:|.|||||||||:|:.||:.
Zfish   923 CKTNLPSNSAFRGFGGPQGMMIAESWMSDVALSCGLPAEEVRRMNMYNEGDLTHFNQRLDQFTIA 987

Human   967 RCWEECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSVL 1031
            ||||||:..|.::.||..|:|:|:::.|.||||.|||||||||||..||||||||:|||:|||||
Zfish   988 RCWEECMQLSDFNKRKDAVEKYNRQHRWTKRGLSIIPTKFGISFTAVFLNQAGALVHVYSDGSVL 1052

Human  1032 LTHGGTEMGQGLHTKMVQVASRALKIPTSKIYISETSTNTVPNTSPTAASVSADLNGQAVYAACQ 1096
            |||||||||||||||||||||:.|:||.:||:|:||||:|||||||||||.|:||||.|||.|||
Zfish  1053 LTHGGTEMGQGLHTKMVQVASKTLEIPCTKIHITETSTSTVPNTSPTAASASSDLNGMAVYNACQ 1117

Human  1097 TILKRLEPYKKKNPSGSWEDWVTAAYMDTVSLSATGFYRTPNLGYSFETNSGNPFHYFSYGVACS 1161
            |||:||:|:|:|||.|.|||||||||.|.|:|||.|||:||:|||.|:||||.||:|||||||.|
Zfish  1118 TILQRLQPFKEKNPKGCWEDWVTAAYFDRVNLSANGFYKTPDLGYDFDTNSGRPFNYFSYGVAVS 1182

Human  1162 EVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPS 1226
            |||||||||.||||.|.||||||.|||||:|||||||.|:|||||||||||.|||:|.|:||||.
Zfish  1183 EVEIDCLTGSHKNLHTSIVMDVGKSLNPALDIGQVEGGFMQGLGLFTLEELRYSPDGYLYTRGPG 1247

Human  1227 TYKIPAFGSIPIEFRVSLLRDCPNKKAIYASKAVGEPPLFLAASIFFAIKDAIRAARAQH--TGN 1289
            .|||||||.||.|.:||||||.||.|||::||||||||||||||:|:||||||.||||:.  ||.
Zfish  1248 MYKIPAFGDIPSELKVSLLRDAPNDKAIFSSKAVGEPPLFLAASVFYAIKDAITAARAESGLTGP 1312

Human  1290 NVKELFRLDSPATPEKIRNACVDKFTTLCVTGVPENCKPWSVRV 1333
                 ||||||||||:|||||.||||.||....|....||:|:|
Zfish  1313 -----FRLDSPATPERIRNACEDKFTKLCPPADPGTFIPWAVQV 1351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XDH	NP_000370.2	PLN02906	23..1319	CDD:215491	895/1309 (68%)
xdh	XP_688983.3	PLN02906	36..1336	CDD:215491	894/1308 (68%)