Protein Alignment XDH and ry

DIOPT Version :10

• Sequence 1: NP_000370.2
• Gene: XDH / 7498
• HGNCID: 12805
• Length: 1333
• Species: Homo sapiens
• Sequence 2: NP_524337.1
• Gene: ry / 41605
• FlyBaseID: FBgn0003308
• Length: 1335
• Species: Drosophila melanogaster
• Alignment Length: 1356
• Identity: 706/1356 - (52%)
• Similarity: 931/1356 - (68%)
• Gaps: 48/1356 - (3%)

Human     1 MTADKLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKI 65
            |:...|||||||:||.|.:.|||.|||.:||.||.|.||||||.||||||||||:|:.||..|||
  Fly     1 MSNSVLVFFVNGKKVTEVSPDPECTLLTFLREKLRLCGTKLGCAEGGCGACTVMVSRLDRRANKI 65

Human    66 VHFSANACLAPICSLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRN 130
            .|.:.||||.|:||:|..|||||||||||||||||||||:||:|||||||||||||||||.||||
  Fly    66 RHLAVNACLTPVCSMHGCAVTTVEGIGSTKTRLHPVQERLAKAHGSQCGFCTPGIVMSMYALLRN 130

Human   131 QPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFARDGGCCGGDGNNPNCCMNQKK--DHSVSLSP 193
            ..:|:|.::|.||||||||||||||||:|::||.::..|    |....||....|  ........
  Fly   131 AEQPSMRDLEVAFQGNLCRCTGYRPILEGYKTFTKEFAC----GMGEKCCKVSGKGCGTDAETDD 191

Human   194 SLFKPEEFTPLDPTQEPIFPPELLRLKDT-PRKQLRFEGERVTWIQASTLKELLDLKAQHPDAKL 257
            .||:..||.||||:|||||||| |:|.|. ..:.|.|..:||||.:.:.|:|||.|||:||.|||
  Fly   192 KLFERSEFQPLDPSQEPIFPPE-LQLSDAFDSQSLIFSSDRVTWYRPTNLEELLQLKAKHPAAKL 255

Human   258 VVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLSIVEKTLVDAVAKLPAQ 322
            ||||||:|:|:|||:.|:|.::.|..:.||..::...|||.||||..|..::..|...:.:||..
  Fly   256 VVGNTEVGVEVKFKHFLYPHLINPTQVKELLEIKENQDGIYFGAAVSLMEIDALLRQRIEQLPES 320

Human   323 KTEVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVS----RGTRRTV 383
            :|.:|:..::.|.:|||||:::||.:||||:|.|||||:|||..|:||:|.:.|    :..:|:|
  Fly   321 ETRLFQCTVDMLHYFAGKQIRNVACLGGNIMTGSPISDMNPVLSAAGAQLEVASFVDGKLQKRSV 385

Human   384 QMDHTFFPGYRKTLLSPEEILLSIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTTE 448
            .|...||.|||:.::...|:||.|....:...:|..|||||.||:||||.|.:.:.|.|:..:..
  Fly   386 HMGTGFFTGYRRNVIEAHEVLLGIHFRKTTPDQYIVAFKQARRRDDDIAIVNAAINVRFEEKSNI 450

Human   449 VQELALCYGGMANRTISALKTTQRQLSKLWKEELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTL 513
            |.|:::.:||||..|:.|.:|:|..:.:.|..:|::.|...|..||.|...|||||:.:|..|.:
  Fly   451 VAEISMAFGGMAPTTVLAPRTSQLMVGQEWSHQLVERVAESLCTELPLAASAPGGMIAYRRALVV 515

Human   514 SFFFKFYLTVLQKLGQENL--------EDKCGKLDPTFASATLLFQKDPPADVQLFQEVPKGQSE 570
            |.|||.||.:..||.:..:        |::.|.  .||.:..|       ...|||:.|...|..
  Fly   516 SLFFKAYLAISLKLSKSGITSSDALPSEERSGA--ETFHTPVL-------KSAQLFERVCSDQPI 571

Human   571 EDMVGRPLPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPG---F 632
            .|.:|||..|.||..||:|||:|.|||||.:.|:.|..|.||:..|||..:|.|||..:.|   |
  Fly   572 CDPIGRPKVHAAALKQATGEAIYTDDIPRMDGEVYLAFVLSTKPRAKITKLDASEALALDGVHQF 636

Human   633 VCFISADDVPGSNITG-ICNDETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEEL-PA 695
            .|:  .|.....|..| :.:||.|||..:|.|.|.|:||:.||.....||||:.||:.|||| |.
  Fly   637 FCY--KDLTEHENEVGPVFHDEHVFAAGEVHCYGQIVGAIAADNKALAQRAARLVKVEYEELSPV 699

Human   696 IITIEDAIKNNSFYGPELK--IEKGDLKKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEA 758
            |:|||.||::.|:: |:..  :.||::::..::||:...|...:|||||||||||..:|||: ::
  Fly   700 IVTIEQAIEHKSYF-PDYPRFVTKGNVEEALAQADHTFEGTCRMGGQEHFYLETHAALAVPR-DS 762

Human   759 GEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKRMGGGFGGKETRSTVVSTAVALAAYKTGRP 823
            .|:|||.|||:..:.|..||.:..:||:|:|.|.||:||||||||:|...|:..||||||:.|||
  Fly   763 DELELFCSTQHPSEVQKLVAHVTALPAHRVVCRAKRLGGGFGGKESRGISVALPVALAAYRMGRP 827

Human   824 VRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDN 888
            |||||||||||||||.|||||.:|||||.|.|.:.|.:::.::|.|.:.|||.|::|||:||.:|
  Fly   828 VRCMLDRDEDMLITGTRHPFLFKYKVGFTKEGLITACDIECYNNAGWSMDLSFSVLERAMFHFEN 892

Human   889 CYKIPNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDL 953
            ||:|||:|..|.:||||||||||||||||||||...|..:.:||...|....:|.|.|.||.||.
  Fly   893 CYRIPNVRVGGWVCKTNLPSNTAFRGFGGPQGMYAGEHIIRDVARIVGRDVVDVMRLNFYKTGDY 957

Human   954 THFNQKLEGFTLPRCWEECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQA 1018
            ||::|:||.|.:.||.|:||..|:|..::.|:.:||:||.|:|||:.::|||:||:|.|..||||
  Fly   958 THYHQQLEHFPIERCLEDCLKQSRYDEKRQEIARFNRENRWRKRGMAVVPTKYGIAFGVMHLNQA 1022

Human  1019 GALLHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIYISETSTNTVPNTSPTAASVS 1083
            |:|:::|.||||||:|||.|:||||:|||:|.|:|||.||:..|:||||:|:.|||||||||||.
  Fly  1023 GSLINIYGDGSVLLSHGGVEIGQGLNTKMIQCAARALGIPSELIHISETATDKVPNTSPTAASVG 1087

Human  1084 ADLNGQAVYAACQTILKRLEPYKKKNPSGSWEDWVTAAYMDTVSLSATGFYRTPNLGYSFETN-S 1147
            :||||.||..||:.:.|||.|.|:..|.|:|::|:..||.|.|||||||||..|.:||..||| :
  Fly  1088 SDLNGMAVLDACEKLNKRLAPIKEALPGGTWKEWINKAYFDRVSLSATGFYAMPGIGYHPETNPN 1152

Human  1148 GNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEEL 1212
            ...:.|::.||..:.||||||||||:.|.||||||:||||||||||||:||||:||.||||||||
  Fly  1153 ARTYSYYTNGVGVTVVEIDCLTGDHQVLSTDIVMDIGSSLNPAIDIGQIEGAFMQGYGLFTLEEL 1217

Human  1213 HYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKKAIYASKAVGEPPLFLAASIFFAIKD 1277
            .|||:|.|::|||..||:|.|..||.||.||||...||.:|:|:||||||||||:.:|.|||||:
  Fly  1218 MYSPQGMLYSRGPGMYKLPGFADIPGEFNVSLLTGAPNPRAVYSSKAVGEPPLFIGSSAFFAIKE 1282

Human  1278 AIRAARAQH--TGNNVKELFRLDSPATPEKIRNACVDKFTTLCVTGVPENCKPWSV 1331
            ||.|||...  :|:     |.|::|:|..:||.||.||||.|.....|.:..||::
  Fly  1283 AIAAAREDQGLSGD-----FPLEAPSTSARIRIACQDKFTELLEIPEPGSFTPWNI 1333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XDH	NP_000370.2	PLN02906	23..1319	CDD:215491	690/1320 (52%)
ry	NP_524337.1	PLN02906	25..1317	CDD:215491	686/1314 (52%)