Protein Alignment XDH and xdh-1

DIOPT Version :10

• Sequence 1: NP_000370.2
• Gene: XDH / 7498
• HGNCID: 12805
• Length: 1333
• Species: Homo sapiens
• Sequence 2: NP_502747.1
• Gene: xdh-1 / 178381
• WormBaseID: WBGene00010083
• Length: 1358
• Species: Caenorhabditis elegans
• Alignment Length: 1376
• Identity: 647/1376 - (47%)
• Similarity: 843/1376 - (61%)
• Gaps: 75/1376 - (5%)

Human     3 ADKLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKIVH 67
            |..|||:|||::|.||:.||:.||..|||.||.|:|||:||.||||||||:|:|..:  ..:|.|
 Worm    13 ATNLVFYVNGKRVEEKDVDPKMTLATYLRDKLKLTGTKIGCNEGGCGACTIMISHIE--NGEIKH 75

Human    68 FSANACLAPICSLHHVAVTTVEGIGS-TKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQ 131
            ||||:||.|:|.:...|||||||||| .|.||||||||:||:|||||||||||.||:||.||||.
 Worm    76 FSANSCLMPVCGVFGKAVTTVEGIGSVAKNRLHPVQERLAKAHGSQCGFCTPGFVMAMYALLRNN 140

Human   132 PEPTMEEIENAFQGNLCRCTGYRPILQGFRTFARD----------GGCCGGDGNNPNCCMNQK-- 184
            |.||:.:|....||||||||||||||:.|.:||.|          .||    |...|||..:|
 Worm   141 PNPTISDINLGLQGNLCRCTGYRPILEAFYSFAVDESGTLKVTEENGC----GMGENCCKVKKTA 201

Human   185 ---------------KDHSVSLSPSLFKPEEFTPLDPTQEPIFPPELLRLKDTPRKQLRFEGERV 234
                           :...:.||..    .:..|.|||||.||||| |:|.........::....
 Worm   202 CGGSDETTPGYTGGERKRKIQLSDM----SDCKPYDPTQELIFPPE-LKLHGYESMSFAYDHHHT 261

Human   235 TWIQASTLKELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISF 299
            .|.|..:..:||.||.:.|.|:|:.||:|:.||:||:.:..|.::.|..:..|:......||:..
 Worm   262 KWYQPVSYDDLLSLKRELPHARLISGNSELAIELKFRFIDLPAVINPRQVKVLHEKHLENDGVYM 326

Human   300 GAACPLSIVEKTLVDAVAKLPAQKTEVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISDLNPV 364
            |....|:.::...|..:..||.::|.|.:.|.|.|.||||..|::||||.|||.||||||||||:
 Worm   327 GTGMSLTDMDNYSVQLMKDLPREQTAVLKHVHEMLHWFAGIHVRNVASVAGNIATASPISDLNPI 391

Human   365 FMASGAKLTLVS--RGTRRTVQMDHTFFPGYRKTLLSPEEILLSIEIPYSREGEYFSAFKQASRR 427
            :|||.|.:.|.|  ||.:| |.:|..||.|||||::..:||:.::.:|...|.|:|:|:|||.||
 Worm   392 WMASNALVVLDSEARGEKR-VHIDEKFFLGYRKTVIQQDEIIKAVIVPLLEENEHFAAYKQAQRR 455

Human   428 EDDIAKVTSGMRVLFKPGTTEVQELALCYGGMANRTISALKTTQRQLSKLWKEELLQDVCAGLAE 492
            |||||.||....|...|.|..|:::.:.|||||..|..||.|.::.:.:.|.:..|......|::
 Worm   456 EDDIAIVTGAFLVKLDPKTLVVEKIRISYGGMAPTTKLALTTMEKLIGEKWSQTFLDKALGLLSD 520

Human   493 ELHLPPDAPGGMVDFRCTLTLSFFFKFYLTVLQKLGQENL-----EDKCGKLDPTFASATLLFQK 552
            ||.||...||||..:|.:|.|||||||:|.|.:||....:     :.|.|:..|....||
 Worm   521 ELKLPAGVPGGMSQYRLSLALSFFFKFFLGVSKKLELTEIKYVDADVKIGQNVPETLYAT----- 580

Human   553 DPPADVQLFQEVPKGQSEEDMVGRPLPHLAADMQASGEAVYCDDIPRYE-NELSLRLVTSTRAHA 616
                  ||:|||...|...|.:|||:.|::.|...:|||||||||...: |.::  .|.|..||.
 Worm   581 ------QLYQEVKANQPAHDPLGRPIKHVSGDKHTTGEAVYCDDINVADCNHIA--FVLSPIAHG 637

Human   617 KIKSIDTSEAKKVPGFVCFISADDVPGSNITGICNDETVFAKDKVTCVGHIIGAVVADTPEHTQR 681
            .:.|||.:.|.::.|.|..|.|.||......|..:|..||.|:.:|..|..|.|:||...|..::
 Worm   638 TLNSIDYTAALEIDGVVGTIDASDVTTGAQMGHHSDTPVFVKETITFHGQPIAAIVATDHEIARK 702

Human   682 AAQGVKITYEELPAIITIEDAIKNNSFYGPELKIEKG------DLKKGFSEADNVVSGEIYIGGQ 740
            ||..||:.|.....|:||:.|::..||......|...      .:|..:|:.|.:|.|.|.:|||
 Worm   703 AASLVKLDYSVEKPIVTIKQALEAESFVFKHFVIHSSLNDNEQVIKSDWSKYDRIVEGSIDMGGQ 767

Human   741 EHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKRMGGGFGGKETR 805
            |||||||...|.:|. |..|:|:.:|.|.....|..|||.||:..::|..:|||:||||||||:.
 Worm   768 EHFYLETQQCIVIPH-EDDELEIIISNQCVNDVQIEVAKCLGMAQHKISTKVKRIGGGFGGKEST 831

Human   806 STVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGN 870
            ..:::...:|||.|.|||::...:|.:||.|||.||||..:||:...:.|..:.|:....||.|:
 Worm   832 GAILAVPASLAAKKFGRPMKFKFERFDDMAITGTRHPFTLQYKLAVDENGKFLDLDYTALSNSGH 896

Human   871 TQDLSQSIMERALFHMDNCYKIPNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTC 935
            |.|||..:|:||:.|.||.||..|...||::|||||.||||||||||||||...|..:..||...
 Worm   897 TIDLSMGVMQRAMVHADNVYKFENADITGKMCKTNLASNTAFRGFGGPQGMFGTEIMVKHVAEKF 961

Human   936 GMPAEEVRRKNLYKEGDLTHFNQKLEGFTLPRCWEECLASSQYHARKSEVDKFNKENCWKKRGLC 1000
            |...:|||.||.|||||.|.|...|....:.|.|:||..:|.|..|..||.|||..|.::|||:.
 Worm   962 GFNHDEVRVKNFYKEGDCTPFGMHLNQCNVTRTWDECRKNSDYDNRLEEVKKFNDSNKFRKRGIY 1026

Human  1001 IIPTKFGISFTVPFLNQAGALLHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIYIS 1065
            :.||:|||.|.:..|||||||:.||||||||::|||.|||||||||::|:|:|.|:||..:|:|.
 Worm  1027 LTPTRFGIGFGLKQLNQAGALVLVYTDGSVLVSHGGMEMGQGLHTKILQIAARCLEIPIERIHIH 1091

Human  1066 ETSTNTVPNTSPTAASVSADLNGQAVYAACQTILKRLEPYKKKNPSGSWEDWVTAAYMDTVSLSA 1130
            :|||:.|||.|.|||||.:|:||.||..||:.|.:|||.:||.:|:|:|:|||.|||:|.|||||
 Worm  1092 DTSTDKVPNASATAASVGSDMNGLAVQDACRQINERLERFKKLDPNGTWDDWVKAAYVDRVSLSA 1156

Human  1131 TGFYRTPNLGYSFETNSG-NPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIG 1194
            :||....:....|....| ..|.|..||.||.|||||||||||..||||||||||.|||||||||
 Worm  1157 SGFGIIHHEPVDFFNGKGAELFGYSVYGTACCEVEIDCLTGDHHLLRTDIVMDVGESLNPAIDIG 1221

Human  1195 QVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKKAIYASKA 1259
            |:||||:||.||||:||:...|:|...||||..||||:....|..|.||||.:..||..|::|||
 Worm  1222 QIEGAFIQGYGLFTMEEIKIRPDGIRLTRGPGNYKIPSADDAPRHFNVSLLGNSSNKMGIFSSKA 1286

Human  1260 VGEPPLFLAASIFFAIKDAIRAARAQHTGNNVKELFRLDSPATPEKIRNACVDKFTTLCVTGVPE 1324
            :|||||||.:..||||::|:||.|.|: ||  .:.|...||||||:||.||.| |.|..|..:||
 Worm  1287 IGEPPLFLGSCAFFAIREAVRAYRIQN-GN--ADYFVFHSPATPERIRMACED-FVTSHVPELPE 1347

Human  1325 --NCKPWSVRV 1333
              ...||...|
 Worm  1348 EGTYTPWITSV 1358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XDH	NP_000370.2	PLN02906	23..1319	CDD:215491	629/1338 (47%)
xdh-1	NP_502747.1	PLN02906	34..1340	CDD:215491	628/1335 (47%)