Protein Alignment XDH and xdh

DIOPT Version :10

• Sequence 1: NP_000370.2
• Gene: XDH / 7498
• HGNCID: 12805
• Length: 1333
• Species: Homo sapiens
• Sequence 2: XP_031758260.1
• Gene: xdh / 100497499
• XenbaseID: XB-GENE-956800
• Length: 1335
• Species: Xenopus tropicalis
• Alignment Length: 1336
• Identity: 933/1336 - (69%)
• Similarity: 1101/1336 - (82%)
• Gaps: 14/1336 - (1%)

Human     4 DKLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKIVHF 68
            |:|:|||||:||:||||||..|||.||||||||.|||||||||||||||||:|::::.|::|:|:
 Frog     8 DQLLFFVNGKKVIEKNADPGMTLLTYLRRKLGLPGTKLGCGEGGCGACTVMVSRFNQFQDRILHY 72

Human    69 SANACLAPICSLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPE 133
            |.||||||||||||.||||||||||:||||||:|||||||||||||||||||||||||||||.||
 Frog    73 SVNACLAPICSLHHTAVTTVEGIGSSKTRLHPIQERIAKSHGSQCGFCTPGIVMSMYTLLRNTPE 137

Human   134 PTMEEIENAFQGNLCRCTGYRPILQGFRTFARDGGCCGGDGNNPNCCMNQKK-DHSVSLSPSLFK 197
            |||::|:|||||||||||||||||:||:||.:: ||||....| .||.:..: :..:|:|.:||.
 Frog   138 PTMDDIDNAFQGNLCRCTGYRPILEGFKTFTKE-GCCGNKTEN-GCCRDMNRVNEDISVSSALFD 200

Human   198 PEEFTPLDPTQEPIFPPELLRLKDTPRKQLRFEGERVTWIQASTLKELLDLKAQHPDAKLVVGNT 262
            |.||.|||||||.|||||||..|::|.|.|.|:|..|||:|.|.|:|||.||||:||||||||||
 Frog   201 PSEFRPLDPTQEVIFPPELLIYKNSPPKSLCFKGGNVTWLQPSNLEELLALKAQYPDAKLVVGNT 265

Human   263 EIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLSIVEKTLVDAVAKLPAQKTEVF 327
            |:|||.|||||.:|:|:.|..:|:||.:||..:||.|||||.|:.:|:.|..|||.||..:||||
 Frog   266 EVGIETKFKNMHYPVIIAPGLVPDLNIIEHKEEGIYFGAACSLATMEEVLRKAVAHLPDYQTEVF 330

Human   328 RGVLEQLRWFAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVSRGTRRTVQMDHTFFPG 392
            ||.|||||||||:|:::||::||||:||||||||||||||||.||.:.|:...|.|:||.|||.|
 Frog   331 RGALEQLRWFAGQQIRNVAAIGGNIMTASPISDLNPVFMASGTKLYIFSKDGNRMVKMDGTFFTG 395

Human   393 YRKTLLSPEEILLSIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTTEVQELALCYG 457
            ||:|:|.|||||||||||||::.|||||||||||||||||.||||||||||.|:.:|:.:.|.||
 Frog   396 YRRTILRPEEILLSIEIPYSKKWEYFSAFKQASRREDDIAIVTSGMRVLFKAGSPQVESIQLSYG 460

Human   458 GMANRTISALKTTQRQLSKLWKEELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTLSFFFKFYLT 522
            |||..|:.|..|......|.|.::|||..|..||:|:.|.|..|||||::|.||.||||||||||
 Frog   461 GMAPITVMAKNTCTELAGKYWDDKLLQSACRLLAKEMALSPSVPGGMVEYRQTLALSFFFKFYLT 525

Human   523 VLQKL-----GQENLEDKCGKLDPTFASATLLFQKDPPADVQLFQEVPKGQSEEDMVGRPLPHLA 582
            |.:||     |..|..:   .|.|...|||.||.|..|..|||:|||||||.||||||||:.||:
 Frog   526 VHKKLALDLNGNNNFAE---TLSPKDESATELFHKSHPCSVQLYQEVPKGQKEEDMVGRPMVHLS 587

Human   583 ADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSNIT 647
            |..||:||||||||:|.|||||.|.|:|||:|||:|.||||.||...||||.|:.|:||||||:|
 Frog   588 AIKQATGEAVYCDDMPLYENELYLVLITSTKAHARIISIDTEEAALTPGFVRFLFANDVPGSNVT 652

Human   648 GICNDETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIKNNSFYGPE 712
            |..:|||:||:|.||||||:||.|||||.|:.||||:.||:.||||..||||::||:..||:.|.
 Frog   653 GFAHDETIFAEDLVTCVGHVIGGVVADTQENAQRAAKRVKVLYEELTPIITIQEAIEQESFHQPI 717

Human   713 LKIEKGDLKKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFV 777
            .|:|.||::|||.||:::|.|||||||||||||||:|:|||||.|.|||||||||||..|||:.|
 Frog   718 KKMEDGDIEKGFKEAEHIVEGEIYIGGQEHFYLETNCSIAVPKEEDGEMELFVSTQNATKTQNCV 782

Human   778 AKMLGVPANRIVVRVKRMGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGRHP 842
            |..|||.:|:||||||||||||||||:|||:|||::|:||:||||||||||||||||||||||||
 Frog   783 AHALGVSSNKIVVRVKRMGGGFGGKESRSTIVSTSIAVAAHKTGRPVRCMLDRDEDMLITGGRHP 847

Human   843 FLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDNCYKIPNIRGTGRLCKTNLP 907
            :|.||||||||.|.:.||:|.:::|.||:.|||..|::|.||||||.||||||||.|.|||||||
 Frog   848 YLGRYKVGFMKNGKITALDVSYYANAGNSVDLSHGIIDRTLFHMDNAYKIPNIRGRGYLCKTNLP 912

Human   908 SNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLTHFNQKLEGFTLPRCWEEC 972
            |||||||||||||||:||.||:.:..|||:|||:||..|:|.|||||||.|:||..|:.||||||
 Frog   913 SNTAFRGFGGPQGMLVAEAWMNHIVQTCGLPAEQVRELNMYSEGDLTHFTQQLESCTVRRCWEEC 977

Human   973 LASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSVLLTHGGT 1037
            |..:.||.||..:::||:::.|||||:.||||||||||||.||||:|||:|||||||||||||||
 Frog   978 LKQANYHERKRSIEEFNRQHRWKKRGIAIIPTKFGISFTVAFLNQSGALVHVYTDGSVLLTHGGT 1042

Human  1038 EMGQGLHTKMVQVASRALKIPTSKIYISETSTNTVPNTSPTAASVSADLNGQAVYAACQTILKRL 1102
            |||||||||||||||:||.||||:|:||||||||||||||||||||:||||.|::.|||.||:||
 Frog  1043 EMGQGLHTKMVQVASKALGIPTSRIFISETSTNTVPNTSPTAASVSSDLNGMAIFNACQKILQRL 1107

Human  1103 EPYKKKNPSGSWEDWVTAAYMDTVSLSATGFYRTPNLGYSFETNSGNPFHYFSYGVACSEVEIDC 1167
            |||:..||:|.||.|::|||:|.|:|||||||:.|.:||..|.|.|.|.:|||||||||||||||
 Frog  1108 EPYRNSNPNGPWESWISAAYLDRVNLSATGFYKIPGIGYDMEKNEGRPSNYFSYGVACSEVEIDC 1172

Human  1168 LTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPA 1232
            |||||||||||||||||||||||||||||||||||||||||||||.|||:|.|:||||..|||||
 Frog  1173 LTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELKYSPDGILYTRGPGMYKIPA 1237

Human  1233 FGSIPIEFRVSLLRDCPNKKAIYASKAVGEPPLFLAASIFFAIKDAIRAARAQHTGNNVKELFRL 1297
            ||.|||||.|||||:|||.||||:|||||||||||::|||||||:||.||||:   :.:...|||
 Frog  1238 FGDIPIEFNVSLLRNCPNSKAIYSSKAVGEPPLFLSSSIFFAIKEAIMAARAE---SGITGAFRL 1299

Human  1298 DSPATPEKIRNACVDKFTTLCVTGVPENCKPWSVRV 1333
            |||||||:|||||||.||.|.....|....||::||
 Frog  1300 DSPATPERIRNACVDDFTKLIPVPEPGTFLPWAIRV 1335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XDH	NP_000370.2	PLN02906	23..1319	CDD:215491	913/1301 (70%)
xdh	XP_031758260.1	PLN02906	28..1318	CDD:215491	911/1297 (70%)