DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WT1 and dar1

DIOPT Version :9

Sequence 1:	NP_077744.4	Gene:	WT1 / 7490	HGNCID:	12796	Length:	522	Species:	Homo sapiens
Sequence 2:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster

Alignment Length:	443	Identity:	108/443 - (24%)
Similarity:	148/443 - (33%)	Gaps:	158/443 - (35%)

- Green bases have known domain annotations that are detailed below.

Human    50 AAEASAERLQGRRSRGASGSEPQQMGSDVRDLNALL-PAVPSLGGGGGCALPVSGAAQWA----- 108
            :|.|||............|::.||.....:.|..|. ||.||.......::..|.|:..:
  Fly   454 SAAASATASATATPTAQLGAQQQQQQQQQQQLQQLCPPAAPSTPSTSSSSISSSSASSASRHMFV 518

Human   109 -----PVLDFAPPGASAYGSLGGPAPPPAPPPPPPPPPHSFIKQEPSWGGAEPHEEQCLSAFTVH 168
                 |..|...||:|...:....|......||||                             :
  Fly   519 PPLTPPSSDPGSPGSSMVAAAAAAAAQRRTTPPPP-----------------------------Y 554

Human   169 FSGQFTGTAGACRYGPFGPPPPSQASSGQARMFPNAPYLPSCLESQPAIRNQGYSTVTFDGTPSY 233
            ..|...|.        ..|||..|...|.|....|     ||..:        .:|:|
  Fly   555 QQGHVMGL--------INPPPTLQLLGGAATGSNN-----SCTTT--------LTTLT------- 591

Human   234 GHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDN 298
                       |..:.:.:....||..:.:||   |||                    ||.||
  Fly   592 -----------PASAIQQQQQQPQQQQVPQQQ---PPP--------------------TPRSS-- 620

Human   299 LYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESDNHTTPILCGAQYRIHT 363
                              |...:|             ..|:|..|..:  |...::.....|.:.
  Fly   621 ------------------GGGRRG-------------RHSHHQPGTAA--HIASLMSVRTVRYNR 652

Human   364 HGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQC 428
                                 |:..|..::|...|.:.||:|.|.|.|||:.|.|.|||||||.|
  Fly   653 ---------------------RNNPELEKRRIHHCDFVGCSKVYTKSSHLKAHQRIHTGEKPYTC 696

Human   429 DFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGK 481
            .:.:||.||:|||:|.||.|:|||.|||:|..|:|.|:|||||..|.:.|..|
  Fly   697 QWPECEWRFARSDELTRHYRKHTGAKPFKCIVCERSFARSDHLALHMKRHLPK 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WT1	NP_077744.4	WT1	74..394	CDD:308009	52/330 (16%)
		COG5048	386..>514	CDD:227381	50/96 (52%)
		C2H2 Zn finger	401..420	CDD:275368	10/18 (56%)
		C2H2 Zn finger	428..450	CDD:275368	12/21 (57%)
		C2H2 Zn finger	458..478	CDD:275368	10/19 (53%)
		C2H2 Zn finger	489..511	CDD:275368
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	38/103 (37%)
		C2H2 Zn finger	671..688	CDD:275368	9/16 (56%)
		zf-H2C2_2	680..707	CDD:290200	16/26 (62%)
		C2H2 Zn finger	696..718	CDD:275368	12/21 (57%)
		zf-H2C2_2	710..735	CDD:290200	14/24 (58%)
		C2H2 Zn finger	726..746	CDD:275368	10/19 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010