DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WT1 and Kr

DIOPT Version :9

Sequence 1:	NP_077744.4	Gene:	WT1 / 7490	HGNCID:	12796	Length:	522	Species:	Homo sapiens
Sequence 2:	NP_001261181.1	Gene:	Kr / 38012	FlyBaseID:	FBgn0001325	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	420	Identity:	112/420 - (26%)
Similarity:	157/420 - (37%)	Gaps:	138/420 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   145 IKQEPSWGGAEPHEEQCLSAFTVHFSGQFTGTAGACRY-----------GPFGPPPPSQ--ASSG 196
            ||||      :.|.::.:| .:...|...:.|:.|..|           ..||...|:|  |::.
  Fly    21 IKQE------DVHLDRSMS-LSPPMSANTSATSAAAIYPAMGLQQAAAASAFGMLSPTQLLAANR 78

Human   197 QARMFPNAPYLPSCLESQPAIRNQGYSTVTFDGTPSYGHTPSHHAAQFP-----NHSFKHEDPMG 256
            ||..|                                       .||.|     |..|.| :|..
  Fly    79 QAAAF---------------------------------------MAQLPMSTLANTLFPH-NPAA 103

Human   257 QQGSLGEQQYSVPP-------PVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLE------- 307
            ..|:...|| |:||       |....|:|..:..||....|.:|.|:...::...:..
  Fly   104 LFGAWAAQQ-SLPPQGTHLHSPPASPHSPLSTPLGSGKHPLNSPNSTPQHHEPAKKARKLSVKKE 167

Human   308 -----CMTWNQM--NLGATLKGVAAGSSSSVKWTEGQSNH------------STGYESDNHTTPI 353
                 .|:.|.|  ..|..:...::|||.:       |.|            |.....|...|..
  Fly   168 FQTEISMSVNDMYHTSGGPISPPSSGSSPN-------STHDGAGGNAGCVGVSKDPSRDKSFTCK 225

Human   354 LCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSR 418
            :|...:     |....:|:..|            :.|.|| ||.|  |.|:||:.:..||:.|.|
  Fly   226 ICSRSF-----GYKHVLQNHER------------THTGEK-PFEC--PECHKRFTRDHHLKTHMR 270

Human   419 KHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGKTS 483
            .|||||||.|  ..|:|:|.:...|:||.|.|||.:|:.|:.|..|||.|:.||:|...|.|
  Fly   271 LHTGEKPYHC--SHCDRQFVQVANLRRHLRVHTGERPYTCEICDGKFSDSNQLKSHMLVHNG--- 330

Human   484 EKPFSCRWPSCQKKFARSDELVRHHNMHQR 513
            ||||.|.  .|..||.|     |||.|:.:
  Fly   331 EKPFECE--RCHMKFRR-----RHHLMNHK 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WT1	NP_077744.4	WT1	74..394	CDD:308009	57/299 (19%)
		COG5048	386..>514	CDD:227381	57/128 (45%)
		C2H2 Zn finger	401..420	CDD:275368	8/18 (44%)
		C2H2 Zn finger	428..450	CDD:275368	8/21 (38%)
		C2H2 Zn finger	458..478	CDD:275368	9/19 (47%)
		C2H2 Zn finger	489..511	CDD:275368	8/21 (38%)
Kr	NP_001261181.1	C2H2 Zn finger	224..244	CDD:275368	4/36 (11%)
		zf-H2C2_2	237..261	CDD:290200	12/38 (32%)
		C2H2 Zn finger	252..272	CDD:275368	9/21 (43%)
		zf-H2C2_2	264..289	CDD:290200	15/26 (58%)
		C2H2 Zn finger	280..300	CDD:275368	8/21 (38%)
		zf-H2C2_2	292..316	CDD:290200	11/23 (48%)
		C2H2 Zn finger	308..328	CDD:275368	9/19 (47%)
		zf-H2C2_2	321..345	CDD:290200	13/28 (46%)
		C2H2 Zn finger	336..352	CDD:275368	9/22 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910