|
Human 66 SEDISMSLSDGDVVGFDMEWPPLYNRGKLGKV----ALIQLCVSES-----KCYLFHVSSMS--- 118
|.:.:.|:.|...:|..:| |..||..: :||.....:| ||.:...:|:|
Yeast 153 SRNNNKSVIDNSSIGKQLE-----NDIKLEVIRLQGSLIMALKEQSKLLLQKCSIIESTSLSEDA 212
Human 119 --------VFPQGLKM-----LLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLK 170
:.||...| .||.:.:|....|:..|| .|.::.|...|
Yeast 213 KRLQLSRDIRPQLSNMSIRIDSLEKEIIKAKKDGMSKDQ--------SKGRSQVSSQD------- 262
Human 171 CTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRN--------- 226
::::..:|...|..:.|.|.||.:....|...|..|.|.|... |..|
Yeast 263 -------DNIISSILPSPLEYNTSSRNSNLTSTTATTVTKALAITGAKQN--ITNNTGKNSNNDS 318
Human 227 -----LEILDDTVQRFAINKEEEILL------SDMNKQLTSISEEVMDLAKHLPHAFSKLENPRR 280
:::|||... |:.:..::| |.....|...|||..:|.:. ..:.:...
Yeast 319 NNDDLIQVLDDEDD---IDCDPPVILKEGAPHSPAFPHLHMTSEEQDELTRR-----RNMRSREP 375
Human 281 VSILLKDISENLYSLRRMIIGST------NIETELRPSNNLNLLSFEDS-----TTGGVQQKQIR 334
|:..:.|..:.. ..::|.: ::| |..:.|.:.:.:|: || :.::..
Yeast 376 VNYRIPDRDDPF----DYVMGKSLRDDYPDVE---REEDELTMEAEDDAHSSYMTT---RDEEKE 430
Human 335 EHEVLIH-----VEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMS 394
|:|:|.. |.::..|||.| ...||..||..|..|..::| |......|.:|.....::|
Yeast 431 ENELLNQSDFDFVVNDDLDPTQD-TDYHDNMDVSANIQESSQEG--DTRSTITLSQNKNVQVILS 492
Human 395 -------------------LDITEHELQ---ILE--------QQSQEEYLSDI----AYKSTEHL 425
:|:.|.:|: ||: :|......||: :.|..|..
Yeast 493 SPTAQSVPSNGQNQIGVEHIDLLEDDLEKDAILDDSMSFSFGRQHMPMSHSDLELIDSEKENEDF 557
Human 426 SPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPT 490
..::|.|...|: ||.||| :.....:|....:.:.|.|.||::...:.|...|. .|.
Yeast 558 EEDNNNNGIEYL--SDSDLE----RFDEERENRTQVADIQELDNDLKIITERKLTGDNE---HPP 613
Human 491 HSKCLKMERNLGLPTKEEEEDD----------ENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFG 545
.|...|::|.....::::|||| .:::|...:.:...:.| ::|.:..|...|.
Yeast 614 PSWSPKIKREKSSVSQKDEEDDFDDDFSLSDIVSKSNLSSKTNGPTYPW---SDEVLYRLHEVFK 675
Human 546 HSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIG------LVISPLISLMED 604
...|:|.|.:.:::.| :.:|...:|.||.|||||:|.|.|. |.| :|||||||||:|
Yeast 676 LPGFRPNQLEAVNATL-QGKDVFVLMPTGGGKSLCYQLPAVV--KSGKTHGTTIVISPLISLMQD 737
Human 605 QVLQLKMSNIPACFLGS-------AQSENVLTDIKLGKYRIVYVTPEYCSGN---MGLLQQLEAD 659
||..|...||.|....| .|:.|:..: |...:||::||..|.: ...:.:|.||
Yeast 738 QVEHLLNKNIKASMFSSRGTAEQRRQTFNLFIN---GLLDLVYISPEMISASEQCKRAISRLYAD 799
Human 660 IGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQ 724
..:..|.||||||:|.||||||..:::|...|...|.:|::|||||||..:|.||:..|.|:.|.
Yeast 800 GKLARIVVDEAHCVSNWGHDFRPDYKELKFFKREYPDIPMIALTATASEQVRMDIIHNLELKEPV 864
Human 725 ITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPT-IIYCPSRKMTQQVTGELRKLN 788
.....|:|.|||.||.:||.|.: |.:..:....|:..| ||||.|:|..:|.:.::::..
Yeast 865 FLKQSFNRTNLYYEVNKKTKNTI-----FEICDAVKSRFKNQTGIIYCHSKKSCEQTSAQMQRNG 924
Human 789 LSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIG 853
:.|..|||||....|..:...:..||||.:.||:||||||:|.|:|.|.|:..|:.:|.||||.|
Yeast 925 IKCAYYHAGMEPDERLSVQKAWQADEIQVICATVAFGMGIDKPDVRFVYHFTVPRTLEGYYQETG 989
Human 854 RAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEK--FRLYKLKMMAKMEKYL----HSSRCRRQI 912
||||||..|.|...::..|| |.:.|.|:.:| .|..|.|.:.|:::.: :.:.|||::
Yeast 990 RAGRDGNYSYCITYFSFRDI---RTMQTMIQKDKNLDRENKEKHLNKLQQVMAYCDNVTDCRRKL 1051
Human 913 ILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVD-ILGEK 976
:||:|.:....|. ..|.|||||:..: .:::..|.: ..|.|::..|: |..|:
Yeast 1052 VLSYFNEDFDSKL------CHKNCDNCRNSAN---VINEERDVT----EPAKKIVKLVESIQNER 1103
Human 977 FGIGLPILF----LRGSNSQRLA----DQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSR 1033
:.|:: .:||.|.::. |....| |.||...:|..:.....|||...|.|.|.
Yeast 1104 ----VTIIYCQDVFKGSRSSKIVQANHDTLEEH---GIGKSMQKSEIERIFFHLITIRVLQEYSI 1161
Human 1034 YN------KFMKICALTKK---GRNWLHKANT-------ESQSLILQANEELCPKKLLLPSSKTV 1082
.| .::|:....|| |:..:....| .|.|...||||:..| ::...|.|:
Yeast 1162 MNNSGFASSYVKVGPNAKKLLTGKMEIKMQFTISAPNSRPSTSSSFQANEDNIP--VIAQKSTTI 1224
Human 1083 SS----------GTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKA 1137
.. ..|||. :.|:| .||.:
Yeast 1225 GGNVAANPPRFISAKEHL-----------------RSYTY-------GGSTM------------- 1252
Human 1138 YSSSQPVI--------SAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPT- 1193
.||.|:. |.||.....:.|.:|.|......|:|..|......:.||..||.:.|.
Yeast 1253 -GSSHPITLKNTSDLRSTQELNNLRMTYERLRELSLNLGNRMVPPVGNFMPDSILKKMAAILPMN 1316
Human 1194 --------TVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKN 1250
|||:..| :.|....:...||......::.:|...:..:
Yeast 1317 DSAFATLGTVEDKYR-------------------RRFKYFKATIADLSKKRSSEDHEKYDTILND 1362
Human 1251 KICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKI 1315
:....:.:.: ..||:|........|.:|::| .|.::|
Yeast 1363 EFVNRAAASS-------------NGIAQSTGTKSKFFGANLNEA---------------KENEQI 1399
Human 1316 IADVIRNP-PVNSDMSK 1331
|..:.::. |.|:..||
Yeast 1400 INQIRQSQLPKNTTSSK 1416
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