Protein Alignment WRN and wrn

DIOPT Version :10

• Sequence 1: NP_000544.2
• Gene: WRN / 7486
• HGNCID: 12791
• Length: 1432
• Species: Homo sapiens
• Sequence 2: XP_012810306.2
• Gene: wrn / 734043
• XenbaseID: XB-GENE-992875
• Length: 1433
• Species: Xenopus tropicalis
• Alignment Length: 1498
• Identity: 761/1498 - (50%)
• Similarity: 999/1498 - (66%)
• Gaps: 142/1498 - (9%)

Human     9 TAQQRKCPEWMNVQNKRCAVEERKACV-RKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMS 72
            |:.|||.||||:||.|..:::::|..: :|::.||:||:|:|.|||||||:.:|||.|||||..|
 Frog     2 TSLQRKLPEWMSVQQKEDSIDDKKKSLWKKNIVEDNLPYLKFNGSIVYSYEGNDCSLLSEDIRSS 66

Human    73 LSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAG 137
            |.:.||:|||:||||:|.:||.|||||||:||||.||||||:|.|:.||:||:.|||:::|||.|
 Frog    67 LQEEDVLGFDIEWPPIYTKGKTGKVALIQVCVSEKKCYLFHISPMAGFPKGLRRLLEDESVKKVG 131

Human   138 VGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSK 202
            ||||||||||:.|:::|||.|:||::|||:||:|.|.||||.|||||..||||||.|||||||..
 Frog   132 VGIEGDQWKLMSDYELKLKGFIELSEVANQKLRCKEKWSLNGLVKHLFKKQLLKDSSIRCSNWDI 196

Human   203 FPLTEDQKLYAATDAYAGFIIYRNLEILD--DTVQRFAINKEEEILLSDMNKQLTSISEEVMDLA 265
            |||:.|||||||:|||||.:||:.||.:|  :.|. |.:::........:.:|||.:|...|||.
 Frog   197 FPLSTDQKLYAASDAYAGLLIYQKLECMDAHEKVS-FCVSRVGVADFEGIKRQLTDLSNGFMDLV 260

Human   266 KHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFED-STTGGVQ 329
            |.:|.:|.......|...:|:|:||.|..||.::..::..|     .|.|.....|| |.....|
 Frog   261 KDVPSSFGHSTGALRAVAILEDLSEKLEELRSIVKEASKGE-----GNGLLCHDSEDCSEEDKYQ 320

Human   330 QKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMS 394
            ...:...|:|.       :..:|:           ...|.|.:...|..::..:|::.
 Frog   321 SINLASKELLA-------ENKIDY-----------KNAESKNNKDVDCCQNENMKQDF------- 360

Human   395 LDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNEN 459
            |.|:|.||.::|::..|:.:.. ..||.|||...:.|.:.||:|||||:.|.|::|.|...||
 Frog   361 LGISEEELYMMERKDDEKQIKP-GQKSNEHLYDTNEEKNMSYIIESDEEFESEIIKSLEDLDN-- 422

Human   460 DTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGL-PTKEEEEDDENEANEG--EE 521
                              |:|.....:|..|           || |.|..:...:.|.:||  ||
 Frog   423 ------------------SIEEAIGTSVHQT-----------GLIPAKSVDTVADEEEDEGIEEE 458

Human   522 DDDKDFLW----PAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQ 582
            |||.|  |    |.||.|||:|||.|||||||||||||||||||.|||||:.|||||||||||:|
 Frog   459 DDDDD--WDPSIPEPNAEQVSCLKTYFGHSSFKPVQWKVIHSVLRERRDNLVVMATGYGKSLCYQ 521

Human   583 YPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCS 647
            :.|||...||:||.|||||||||||||:|||||:||||||||:|||.|:|.|:.|::|:|||:||
 Frog   522 FAPVYTSGIGIVICPLISLMEDQVLQLEMSNIPSCFLGSAQSKNVLQDVKAGRMRVIYMTPEFCS 586

Human   648 GNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIRE 712
            |.:.|||.|:...||||||:||||||||||||||.::|.|||||..||.|||||||||||.||||
 Frog   587 GGISLLQDLDNRYGITLIAIDEAHCISEWGHDFRSAYRSLGSLKRMLPTVPIVALTATASPSIRE 651

Human   713 DIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLV-KTSSHWEFEGPTIIYCPSRKM 776
            ||.:.|:|.|||||||.||||||||:|.:||.||..|||.||: |..|.|||||.||:|||:||.
 Frog   652 DISKSLSLHNPQITCTSFDRPNLYLDVAKKTTNISTDLQQFLIKKQGSGWEFEGATIVYCPTRKT 716

Human   777 TQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGA 841
            ::|||.||.||.::||||||||....|:|:||||:|||||||:||:||||||||.|||:||||||
 Frog   717 SEQVTAELTKLGIACGTYHAGMGIKQRRDVHHRFMRDEIQCVVATVAFGMGINKPDIRKVIHYGA 781

Human   842 PKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSS 906
            ||:||||||||||||||||.|.||.||..||||.|||:|.||.|..||.|||||:.||||||:||
 Frog   782 PKEMESYYQEIGRAGRDGLPSCCHALWTQADINFNRHMLGEIPNNSFREYKLKMLTKMEKYLNSS 846

Human   907 RCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVD 971
            .|||:||||||||||::|||.||||||||||||::||....|::|:||...:||.||:|.:||||
 Frog   847 NCRRKIILSHFEDKQLRKASSGIMGTEKCCDNCKTRLRFNISINDTEDNLQEFGQQAYKFISAVD 911

Human   972 ILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNK 1036
            |||:|||.|:|:||||||.||||.|::|.|.||..||||||::||..:||||:||:|.|.|.:.|
 Frog   912 ILGQKFGTGVPVLFLRGSTSQRLPDRFRHHPLFSCGKDQTEAFWKVLARQLISEGYLQESSGHTK 976

Human  1037 FMKICALTKKGRNWLHKA-NTESQSLILQANEELCPKKLL-------LPSSKTVSSGTKEHCYNQ 1093
            |..||.||.||.|||.|| |.:..||:|.:|:|||.::..       :||..::......:..:.
 Frog   977 FSTICGLTSKGTNWLMKASNQQHPSLLLPSNDELCLRRTTVSNSISRVPSHSSMIPHASPNTRSS 1041

Human  1094 VPVELSTEKKSNLEKLYSYKPCDKISSGSNISK-KSIMVQSPEKAYSSSQPVISAQEQETQIVLY 1157
            :| :...||.|..|| :||:...|:|:..::|| .|:.:|:|.|...:::|.:|.:|.|.|..||
 Frog  1042 IP-KAGPEKISLKEK-FSYQEAGKLSTAVDVSKSSSLKLQTPCKPLQAAEPDVSPKEMELQTALY 1104

Human  1158 GKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHF 1222
            |:||.||||.|::.|:|||:|||||:||||||:||||:||:|::|||||.|:||||||:||:|.|
 Frog  1105 GRLVVARQKIASERDIPPAVLATNKVLVDMAKLRPTTIENMKKLDGVSEAKSAMLAPLVEVVKEF 1169

Human  1223 CQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTI 1287
            |..||::.|:||.:..|.|..:|...:....||.:|..::||||||:.:.||.:|::|.|.:..:
 Frog  1170 CIANSLKMDIFSRSGSQSELTSSTQREQDSTTLPESQRMSYSLFQEQNLSLKKVADARCLSMAAV 1234

Human  1288 GMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAI 1352
            ||||.||:|||..:|::||||||.::|:|.|.|:|||:|||:|....||..:|.|||:|||.|||
 Frog  1235 GMHLWQALKAGYSVDVQRAGLTPGIRKLIIDNIKNPPINSDLSSFKAIRESIPANIDSYLIRMAI 1299

Human  1353 EILKHGPDSGLQPSCD---------------------------------VNKRRCFPGSEEICSS 1384
            .:|:....:|.|...|                                 :.|:...|.:.|:..:
 Frog  1300 ALLEKEESNGAQGQLDLPTQKTLVKLEEQPKNISVENIKHKATMNNSLWIEKKPTQPTTAELEET 1364

Human  1385 SKR-----------------SKEEVGINTETSSAERKRRLPVWF--AKG-SDTSKKLMDKT-KRG 1428
            ..:                 ..||:...:::.:...||:||.||  ||| :.|:.....|| |:.
 Frog  1365 KAKPLAPIMLASWNEPSLDADTEELFSESQSYTTTPKRKLPQWFGPAKGNAGTNAVKKAKTGKKK 1429

Human  1429 GLF 1431
            |:|
 Frog  1430 GIF 1432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WRN	NP_000544.2	Interaction with WRNIP1. /evidence=ECO:0000250|UniProtKB:O09053	2..277		156/270 (58%)
		KBM 1. /evidence=ECO:0000305|PubMed:27063109	11..23		8/11 (73%)
		RNaseD_like	61..229	CDD:176650	116/167 (69%)
		PTZ00341	<156..480	CDD:173534	114/326 (35%)
		2 X 27 AA tandem repeats of H-L-S-P-N-D-N-E-N-D-T-S-Y-V-I-E-S-D-E-D-L-E-M-E-M-L-K	424..477		16/52 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	498..529		13/33 (39%)
		recQ_fam	538..1010	CDD:129701	340/472 (72%)
		DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	668..671		2/2 (100%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:20159463	987..993		4/5 (80%)
		HRDC	1156..1229	CDD:128635	51/72 (71%)
		HTH_40	1258..1352	CDD:464189	49/93 (53%)
		KBM 2. /evidence=ECO:0000305|PubMed:27063109	1403..1412		6/10 (60%)
		XLM. /evidence=ECO:0000305|PubMed:27063109	1419..1432		5/14 (36%)
wrn	XP_012810306.2	WRN_exo	55..222	CDD:176653	115/166 (69%)
		recQ_fam	477..950	CDD:129701	340/472 (72%)
		HRDC	1098..1176	CDD:128635	53/77 (69%)
		HTH_40	1205..1299	CDD:464189	49/93 (53%)