DRSC/TRiP Functional Genomics Resources

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Protein Alignment WRN and WRNexo

DIOPT Version :10

Sequence 1:NP_000544.2 Gene:WRN / 7486 HGNCID:12791 Length:1432 Species:Homo sapiens
Sequence 2:NP_001163646.1 Gene:WRNexo / 42208 FlyBaseID:FBgn0038608 Length:354 Species:Drosophila melanogaster


Alignment Length:267 Identity:85/267 - (31%)
Similarity:132/267 - (49%) Gaps:40/267 - (14%)


- Green bases have known domain annotations that are detailed below.


Human    10 AQQRKCPEWMNVQNKRCAVEERKACVR---------KSVFED-----------DLPFLEFTGSIV 54
            |.:||..:..:|:.::.|:||.....|         :|:.||           .|||:::.|:|.
  Fly    67 AAKRKNLDTPDVKTEKLAMEEENPPKRRSSRLTRSTRSMAEDGSPSPEKEKPEKLPFIKYKGAIK 131

Human    55 YSYDASDCSFLSEDIS--MSLSDGDVV--GFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVS 115
            |..::.|.:..::|:.  :.....:||  .||||||..:..|. ||.|:||:||.|..||::.::
  Fly   132 YFTESQDIAASADDVLQWVEKQKDEVVPMAFDMEWPFSFQTGP-GKSAVIQICVDEKCCYIYQLT 195

Human   116 SMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDF-DIKLKNFVE-LTDVANKKLKCTET---- 174
            ::...|..|..|:.:..|:..||.|:.|..||.||| ::..:..:| ..|:.   |.|.|.    
  Fly   196 NVKKLPAALVALINHPKVRLHGVNIKNDFRKLARDFPEVTAEPLIEKCVDLG---LWCNEVCETG 257

Human   175 --WSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRF 237
              |||..|...:..|.:.|.|.:|.|.|...||.|:|.:|||.|.|.|.:|||.||    ..::.
  Fly   258 GRWSLERLTNFIAKKAMDKSKKVRMSKWHVIPLDENQLMYAAIDVYIGQVIYRELE----RREKV 318

Human   238 AINKEEE 244
            .|..|||
  Fly   319 KIKNEEE 325

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WRNNP_000544.2 Interaction with WRNIP1. /evidence=ECO:0000250|UniProtKB:O09053 2..277 85/267 (32%)
KBM 1. /evidence=ECO:0000305|PubMed:27063109 11..23 3/11 (27%)
RNaseD_like 61..229 CDD:176650 63/179 (35%)
PTZ00341 <156..480 CDD:173534 34/96 (35%)
2 X 27 AA tandem repeats of H-L-S-P-N-D-N-E-N-D-T-S-Y-V-I-E-S-D-E-D-L-E-M-E-M-L-K 424..477
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 498..529
recQ_fam 538..1010 CDD:129701
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 668..671
Interaction with DNA. /evidence=ECO:0000269|PubMed:20159463 987..993
HRDC 1156..1229 CDD:128635
HTH_40 1258..1352 CDD:464189
KBM 2. /evidence=ECO:0000305|PubMed:27063109 1403..1412
XLM. /evidence=ECO:0000305|PubMed:27063109 1419..1432
WRNexoNP_001163646.1 PLN02967 16..>114 CDD:215521 11/46 (24%)
WRN_exo 142..314 CDD:176653 63/179 (35%)
Blue background indicates that the domain is not in the aligned region.

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