Protein Alignment WRN and Wrn

DIOPT Version :10

• Sequence 1: NP_000544.2
• Gene: WRN / 7486
• HGNCID: 12791
• Length: 1432
• Species: Homo sapiens
• Sequence 2: NP_035851.3
• Gene: Wrn / 22427
• MGIID: 109635
• Length: 1401
• Species: Mus musculus
• Alignment Length: 1434
• Identity: 1004/1434 - (70%)
• Similarity: 1175/1434 - (81%)
• Gaps: 40/1434 - (2%)

Human     6 LETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDIS 70
            :|||:.|||.||||::|::|||.|| ||||:|||.||:||||||.|||||||:||||||||||||
Mouse     1 METTSLQRKFPEWMSMQSQRCATEE-KACVQKSVLEDNLPFLEFPGSIVYSYEASDCSFLSEDIS 64

Human    71 MSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKK 135
            |.|||||||||||||||:|..||..:||:||||||||||||||:|||||||||||||||||::||
Mouse    65 MRLSDGDVVGFDMEWPPIYKPGKRSRVAVIQLCVSESKCYLFHISSMSVFPQGLKMLLENKSIKK 129

Human   136 AGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNW 200
            |||||||||||||||||:||::|||||||||:||||.||||||.||||:||||||||||||||||
Mouse   130 AGVGIEGDQWKLLRDFDVKLESFVELTDVANEKLKCAETWSLNGLVKHVLGKQLLKDKSIRCSNW 194

Human   201 SKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLA 265
            |.||||||||||||||||||.|||:.|..|.||.|.||:||.||.|..:|.|||.|||||:.|||
Mouse   195 SNFPLTEDQKLYAATDAYAGLIIYQKLGNLGDTAQVFALNKAEENLPLEMKKQLNSISEEMRDLA 259

Human   266 KHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQ 330
            ...|.....||..:||.::||.|||||.|||::|.|.||.||.|:|.::.||||.|||...|.::
Mouse   260 NRFPVTCRNLETLQRVPVILKSISENLCSLRKVICGPTNTETRLKPGSSFNLLSSEDSAAAGEKE 324

Human   331 KQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSL 395
            |||.:|.....:::|.|||.||.|.|.:..||..|:|::::...|:.:|||.|:|:|||.|::.
Mouse   325 KQIGKHSTFAKIKEEPWDPELDSLVKQEEVDVFRNQVKQEKGESENEIEDNLLREDMERTCVIP- 388

Human   396 DITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNEND 460
            .|:|:|||.||||::||..:|::::.:|                           ||||||:|||
Mouse   389 SISENELQDLEQQAKEEKYNDVSHQLSE---------------------------HLSPNDDEND 426

Human   461 TSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDK 525
            :||:||||||||||||||||||||..||||||..|:|..|..|| .|||:...|||.: ||.:::
Mouse   427 SSYIIESDEDLEMEMLKSLENLNSDVVEPTHSTWLEMGTNGRLP-PEEEDGHGNEAIK-EEQEEE 489

Human   526 DFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGK 590
            |.|.|.||.:|:.|||.||||||||||||||||||||||||||.||||||||||||||||||.||
Mouse   490 DHLLPEPNAKQINCLKTYFGHSSFKPVQWKVIHSVLEERRDNVVVMATGYGKSLCFQYPPVYTGK 554

Human   591 IGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQ 655
            ||:||||||||||||||||::||:|||.||||||:|:|.|:||||||::|:|||:||||:.||||
Mouse   555 IGIVISPLISLMEDQVLQLELSNVPACLLGSAQSKNILGDVKLGKYRVIYITPEFCSGNLDLLQQ 619

Human   656 LEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNL 720
            |::.||||||||||||||||||||||.|||.|||||||||:||::||:|||||||||||:.||||
Mouse   620 LDSSIGITLIAVDEAHCISEWGHDFRSSFRMLGSLKTALPLVPVIALSATASSSIREDIISCLNL 684

Human   721 RNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLV-KTSSHWEFEGPTIIYCPSRKMTQQVTGEL 784
            ::|||||||||||||||||.||||||||||:|||| |.||.|||||||||||||||||:|||.||
Mouse   685 KDPQITCTGFDRPNLYLEVGRKTGNILQDLKPFLVRKASSAWEFEGPTIIYCPSRKMTEQVTAEL 749

Human   785 RKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYY 849
            .||||:|.||||||..|.|||:||||:|||||||:||:||||||||||||:||||||||:|||||
Mouse   750 GKLNLACRTYHAGMKISERKDVHHRFLRDEIQCVVATVAFGMGINKADIRKVIHYGAPKEMESYY 814

Human   850 QEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIIL 914
            ||||||||||||||||:||||||.|.:|:||.||.:|||||||||||.|||||||||:|||:|||
Mouse   815 QEIGRAGRDGLQSSCHLLWAPADFNTSRNLLIEIHDEKFRLYKLKMMVKMEKYLHSSQCRRRIIL 879

Human   915 SHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGI 979
            ||||||.:|||||.||||||||||||.||:||.:.::|||.|.|||||||:||||||||.|||||
Mouse   880 SHFEDKCLQKASLDIMGTEKCCDNCRPRLNHCLTANNSEDASQDFGPQAFQLLSAVDILQEKFGI 944

Human   980 GLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALT 1044
            |:|||||||||||||.|:||.|.|||.||:|.|||||..|..||.|||||||.:.||::|.|:||
Mouse   945 GIPILFLRGSNSQRLPDKYRGHRLFGAGKEQAESWWKTLSHHLIAEGFLVEVPKENKYIKTCSLT 1009

Human  1045 KKGRNWLHKANTES-QSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEK 1108
            ||||.||.:|:::| .||:||||||:.|:|:|||||..||..|.:|..||.|..|:| |:||||:
Mouse  1010 KKGRKWLGEASSQSPPSLLLQANEEMFPRKVLLPSSNPVSPETTQHSSNQNPAGLTT-KQSNLER 1073

Human  1109 LYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDV 1173
            .:|||..:|:|||:||.|||.::.||..:.|..:|.|||||.:.:..||.:||||||||||||||
Mouse  1074 THSYKVPEKVSSGTNIPKKSAVMPSPGTSSSPLEPAISAQELDARTGLYARLVEARQKHANKMDV 1138

Human  1174 PPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKP 1238
            |||||||||:|:||||||||||||:|:||||||||||:|||||||||||||..||||||.||.||
Mouse  1139 PPAILATNKVLLDMAKMRPTTVENMKQIDGVSEGKAALLAPLLEVIKHFCQVTSVQTDLLSSAKP 1203

Human  1239 QEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDL 1303
            .:||:.|...:.|.|:|.||:|:||:|||||||||.||||:|:|||...||||:||||||.|||:
Mouse  1204 HKEQEKSQEMEKKDCSLPQSVAVTYTLFQEKKMPLHSIAENRLLPLTAAGMHLAQAVKAGYPLDM 1268

Human  1304 ERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCD 1368
            ||||||||..|||.|||||||:||||.|:.|||||||||:||||||||||||:.|.||..||.||
Mouse  1269 ERAGLTPETWKIIMDVIRNPPINSDMYKVKLIRMLVPENLDTYLIHMAIEILQSGSDSRTQPPCD 1333

Human  1369 VNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKG----SDT-SKKLMDKTKRG 1428
            .:::|.||.|.|.|.|.|.|||.| ..|:.||:|.||:||.|||||    :|| |...|.|||:.
Mouse  1334 SSRKRRFPSSAESCESCKESKEAV-TETKASSSESKRKLPEWFAKGNVPSADTGSSSSMAKTKKK 1397

Human  1429 GLFS 1432
            ||||
Mouse  1398 GLFS 1401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WRN	NP_000544.2	Interaction with WRNIP1. /evidence=ECO:0000250|UniProtKB:O09053	2..277		210/270 (78%)
		KBM 1. /evidence=ECO:0000305|PubMed:27063109	11..23		7/11 (64%)
		RNaseD_like	61..229	CDD:176650	145/167 (87%)
		PTZ00341	<156..480	CDD:173534	180/323 (56%)
		2 X 27 AA tandem repeats of H-L-S-P-N-D-N-E-N-D-T-S-Y-V-I-E-S-D-E-D-L-E-M-E-M-L-K	424..477		22/52 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	498..529		12/30 (40%)
		recQ_fam	538..1010	CDD:129701	390/472 (83%)
		DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	668..671		2/2 (100%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:20159463	987..993		5/5 (100%)
		HRDC	1156..1229	CDD:128635	63/72 (88%)
		HTH_40	1258..1352	CDD:464189	73/93 (78%)
		KBM 2. /evidence=ECO:0000305|PubMed:27063109	1403..1412		5/8 (63%)
		XLM. /evidence=ECO:0000305|PubMed:27063109	1419..1432		6/12 (50%)
Wrn	NP_035851.3	Interaction with WRNIP1. /evidence=ECO:0000269|PubMed:11301316	1..271		210/270 (78%)
		KBM 1. /evidence=ECO:0000250|UniProtKB:Q14191	6..18		7/11 (64%)
		RNaseD_like	55..223	CDD:176650	145/167 (87%)
		rnd	<156..>344	CDD:130455	119/187 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	401..427		13/52 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	464..492		12/29 (41%)
		recQ_fam	502..975	CDD:129701	390/472 (83%)
		DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	632..635		2/2 (100%)
		Interaction with DNA. /evidence=ECO:0000250|UniProtKB:Q14191	952..958		5/5 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1041..1106		34/65 (52%)
		HRDC	1116..1194	CDD:128635	63/77 (82%)
		HTH_40	1223..1317	CDD:464189	73/93 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1323..1401		41/78 (53%)
		KBM 2. /evidence=ECO:0000250|UniProtKB:Q14191	1367..1376		5/8 (63%)
		XLM. /evidence=ECO:0000250|UniProtKB:Q14191	1388..1401		6/12 (50%)