Protein Alignment WNT10B and Wnt2

DIOPT Version :10

• Sequence 1: NP_003385.2
• Gene: WNT10B / 7480
• HGNCID: 12775
• Length: 389
• Species: Homo sapiens
• Sequence 2: NP_476810.1
• Gene: Wnt2 / 35975
• FlyBaseID: FBgn0004360
• Length: 352
• Species: Drosophila melanogaster
• Alignment Length: 363
• Identity: 129/363 - (35%)
• Similarity: 183/363 - (50%)
• Gaps: 51/363 - (14%)

Human    43 TANTVCLTLSGLSKRQLGLCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHS 107
            |:..:|..:.||:..|..:|...||...:..:|..:...|||||.|..|||||.:.......|
  Fly    25 TSVMLCGRIPGLTPGQRNMCREMPDALIALGEGHQLGAQECQHQFRGHRWNCSEVWQRNVFAH-- 87

Human   108 AILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKS 172
             ::....||:|:::::.:||..:||..||:.|.:.:|||..:
  Fly    88 -VIPTASREAAYTYAIASAGAAYAVTAACARGNISTCGCDVR----------------------- 128

Human   173 FPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGRQ 237
              |.....|.|:     |.:.|:||||:.|:|||.:::|.|:|:||..||.:..|.:||||.||.
  Fly   129 --HKATPTGGGT-----PDEPWKWGGCSADVDFGMRYARRFMDARELERDSRTLMNLHNNRAGRT 186

Human   238 VVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRAIFIDT--------------- 287
            :|.:.|:..|||||.||||..||||::.|.||.||..|..:..:|..:..
  Fly   187 LVKKMLRTDCKCHGVSGSCVMKTCWKSLPPFRLVGDRLMLKYQKAKTVQAVKGKRGLRLVLSRKK 251

Human   288 HNRNSGAFQPRLR-PRRLSGELVYFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCGSLCCGR 351
            |...:.|.:|.|. |:|:  ||:|.|.||::|||....||.||.||.|.:|......|..|||||
  Fly   252 HAGTARAQKPVLDWPKRM--ELIYLEASPNYCERSLQTGSQGTSGRTCQRTGHGPQSCDLLCCGR 314

Human   352 GHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK 389
            |||.....|..:|.|:|.|||.|.||||..:.....||
  Fly   315 GHNTQHIRRTTQCRCQFRWCCEVKCDECDESYEEFTCK 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WNT10B	NP_003385.2	Wnt_Wnt10b	45..389	CDD:381730	126/359 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	171..197		5/25 (20%)
Wnt2	NP_476810.1	Wnt_Wnt7	29..352	CDD:381713	126/357 (35%)