Protein Alignment WNT10B and Wnt6

DIOPT Version :10

• Sequence 1: NP_003385.2
• Gene: WNT10B / 7480
• HGNCID: 12775
• Length: 389
• Species: Homo sapiens
• Sequence 2: NP_609108.3
• Gene: Wnt6 / 34010
• FlyBaseID: FBgn0031902
• Length: 420
• Species: Drosophila melanogaster
• Alignment Length: 407
• Identity: 136/407 - (33%)
• Similarity: 194/407 - (47%)
• Gaps: 76/407 - (18%)

Human    42 LTANTVCLTLSGLSKRQLGLCLRNPDVTASAL------QGLHIAVHECQHQLRDQRWNCSALEGG 100
            |..|.:|.....|..:...:|..:     |||      .|:::...||:.|.|::||||:.|...
  Fly    29 LDPNLMCKKTRRLRGKLAEICRHD-----SALLKEIIINGINLGFRECEFQFRNRRWNCTVLRKS 88

Human   101 GRLPHHSAILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCG---WKGSGEQDRL----- 157
            .|     .||.|..||:.|..::.||||.:||..||::|:||.|.|.   .:.:|.|.::
  Fly    89 MR-----KILMRDSRETGFVNAITAAGVTYAVTKACTMGQLVECSCDKAHMRRNGGQPQMVTAAT 148

Human   158 ---------RAKLLQ----------LQALSRGKSFPHSLPSPGP-----GSSPSPG--------- 189
                     :|.:|:          .|.|||..: ..::....|     |.:..||
  Fly   149 AEAALERQQQAAMLRQQMPLQDQHPSQRLSRMNN-ASTMTDIAPVEHRGGRNRRPGGRRGRRKFW 212

Human   190 -----PQDTWEWGGCNHDMDFGEKFSRDFLDSREAPR--DIQARMRIHNNRVGRQVVTENLKRKC 247
                 |:..||||||:.:::||.:.||.|||:::..|  |:...::.|||..||..:.:.::.:|
  Fly   213 DNIKFPEGQWEWGGCSDNVNFGLRHSRVFLDAKQRQRRSDLGTLVKFHNNNAGRLAIRDAMRLEC 277

Human   248 KCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRAIFIDTHNRNSGAF---QPRLRPRRLSGELV 309
            ||||.||||..||||...|.||.|...||:|...|..:...| :..:|   .|..||.. ..:||
  Fly   278 KCHGLSGSCTVKTCWLKMPPFREVAGRLRDRYDSARKVTLRN-DGNSFMPESPHARPAN-KYQLV 340

Human   310 YFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCGSLCCGRGHN---VLRQTRVERCHCRFHWC 371
            :.:.|||||..:...|:.||:||.||.||...|.|..|||.|||.   |..||   .|.|.|.||
  Fly   341 FADDSPDFCTPNSKTGALGTQGRECNVTSSGSDRCDRLCCNRGHTRRIVEEQT---NCKCVFKWC 402

Human   372 CYVLCDECKVTEWVNVC 388
            |.|.|::|.....||.|
  Fly   403 CEVTCEKCLEHRAVNTC 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WNT10B	NP_003385.2	Wnt_Wnt10b	45..389	CDD:381730	135/404 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	171..197		7/44 (16%)
Wnt6	NP_609108.3	Wnt_Wnt6	29..420	CDD:381712	136/407 (33%)