Protein Alignment WNT10B and Wnt4

DIOPT Version :10

• Sequence 1: NP_003385.2
• Gene: WNT10B / 7480
• HGNCID: 12775
• Length: 389
• Species: Homo sapiens
• Sequence 2: NP_476972.2
• Gene: Wnt4 / 34007
• FlyBaseID: FBgn0010453
• Length: 539
• Species: Drosophila melanogaster
• Alignment Length: 347
• Identity: 104/347 - (29%)
• Similarity: 159/347 - (45%)
• Gaps: 65/347 - (18%)

Human    55 SKRQLGLCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAF 119
            ::||...|.:...:..:..:...:|...|:.|.|..|||||....|.|     .|.|:.::|:||
  Fly   246 TRRQNHQCRKETGLPGTLSEARRLATTHCEEQFRYDRWNCSIETRGKR-----NIFKKLYKETAF 305

Human   120 SFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFPHSLPSPGPGS 184
            ..::.||.:.|::|.||:.|::..|.||.|....:
  Fly   306 VHALTAAAMTHSIARACAEGRMTKCSCGPKKHNRE------------------------------ 340

Human   185 SPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKC 249
                 .|| ::|||||.::..|::.:|.|||.|....|..:.:..|::.||.:.|:..:..||||
  Fly   341 -----AQD-FQWGGCNDNLKHGKRVTRSFLDLRGGDGDEVSEILRHDSEVGIEAVSSQMMDKCKC 399

Human   250 HGTSGSCQFKTCWRAAPEFRAVGAALRERLGRAIFIDTHNRN----SGAFQPRLRPRRLSGE--- 307
            ||.||||..||||:...:|.|....||::...||....:.|:    |.:...:.:.||...:
  Fly   400 HGVSGSCSMKTCWKKMADFNATATLLRQKYNEAIRKAPNQRSMRQVSSSRMKKPKQRRKKPQQSQ 464

Human   308 ---LVYFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFH 369
               |.|.|.||.:|        ..|:.|.|...    |.||:||||||:......:||:|.|||:
  Fly   465 YTTLYYLETSPSYC--------AVTKDRQCLHP----DNCGTLCCGRGYTTQVVKQVEKCRCRFN 517

Human   370 --WCCYVLCDECKVTEWVNVCK 389
              .||.::||.|:..|....||
  Fly   518 NGRCCQLICDYCQRLENKYFCK 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WNT10B	NP_003385.2	Wnt_Wnt10b	45..389	CDD:381730	102/345 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	171..197		2/25 (8%)
Wnt4	NP_476972.2	Wnt_Wnt9	245..539	CDD:381715	102/345 (30%)