Protein Alignment WNT10B and Wnt5

DIOPT Version :10

• Sequence 1: NP_003385.2
• Gene: WNT10B / 7480
• HGNCID: 12775
• Length: 389
• Species: Homo sapiens
• Sequence 2: NP_476924.1
• Gene: Wnt5 / 32838
• FlyBaseID: FBgn0010194
• Length: 1004
• Species: Drosophila melanogaster
• Alignment Length: 505
• Identity: 128/505 - (25%)
• Similarity: 178/505 - (35%)
• Gaps: 211/505 - (41%)

Human    48 CLTLSGLSKRQLGLCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGG---GRLPHHSAI 109
            |.:..|||..|...|:::..|..:..:|...|:.|||.|.:::|||||.....   |.:...:|
  Fly   548 CYSAIGLSNSQKKQCVKHTSVMPAISRGARAAIQECQFQFKNRRWNCSTTNDETVFGPMTSLAA- 611

Human   110 LKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFP 174
                 .|.||..::.||.|...:|.||..|:|.||.|                     ||| |.|
  Fly   612 -----PEMAFIHALAAATVTSFIARACRDGQLASCSC---------------------SRG-SRP 649

Human   175 HSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREA-------------------- 219
            ..|             .|.|:||||..:::|..||:.||:||||.
  Fly   650 KQL-------------HDDWKWGGCGDNLEFAYKFATDFIDSREKETNRETRGVKRKREEINKNR 701

Human   220 ----------------------------------------------------------------- 219
                                                                             
  Fly   702 MHSDDTNAFNIGIKRNKNVDAKNDTSLVVRNVRKSTEAENSHILNENFDQHLLELEQRITKEILT 766

Human   220 ------------------------------------------------PRD-------------- 222
                                                            ||:
  Fly   767 SKIDEEEMIKLQEKIKQEIVNTKFFKGEQQPRKKKRKNQRAAADAPAYPRNGIKESYKDGGILPR 831

Human   223 ----IQAR--MRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGR 281
                ::||  |.:|||..||:.|.:..:..|||||.||||...|||:.....|.:|..|||:...
  Fly   832 STATVKARSLMNLHNNEAGRRAVIKKARITCKCHGVSGSCSLITCWQQLSSIREIGDYLREKYEG 896

Human   282 AIFIDTHNRNSGAFQPRLRPRRL------SGELVYFEKSPDFCERDPTMGSPGTRGRACNKTSRL 340
            |..:..:.|.      ||:.:.|      :.:|:|.::|||:|.....:..|||.||.|:|.|..
  Fly   897 ATKVKINKRG------RLQIKDLQFKVPTAHDLIYLDESPDWCRNSYALHWPGTHGRVCHKNSSG 955

Human   341 LDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDEC-KVTEWVNVCK 389
            |:.|..||||||:|.......|||:|:|||||.|.|:.| ||.| .:.||
  Fly   956 LESCAILCCGRGYNTKNIIVNERCNCKFHWCCQVKCEVCTKVLE-EHTCK 1004

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WNT10B	NP_003385.2	Wnt_Wnt10b	45..389	CDD:381730	126/503 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	171..197		5/25 (20%)
Wnt5	NP_476924.1	Wnt_Wnt5	548..1004	CDD:381711	126/503 (25%)