Protein Alignment WNT1 and wntD

DIOPT Version :10

• Sequence 1: NP_005421.1
• Gene: WNT1 / 7471
• HGNCID: 12774
• Length: 370
• Species: Homo sapiens
• Sequence 2: NP_650272.1
• Gene: wntD / 41633
• FlyBaseID: FBgn0038134
• Length: 309
• Species: Drosophila melanogaster
• Alignment Length: 354
• Identity: 90/354 - (25%)
• Similarity: 134/354 - (37%)
• Gaps: 91/354 - (25%)

Human    50 SKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSG-GLQSAVRECKWQFRNRRWNCPTAPGPHLF 113
            :.:|..||||    :|..|.... |.|.....::| ||:.|:..|:..|:.:|||||:.......
  Fly    12 TSTLAAVLEP----MSYYQYTQF-QAPLSWEDITGKGLKQALDSCQQSFQWQRWNCPSQDFVQKN 71

Human   114 GK-IVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNI--- 174
            .| ..|...||..::.||:.|.:.|::.:.|:.|.|..|                 ||::|.
  Fly    72 SKPEENSPNREDVYVAAISMAAIVHTLTKDCANGVIAGC-----------------GCTENALNV 119

Human   175 -----------DFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCH---GMSG 225
                       .:.:.||.   .||..|         ||.......:...:.|||:|.   .:.|
  Fly   120 PCAHEPTKALEQYEKHFGS---GSGAIG---------HNRRVVGALLQRSLEQECRCKQPGAVQG 172

Human   226 SCTVRTCWMRLPTLRAVGDVLRDRFD------GAS---RVLYGNRGSNRASRAELLRLEPEDPAH 281
            .|....|...|....|:...|...:|      |||   ::::.|              .|.|
  Fly   173 ECQEEECVAVLKPFEAIAQDLLQMYDDAIQLEGASSNLKIMWQN--------------IPLD--- 220

Human   282 KPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACN-SSSPALD---GCELLCCGRGHRTRTQRV- 341
                  .||:.:.|||:|.........||.||.|: ..|.:|:   .|:.||...|:|.|:|.|
  Fly   221 ------SLVFMQDSPNYCERDATGLWKGTRGRQCSKDGSGSLEERLSCQQLCRVCGYRVRSQHVR 279

Human   342 TE-RCNCTFHWCCHVSCRNCTHTRVLHEC 369
            || ||||...|...:.|..|......:.|
  Fly   280 TERRCNCKLVWGFRLQCDVCVQLERQYSC 308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WNT1	NP_005421.1	Wnt_Wnt1	64..370	CDD:381707	85/340 (25%)
wntD	NP_650272.1	Wnt_Wnt8	28..309	CDD:381714	83/334 (25%)