Protein Alignment WNT1 and Wnt4

DIOPT Version :10

• Sequence 1: NP_005421.1
• Gene: WNT1 / 7471
• HGNCID: 12774
• Length: 370
• Species: Homo sapiens
• Sequence 2: NP_476972.2
• Gene: Wnt4 / 34007
• FlyBaseID: FBgn0010453
• Length: 539
• Species: Drosophila melanogaster
• Alignment Length: 312
• Identity: 103/312 - (33%)
• Similarity: 163/312 - (52%)
• Gaps: 26/312 - (8%)

Human    65 SRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNC--PTAPGPHLFGKIVNRGCRETAFI 127
            :|:|....|:..|:..::|...:.|...|:.|||..||||  .|....::|.|:.    :||||:
  Fly   246 TRRQNHQCRKETGLPGTLSEARRLATTHCEEQFRYDRWNCSIETRGKRNIFKKLY----KETAFV 306

Human   128 FAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVD-SGEKG 191
            .|:|:|.:|||:||:|:||.:..|:|..::......|:.||||:||:..|:...|.|:| .|..|
  Fly   307 HALTAAAMTHSIARACAEGRMTKCSCGPKKHNREAQDFQWGGCNDNLKHGKRVTRSFLDLRGGDG 371

Human   192 RDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRV 256
            .::..::. |::|.|...|.|:|..:|||||:||||:::|||.::....|...:||.:::.|.|.
  Fly   372 DEVSEILR-HDSEVGIEAVSSQMMDKCKCHGVSGSCSMKTCWKKMADFNATATLLRQKYNEAIRK 435

Human   257 LYGNRGSNRASRAELLRLEPEDPAHKPPSPH--DLVYFEKSPNFCTYSGRLGTAGTAGRACNSSS 319
            ....|...:.|.:.:.:  |:....||....  .|.|.|.||::|        |.|..|.|...
  Fly   436 APNQRSMRQVSSSRMKK--PKQRRKKPQQSQYTTLYYLETSPSYC--------AVTKDRQCLHP- 489

Human   320 PALDGCELLCCGRGHRTRTQRVTERCNCTFH--WCCHVSCRNCTHTRVLHEC 369
               |.|..||||||:.|:..:..|:|.|.|:  .||.:.|..|......:.|
  Fly   490 ---DNCGTLCCGRGYTTQVVKQVEKCRCRFNNGRCCQLICDYCQRLENKYFC 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WNT1	NP_005421.1	Wnt_Wnt1	64..370	CDD:381707	103/312 (33%)
Wnt4	NP_476972.2	Wnt_Wnt9	245..539	CDD:381715	103/312 (33%)