back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NSD2 and NSD

DIOPT Version :9

Sequence 1:	NP_001035889.1	Gene:	NSD2 / 7468	HGNCID:	12766	Length:	1365	Species:	Homo sapiens
Sequence 2:	NP_733239.1	Gene:	NSD / 43351	FlyBaseID:	FBgn0039559	Length:	1427	Species:	Drosophila melanogaster

Alignment Length:	1451	Identity:	392/1451 - (27%)
Similarity:	603/1451 - (41%)	Gaps:	355/1451 - (24%)

- Green bases have known domain annotations that are detailed below.

Human     4 SIKQSPLSVQSV--VKCIKMKQ---------APEILGSANGKTPSCEVNRECSVFLSKAQL--SS 55
            |.:|:|:..|..  |..:..|:         :|:.:|.||..:|:...:.:.::..::.::  ::
  Fly    88 SQRQTPVQKQQQQRVSMVNRKRDLINLQSALSPKYIGYANANSPTPLSDSDDTIRTTRRRVNQAA 152

Human    56 SLQEGVMQKFNGHD-ALPFIPA--------DKLKDLTSRVF----------NG---------EPG 92
            :|......:...|| |.|..|.        |....|.|:.:          ||         |.|
  Fly   153 ALNNSSAGETLAHDNASPRTPGGGGGGGGDDSANQLLSKTYMSPIEKLLIKNGASSPNSTGFEAG 217

Human    93 AHDAKLR-----FESQEMKGIGTPPNTTPI-KNGSPEIKLKITKTYMNGKPLFES---------- 141
            :.|..:|     ...::||.:.....|..: :....|:..|..||    :|:.|.
  Fly   218 SEDLGIRPIVRKHVKRKMKRVPKAKVTLELDEKNQQEVDEKSVKT----EPIDEEVDRTDEAPTQ 278

Human   142 -------SICGD------SAADVSQSEEN------------------GQKPENKARRNRK----- 170
                   ||..:      :|.||...:|:                  .::|::..:...:
  Fly   279 EAQTTAISIKSETEAEHKAAVDVHIKQEDTIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFAL 343

Human   171 ---RSIKYDSLLEQGLVEAALVSKISSPSDKKIPAKK-------ESCPNTGRDKDHLLKYNVGDL 225
               .|.:.|......|...||.:.|.|||...|.:.|       ...|.          |.||||
  Fly   344 PLASSTEVDLKSPPDLSSTALATSIKSPSSVSIDSAKGLSIVTDPGWPT----------YQVGDL 398

Human   226 VWSKVSGYPWWPCMVSADPL--------LHSYTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLV 282
            .|.||..|.:|||||..|||        .|.............|.||:||.|...|.||..::|:
  Fly   399 FWGKVFSYCFWPCMVCPDPLGQIVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLL 463

Human   283 AFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFL 347
            .|.|...|:.:.:|...:...|:.|.:.:.|...|: ..|...|.:|:....:...:|..||...
  Fly   464 TFAGLKAFDDMREELRIKHGPKSAKYRQMVPKRTKV-VIWRQAIEEAQAMTQIPYSDRLEKFYQT 527

Human   348 YVGDQLHLNPQVAKEAGIAAESLGEMAES----------------SGVSEEAAENP--------K 388
            | .:.:.||.|..|......:...::..|                ..|..|.:|:|        |
  Fly   528 Y-ENVVTLNRQKRKRTKYMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESPFSPAFSPVK 591

Human   389 SVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVSM----- 448
            |..|     ||.:|.||.:..|.     |.|.::...|            |.:.:|||..
  Fly   592 SKNE-----KRAKRRKLSNGTEA-----DTGSNSMAVT------------PSQTETTVDSSAYEN 634

Human   449 PRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQ----WSL----LSEKQRARYNTK 505
            |..|:  ..|..:.:...:|          |.|::|::|.|.    |||    |.|.:|.
  Fly   635 PEFRQ--LLSAVMEYVMMNR----------SDEKVEKVLLSVVSNIWSLKQIQLRELERD----- 682

Human   506 FALVAPVQAEEDSGNVNGKKRNHTKRIQDPTEDAEAEDTPRKRLRTDKHSLRKRDTITDKTARTS 570
               :|..:.||..|:                                        ::..:.:...
  Fly   683 ---LASGEIEEPLGS----------------------------------------SVVGRGSGVG 704

Human   571 SYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENEVSDSPGDE 635
            :.|.:  ::.|.:....::::....|      ::|.|        .|.|...|:|...:..|.:.
  Fly   705 TIKRL--SNRLMTMMVRRSMTPVVTP------STTPA--------PSEPDRRLSEPPKTKKPVNR 753

Human   636 PSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGS-LLLCEGPCCGAFHLACL---- 695
            |.|...|..      :.:.||...||::  :|.:|:.|.:.|| |:.|...|....|..||
  Fly   754 PIEEVIEDI------LQLDSKYLFRGLS--REPICKYCYQAGSDLVRCSRTCSSWLHADCLERKV 810

Human   696 -----------------GLSRRP---EGRFT--------------CSECASG-IHSCFVCKE--- 722
                             ..|:.|   |...|              |.||..| ...|.:|.:
  Fly   811 TGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNVGEPEGCVICHQVES 875

Human   723 -------------SKTDVK----RCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHAS 770
                         |.|.::    .|....|||.:|.:|.|.:|.........|||.|.|.:|.:.
  Fly   876 PAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSARCPRHVCHTCVSD 940

Human   771 NPSNPRPSKG--KMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVNVSW 833
            :||......|  |:.:|||||..||....|:.||..::.:.:|||..|..|:.    .|||||.|
  Fly   941 DPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRHNIAKA----DAHVNVLW 1001

Human   834 CFVCSKGGSLLCCESCPAAFHPDCLNIEM-PDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAE 897
            |::|.|||.|:|||:||.|.|..|.||.: .:.|:.|.:|.:|:...:.:|:|.|..|:|||||.
  Fly  1002 CYICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEIVWAKFNNFRWWPAI 1066

Human   898 VCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNAL 962
            :..|..||.||.|..|...:|.|.|||:.|:.|..:.||:.|:|||.|   .|.:...::|:|..
  Fly  1067 ILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTG---DGHKTKSQLFRNYT 1128

Human   963 QEAEARFREIKLQREARETQESERK------PPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPT 1021
            ...|...|.:.:.:..|:.|:.||:      ||||..||.||....:: ::.::.::..|||.|.
  Fly  1129 TGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAVPPLR-FSQNLEDLSTCNCLPV 1192

Human  1022 DENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKG 1086
            ||:|||.::.||||||..||:|:.|.||..|:|:.|.:|:.|..:::..:.:|:|||.:..|..|
  Fly  1193 DEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVG 1257

Human  1087 EFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETL 1151
            :||.|||||:|:..|...|::....:...::|.|.::||.|||||||||.:|||||||:|||||.
  Fly  1258 DFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQ 1322

Human  1152 KWTVNGDTRVGLFAVCDIPAGTELTFNYNL-DCLGNEKTVCRCGASNCSGFLGDRPKTSTTLSSE 1215
            |||||...|||:||:.|||..:||||||.. |.:.|.|..|.|||..|||.:|.:.|       :
  Fly  1323 KWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCSGEIGGKLK-------D 1380

Human  1216 EKGKKTKKKTRRRRAKGEGKR 1236
            :..|...|..:.||||....|
  Fly  1381 DAVKAHAKLKQMRRAKASAVR 1401

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.