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Protein Alignment NSD2 and pps

DIOPT Version :9

Sequence 1:	NP_001035889.1	Gene:	NSD2 / 7468	HGNCID:	12766	Length:	1365	Species:	Homo sapiens
Sequence 2:	NP_001247075.1	Gene:	pps / 41524	FlyBaseID:	FBgn0082831	Length:	2018	Species:	Drosophila melanogaster

Alignment Length:	1591	Identity:	285/1591 - (17%)
Similarity:	466/1591 - (29%)	Gaps:	621/1591 - (39%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEFSIKQSPLSVQSVVKCIK------MKQAPEILGSANGKTPS--CEVNRECSVFLSKA-QLSSS 56
            |..|.:::|...:.|.|.::      ||..|     ....||.  .|:.:...|...|| |:...
  Fly   377 MRHSNRRNPNKRKRVRKVVRQTPSKPMKPLP-----PPPTTPQHFPELKKRKEVLEPKAPQIGQI 436

Human    57 LQEGVMQKFNGHDALPFIPADKLKDLTSRVFNGEPGAHDAKLRFESQEMKGIGTPPNTTP----- 116
            :|               :||.|.......:..|.|.....|:|...|.:.....|..|||
  Fly   437 IQ---------------MPATKSVPAVFALGRGLPSTSFLKIRPTHQSLPVKRPPLPTTPANSNV 486

Human   117 ----------IKNGSPEIK-LKITKTYMNGKPLFE--SSICGDS--------------------- 147
                      |.|...|:| :.|.|...:.|.:|.  :::.|:.
  Fly   487 RRMPAVQLGRIVNSPQEVKEIIINKNMASPKGVFTNLNTLLGEDNNAATKSSPVPLRHRAVMSPS 551

Human   148 -------------------------------AADVSQSE--------ENGQKPENKARRNRKR-- 171
                                           ..|.:||.        |..|.....|..|.|:
  Fly   552 TPRSSYNQQMSPIVVPVPAQAHTPSKGFMPIGVDTAQSHKLPAQIVIETHQSSSELAAENDKQLD 616

Human   172 ---SIKYDSLLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGY 233
               ||..|.||:..|||..:|:     :|:.||...:...:|..|.|
  Fly   617 LINSIVQDELLKSTLVEQPVVN-----ADEDIPKLVKMLESTAADLD------------------ 658

Human   234 PWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPE---RAWIFEKSLVAFEGEGQFEKLCQ 295
               |..||....:....:::|...:|..........|.|   .|...:..:...|.:.|||
  Fly   659 ---PPPVSLPTNIFPAPEMQGVGNAAAADPNNIMDTANEDEITADFLQHVVGLIEEDKQFE---- 716

Human   296 ESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNPQVA 360
                     ||.:|       ::.|..|.|.:.|..:...|:|....              |||.
  Fly   717 ---------AEVVK-------QVLASTEPGTLDAIVSMPTSIEPVDV--------------PQVQ 751

Human   361 KEAGIAAE-SLGEMAES--------SGVSEE-AAENP----KSVRE----------ECIPMKRRR 401
            ....:... ||.|.|:|        |..|.. ||..|    |.||.          |....:.:|
  Fly   752 AHTNLLPNASLTEPAQSMTSLPIACSTPSRSVAASTPPTSAKVVRGYGRVIYLPPIEAPTTRAKR 816

Human   402 RAKL----------CSSAETL---ESHPDIGKSTPQKTA----EADPRRGVGSP----PGRKKTT 445
            ||:.          .|.|..|   ||..|...:.|..|:    ::.|..|...|    |...:.:
  Fly   817 RAQFPSAPGMAATSSSDAGNLSFGESSLDASINQPLNTSSLSNDSQPGSGPKRPNPREPSMARRS 881

Human   446 VSMPRSRKGDAASQFLVFCQKHRDEVVAEHPDAS-GEEIEELLRSQWSLLSEKQRARYNTKFALV 509
            .:..||:|.||:..              ..|||| .:|.::.....|.:.    |..:|.:|.:.
  Fly   882 TAPRRSKKLDASQN--------------NDPDASESQEDDDDPNKLWCIC----RQPHNNRFMIC 928

Human   510 APVQAEEDSGNVNGKKRNHTKRIQDPTEDAEAE-DTPRKRLRTDKHSLRKRDTITDKTARTSSYK 573
            ..:..:...|...|.    ||.:....|:...: ..|:...|.::   |.:..|||......:.:
  Fly   929 CDLCEDWFHGTCVGV----TKAMGTDMENKGIDWKCPKCVKRQEE---RSQPRITDMLVTRPTTQ 986

Human   574 AMEAASSLKSQAATKNLSDACKPLKKRNR---ASTAASSALGFSKSSS----PSASLTENE---- 627
            ..:..|..|....|..:.....|...|..   ..|.|||.:....:..    |:.:::..:
  Fly   987 PEQRPSETKVLTTTAEIVQVAAPSAPRRTLPVVLTVASSPMRIPMAKPAKKFPTGAISHQQQQQL 1051

Human   628 ----VSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCG 688
                :..|||...||:                             :|.:|::|.|
  Fly  1052 NFIRLGPSPGKRISET-----------------------------LCVVCKRPAS---------- 1077

Human   689 AFHLACLGLSRRPEGRFTCSECASGIHSCFVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFE 753
                                  .|.::                   ||    |.|::||
  Fly  1078 ----------------------TSSVY-------------------CG----EECIRKY------ 1091

Human   754 SRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFT 818
                   ..|.:..||:. ..|.|..                     ||...:.:||      |.
  Fly  1092 -------AQSAIQAHAAT-KGPLPQN---------------------AGAQSLLNNS------FD 1121

Human   819 ARKGKRHH---------------AHVNVSWCFVCSKGGSLLCCESCPAAF--------HPDCLNI 860
            |:|.|:..               ..:||    ...|.|.::.....|:|.        :|   :.
  Fly  1122 AKKNKKKDLFEDVLRQADTVSKVERINV----FERKSGRVITGHMAPSAHQFRKWLQENP---SF 1179

Human   861 E-MPDGSWFCNDCRAGKKLHFQDIIWVK--------------LGNYR---WWPAEVCHPKNVPPN 907
            | :|.|:  .....|.|:|       :|              ||..:   ..||::.||:|.  .
  Fly  1180 EVLPSGT--VQSADAEKRL-------LKGAPEAATSTSEPAVLGVAKKPPEGPAKLSHPQNT--T 1233

Human   908 IQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRY-----QGVR-GIGRVFKNALQEAE 966
            :| ..|::|...|.....||     :.:..|.::....:|.     :.|| ||.|..:..|.
  Fly  1234 VQ-ASHQLGISSVRPLAKKD-----KEKTTPTVQAPTPNRIAAGKPEPVRIGIRRSLREQLL--- 1289

Human   967 ARFREIKLQREARETQESERKP----PPYKHIKVNKPYGKVQI-----YTADISEIPKCNCKPTD 1022
            ||.      :||:..:|:..:|    |..  ::|::....|::     :..|:
  Fly  1290 ARI------KEAQAAEENSGQPTTQWPTV--LEVDQFVKNVELEMFNSFGRDV------------ 1334

Human  1023 ENPCGFDSECLNRMLMFE-------------CHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKG 1074
                |...:...|.|||.             |..||.|.    |....|..|....::.|
  Fly  1335 ----GAKYKAKYRSLMFNIKDRKNRTLFEKICAKQVEPR----QLVRMTPEQLASQELAK----- 1386

Human  1075 WGLVAKRD----IRKGEF-----VNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDA 1130
            |.....|.    |:|.|.     ...||.:....||.:|.     :.|:      |:.::.:.:|
  Fly  1387 WREEENRHQLDMIKKSELDLLACAQNYVVKTHKGEEVIAT-----KVDV------TLPEENVSEA 1440

Human  1131 GPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGA 1195
            ....: ::..:...:|:..||                                   |::..|..|
  Fly  1441 SSMAD-TKQTSLVSEPSTSTL-----------------------------------ERSTSREKA 1469

Human  1196 SNCSGFLGDRPKTSTTLSSEEKGKKTKK--KTRRRRAKGEGKRQSEDECFR--CGDGGQLVLCDR 1256
            .                ||:||..|:.|  ..:|.|::...:.:|.|:..|  ..:||:..
  Fly  1470 G----------------SSKEKRHKSHKHHHRKRSRSRSNSRGRSVDKRHRRQHNEGGEQP---- 1514

Human  1257 KFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCK---EHQDGTAFSCTPD 1318
                        |.|:|.....|          |.|.....:.|:...|   |:........|.:
  Fly  1515 ------------GSGEREHRSRE----------KQSRERDEIVPSPLPKKRDENDQSPVPKKTAE 1557

Human  1319 GRSYCCEHDLGAASVRSTKTEKPPPEPGKPK 1349
            .::....::|....:.|.||.:.....||||
  Fly  1558 KKTEASAYNLVDQILESEKTVEQAANLGKPK 1588

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.