Protein Alignment NSD2 and Su(var)3-9

DIOPT Version :10

• Sequence 1: NP_001427822.1
• Gene: NSD2 / 7468
• HGNCID: 12766
• Length: 1398
• Species: Homo sapiens
• Sequence 2: NP_524357.2
• Gene: Su(var)3-9 / 41483
• FlyBaseID: FBgn0263755
• Length: 635
• Species: Drosophila melanogaster
• Alignment Length: 659
• Identity: 143/659 - (21%)
• Similarity: 210/659 - (31%)
• Gaps: 224/659 - (33%)

Human   686 VSSKKSERGVTAKKE-------------YVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGR 737
            :|.||.:..:|:|::             ::.:|........||..|...:...:...:.||...|
  Fly    83 LSEKKIKNLLTSKQQRQQYEIKQRSMLRHLAELRRHSRFRRLCTKPASSSMPASTSSVDRRTTRR 147

Human   738 FTCSEC-----ASGIHSCFVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGF---RCPL 794
            .|....     :||..|.|.|:|...|                   |.|    ...||   :...
  Fly   148 STSQTSLSPSNSSGYGSVFGCEEHDVD-------------------KIP----SLNGFAKLKRRR 189

Human   795 HSCVSCHASNPSN---------PRPSKG----KMMRCVRC----PV------AYHSGD---ACLA 833
            .|||.....|...         .||.||    :.:.||..    ||      .||..:   ..||
  Fly   190 SSCVGAPTPNSKRSKNNMGVIAKRPPKGEYVVERIECVEMDQYQPVFFVKWLGYHDSENTWESLA 254

Human   834 --AGCSVIASNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPA----AFHPDCLN 892
              |.|:.:..        |..|..:.:..::......:..:..:|...|:...    |:.|..|.
  Fly   255 NVADCAEMEK--------FVERHQQLYEIYIAKITTELEKQLEALPLMENITVAEVDAYEPLNLQ 311

Human   893 IEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFG 957
            |::                       :.|..||          ......|:...:|||
  Fly   312 IDL-----------------------ILLAQYR----------AAGSRSQREPQKIGE------- 336

Human   958 SKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARETQESERKPP 1022
                      |....|:..|..           |....|.|:....|       :.....|:..|
  Fly   337 ----------RALKSMQIKRAQ-----------FVRRKQLADLALFE-------KRMNHVEKPSP 373

Human  1023 PYKHIKVNKPYGKVQIYTADIS-----------EIPK-------CNCKPTDENPCGFDSECLNRM 1069
            |   |:|.   ..:.:.|.|.:           ::||       |.| ..|...|...::|..|.
  Fly   374 P---IRVE---NNIDLDTIDSNFMYIHDNIIGKDVPKPEAGIVGCKC-TEDTEECTASTKCCARF 431

Human  1070 --------------------LMFECHPQVCPAGEFCQNQCFTK-RQYPETKIIKTDGKGWGLVAK 1113
                                .::||:.: |.....|.|:.... ||.|.......:|.|||:.|.
  Fly   432 AGELFAYERSTRRLRLRPGSAIYECNSR-CSCDSSCSNRLVQHGRQVPLVLFKTANGSGWGVRAA 495

Human  1114 RDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTI----DKDRIIDAGPKGNYSRFMN 1174
            ..:||||||.||:||:|..:|...|.|...:|..|:.:.|..    |.:..|||...||.|.|:|
  Fly   496 TALRKGEFVCEYIGEIITSDEANERGKAYDDNGRTYLFDLDYNTAQDSEYTIDAANYGNISHFIN 560

Human  1175 HSCQPNCETLK-WTVNGDTRVGL-----FAVCDIPAGTELTFNY-----------NLDCLGNEKT 1222
            |||.||..... |..:  ..|.|     |.:..|.||.||:|:|           ||...  .:.
  Fly   561 HSCDPNLAVFPCWIEH--LNVALPHLVFFTLRPIKAGEELSFDYIRADNEDVPYENLSTA--VRV 621

Human  1223 VCRCGASNC 1231
            .|||||.||
  Fly   622 ECRCGADNC 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD2	NP_001427822.1	None
Su(var)3-9	NP_524357.2	PTZ00327	11..>80	CDD:240362
		Chromo	219..268	CDD:459793	11/56 (20%)
		SET_SUV39H	388..634	CDD:380940	72/249 (29%)