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Protein Alignment NSD2 and ash1

DIOPT Version :9

Sequence 1:	NP_001035889.1	Gene:	NSD2 / 7468	HGNCID:	12766	Length:	1365	Species:	Homo sapiens
Sequence 2:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster

Alignment Length:	1505	Identity:	327/1505 - (21%)
Similarity:	520/1505 - (34%)	Gaps:	467/1505 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    33 GKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGH--DALPFIPADKLKDLTSRVFNGEPGAHD 95
            |:|.:.::..|   .::||:..:.:|..|.:|..|.  ..:|.:||..         |..|..::
  Fly   234 GQTVNAKLAEE---KVAKAKEETLVQTAVPRKRRGRPKKVVPTVPAPG---------NSGPAINE 286

Human    96 AKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQ- 159
            :.   :|..:....|..:|||    ||:::.:      |..|.....|...|...:..:..:.:
  Fly   287 SA---DSGVISTTSTTQSTTP----SPKMQNE------NAVPTGSLPIASSSKPKIDMAYLDKRM 338

Human   160 ---------KPENKARRNRKRSIKYDSLLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKD 215
                     .|.:|.|:|.|::....|..|:..::         |..::|...|         |.
  Fly   339 YATERVLYPPPRSKRRQNNKKTACSSSNKEELQLD---------PLWREIDVNK---------KF 385

Human   216 HLLKYNVG--------DLVWSKV----SGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFG 268
            .|...:||        ..:.|||    |||            :..|..::.| :|:..::..:..
  Fly   386 RLRSMSVGAASGTGASTTICSKVLAAKSGY------------VSDYGSVRHQ-RSSHNHNSGYKS 437

Human   269 DAPERAWIFEKSLVAFEGEGQ---FEKLCQESAKQAPTKAEKIK---LLKPISGKLRAQWEMGIV 327
            ||..::....||.::.....:   :...|:||.|.......|.:   |||
  Fly   438 DASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRASMLLK--------------- 487

Human   328 QAEEAASMSVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSEEAAENP--KSV 390
               .:|..:||::          |.|.|       ||:   |||:.:|.   |.|....|  ||:
  Fly   488 ---SSADDTVEDQ----------DILQL-------AGL---SLGQSSEE---SNEYISKPSLKSL 526

Human   391 REECIPMKRRRRAKLCSSAETL-------ESHPD--IGKSTPQKTAEADPRRGVGSPPGRKKTTV 446
            .......|.....:..::.:..       .::||  |.|...|:.          ..|...|::.
  Fly   527 PTTSASKKYGEINRYVTTGQYFGRGGSLSATNPDNFISKMMNQRK----------ETPAPSKSSC 581

Human   447 SMPRSRKGDAASQFLVFC-------QKHRDEVVAEHPDASGE-----EIEELL------------ 487
            .: :||:..|||....:.       ::||.:..:.:...:.:     |||.:.
  Fly   582 KI-KSRRSSAASMCSSYVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDD 645

Human   488 RSQWSLLSEKQRARYN-TKFALVAPVQAEEDSGNVNGK--------KRNHTKR-IQDPTED---- 538
            |...|...||..|..| .:..|.||..|::.:.|..|.        ||...|| :.:|..|
  Fly   646 RLTGSSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAML 710

Human   539 -AEAEDTP--------------RKRLRTDKHS-------LRKRDTITDKTARTSSYKAM------ 575
             |.|..||              :|....|..|       |:||..:.....|..:..|.
  Fly   711 SASASGTPNGSGSSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLN 775

Human   576 -----EAASSLKSQAATK--------NLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENE 627
                 .||::.||.|:||        ::..|..|.|:.......:.|..|.|.|:||...:.:|.
  Fly   776 AEAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNN 840

Human   628 VSDSPGDEPSESPYESADETQTEVSVSSKKSERG------VTAKKEYVCQLCEKPGSLLLCEGPC 686
             |.|.|.....||....         |.|:..||      |:|.|:.| ||....||.     |.
  Fly   841 -SISGGKLLDISPSSLC---------SLKQQRRGGAAKQKVSAAKDLV-QLQSPAGSY-----PP 889

Human   687 CGAFHLAC-----LGLSRRPEGRFTCSECASGIHSCFVCKE-SKTDV-KRCVVTQCGKFYHEACV 744
            .|.|..:.     :.||:..|...|.:|..|.:.|....|| :|.:| :|.|.|...|......:
  Fly   890 PGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSALDIKEDTKKEVGQRVVETLLHKTGGNLLL 954

Human   745 KK---------YPLTVFESRGFRC--------------------PLHSCVSCHASNPSNPRPSKG 780
            |:         :|....:.|....                    ||.|.....:||..|.:.:..
  Fly   955 KRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAPN 1019

Human   781 KMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHF----TARKGKRHHAHVNVSWCFVCSKGG 841
            ..:.|.|.|.|..:.:..:|.........|::.....    |..:|:              .:|.
  Fly  1020 PPLDCERVPQAGEARETFVARTNQKAPRLSVVALERLQRPQTPARGR--------------PRGR 1070

Human   842 SLLCCESCPAAFHPDCL--------------------------------------NIEMPDG--- 865
            .....|...||..|...                                      ||.:|||
  Fly  1071 KPKNREQAEAAPQPPPKSEPEIRPAKKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDP 1135

Human   866 --SWFC-------NDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEI------ 915
              ::.|       .:..||.:...:.            |.:....:.:||.|...:.||
  Fly  1136 NTNFSCKIRLKRRKNLEAGTQPKKEK------------PVQPVTVEEIPPEIPVSQEEIDAEAEA 1188

Human   916 -----------------GEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRV------ 957
                             ...|    |.:||....::      ..|:.|. ..:|.:.:|
  Fly  1189 KRLDSIPTEHDPLPASESHNP----GPQDYASCSES------SEDKAST-TSLRKLSKVKKTYLV 1242

Human   958 -------FKNALQEAEARFREIKLQREARETQESERKPPPY--KHIKVNK-----PYG------- 1001
                   :|.:|....|:..: |...|.:....|...||||  |:::..:     ||.
  Fly  1243 AGLFSNHYKQSLMPPPAKVNK-KPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTN 1306

Human  1002 -----------------KVQIYTADIS------EIPKCNCKPTDENPCGFDSECLNRMLMFECHP 1043
                             :..:|...:.      :.|.||||...|..| .|: |||||:..||.|
  Fly  1307 SKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHPTCNCKNQGEKSC-LDN-CLNRMVYTECSP 1369

Human  1044 QVCPAGEFCQNQCFTKRQY-PETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIK 1107
            ..|||||.|:||...:... |..:...|..||||:..|..|.||.::.|||||::.|:|...|:.
  Fly  1370 SNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMA 1434

Human  1108 HAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAG 1172
            ..:.|| ||.|.|.:|...:||....|:..||:||||:||||..||:|||.:|:.|||...|..|
  Fly  1435 SIYLND-THHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEG 1498

Human  1173 TELTFNYNLDCLG-NEKTVCRCGASNCSGFLGDRPKTSTTLSSEE-----------KGKKTKKKT 1225
            .|||::||..... :|...|||....|.|.:|.:.:....|.:.|           .|::.|:|.
  Fly  1499 EELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGGKSQRVKPLPAVEAKPSGEGLSGRNGRQRKQKA 1563

Human  1226 RRRRAKGEGK 1235
            ::...:..||
  Fly  1564 KKHAQRQAGK 1573

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.