DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NSD2 and upSET

DIOPT Version :9

Sequence 1:	NP_001035889.1	Gene:	NSD2 / 7468	HGNCID:	12766	Length:	1365	Species:	Homo sapiens
Sequence 2:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster

Alignment Length:	828	Identity:	163/828 - (19%)
Similarity:	272/828 - (32%)	Gaps:	285/828 - (34%)

- Green bases have known domain annotations that are detailed below.

Human     6 KQS--PLSVQSVVKCIKMKQAPEILG------SANGKTPSCEVNRECSVFLSKAQLSSSLQEGVM 62
            |||  ...::::::.|:..:..|..|      |:.||..:.  |...|.  :|...|:|:.|.|.
  Fly  1805 KQSREDRKLEAILRAIEKMEKQEARGKKDTRQSSGGKRQAS--NSPASP--NKRNSSNSISEDVE 1865

Human    63 QKFNGHDALPFIP-ADKLKDLTSRVFNGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKL 126
            ...:.:.|..... .:|.|...||..|              ....|:|:       ..||...:.
  Fly  1866 TPTSTNSAAAAAQRRNKKKRKVSRSLN--------------NNTNGLGS-------GGGSNNKRR 1909

Human   127 KITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDSLLEQGLVEAALVSK 191
            |......:|:         ..|...|:||:.||.|::....:..::        .||: .||...
  Fly  1910 KSIVVESDGE---------SHALTNSESEDQGQHPQSHHSGSEDQA--------AGLL-LALAHN 1956

Human   192 ISSPSDK-KIP-AKKESCPNTGRDKDH---LLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTK 251
            .|||::. |.| ::..|.|.|......   |::..:|.|...        |...||.|.|..:..
  Fly  1957 NSSPNEPFKSPLSQSHSLPATPASVSSACLLIEAAMGPLQQQ--------PAPASASPSLAEFKY 2013

Human   252 LKGQKKSARQYHVQFFGDAPERAWIFEKSLV---AFEGEGQFEKL-CQESAKQAPTKAEKIKLLK 312
            ..|..|:.:.....:|..|.::......|||   ..|..|:.|:| .|...:..|..|    |||
  Fly  2014 PPGGAKTKKSLMSSWFQQAEQQHASGLDSLVQAAMSEINGEREQLQRQPQGESLPAPA----LLK 2074

Human   313 PISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHL----NPQVAK---EAGIAAES- 369
            .         |..|.|||...::...|            ||||    |..|.|   ...|:.|:
  Fly  2075 V---------EQFIHQAESTTAVPARE------------QLHLPLQNNSSVKKRWLRQAISEETT 2118

Human   370 -LGEMAESSGVSEEAAENPKSV-------REECIPMKRRRRAKLC--SSAETLESHPDIGKSTPQ 424
             :.|:.:|...|..|..:|:.|       .....|:|:||...:.  ::.|:.|:|.|:
  Fly  2119 PVDELQQSQNQSVTATPSPQPVPTVSPLANGFSTPLKKRRLVVVSNGTNVESDETHIDV------ 2177

Human   425 KTAEADPRRGVGSPPGRKKTTVSMPRSRKGDAASQFLVFCQKHRDE-----------------VV 472
                      :|.|....:..|:|         ::..|..:.|..|                 :|
  Fly  2178 ----------IGEPKDEAEENVAM---------TELKVEIENHHQEQDDDVDILRSPSPGTHQIV 2223

Human   473 AE------HPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKR 531
            ||      .|:.:....:::     .:..|::.::...||..:..|:.||:.     ::....|:
  Fly  2224 AEDNLVKIEPEDTSAAADDV-----KIDVEREESQACDKFEEMVKVKREEEE-----QREKEIKQ 2278

Human   532 IQD------------PTE--------DAEAEDTPRKRLRTDKHS-----------LRKRDTIT-- 563
            :|:            |.|        .||.:..|.:.:.:.|..           ||...|:|
  Fly  2279 LQERQEHEQPKVEPAPVEPKLENTVAKAEPKVEPSQEIVSKKEPTKVEPKPGESLLRSTATVTAT 2343

Human   564 --------------DKTA--------------------------------------------RTS 570
                          .|.|                                            .|:
  Fly  2344 PTAATIAATTLLDVSKVAFKTRPPLKLEDEPQKKKPKLESILPAPVATVPPVSVPPIPAASNATT 2408

Human   571 SYKAMEAASSLKSQAA---TKNLSD-------------ACKPLKKRNRASTAASSALGFSKSSSP 619
            |.....||:||.:..|   ||||::             ....|:.||:.:|||.:      |:||
  Fly  2409 SAVTNTAAASLTTTTAPSSTKNLTEHDIQERLLSFHAANISYLQSRNKKATAALT------SASP 2467

Human   620 SASLTENEVSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKE 667
            |..  .|..|...|.|..:|..:..::...|..:...|.|:..:..||
  Fly  2468 SQK--SNSSSGGSGTESKKSSKDKDEKRDKEKQLKKSKKEKKKSKDKE 2513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NSD2	NP_001035889.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..170		6/20 (30%)
		MSH6_like	218..337	CDD:99898	29/122 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..455		17/87 (20%)
		HMG-box	458..507	CDD:238037	9/71 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..658		42/248 (17%)
		TNG2	<546..710	CDD:227367	38/209 (18%)
		PHD1_NSD1_2	669..711	CDD:277118
		PHD2_NSD2	716..762	CDD:277121
		PHD3_NSD2	763..816	CDD:277124
		PHD4_NSD2	833..873	CDD:277127
		WHSC1_related	878..972	CDD:99899
		AWS	1012..1062	CDD:197795
		SET	1063..1186	CDD:214614
		S-adenosyl-L-methionine binding. /evidence=ECO:0000269\|PubMed:27571355, ECO:0007744\|PDB:5LSU	1115..1118
		S-adenosyl-L-methionine binding. /evidence=ECO:0000269\|PubMed:27571355, ECO:0007744\|PDB:5LSU	1141..1142
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1207..1232
		PHD5_NSD2	1241..1283	CDD:277130
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1333..1365
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030