Protein Alignment NSD2 and E(z)

DIOPT Version :10

• Sequence 1: NP_001427822.1
• Gene: NSD2 / 7468
• HGNCID: 12766
• Length: 1398
• Species: Homo sapiens
• Sequence 2: NP_001261682.1
• Gene: E(z) / 39203
• FlyBaseID: FBgn0000629
• Length: 765
• Species: Drosophila melanogaster
• Alignment Length: 930
• Identity: 185/930 - (19%)
• Similarity: 306/930 - (32%)
• Gaps: 334/930 - (35%)

Human   421 KSVREECIPMKRRRRAKLCS---------------SAETLESHPDIGKSTPQ--------KTAEA 462
            :.|:.|.|.:::::|.|...               :.:.|.....:.::.|.        |.||.
  Fly    12 RRVKSEYIKIRQQKRYKRADEIKEAWIRNWDEHNHNVQDLYCESKVWQAKPYDPPHVDCVKRAEV 76

Human   463 DPRRGVGSPPGRKKTTV-------SMPRSRKGDAASQ-FLVFCQKHRDEVVA--------EHPDA 511
            ....|:  |.|.:|..:       .:|.........| |:|     .||.|.        |..|.
  Fly    77 TSYNGI--PSGPQKVPICVINAVTPIPTMYTWAPTQQNFMV-----EDETVLHNIPYMGDEVLDK 134

Human   512 SGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPT--EDAEA 574
            .|:.||||:::.                           .|.|:|.|        ||:  :||..
  Fly   135 DGKFIEELIKNY---------------------------DGKVHGDK--------DPSFMDDAIF 164

Human   575 EDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNL-----------SDACK 628
            .:.....:|:....|.:              .|...|:::|::...|:.           :|...
  Fly   165 VELVHALMRSYSKELEE--------------AAPGTATAIKTETLAKSKQGEDDGVVDVDADGES 215

Human   629 PLKKRNRASTAASSALGFSKSSSPSASLTENEVSDSPGDEPSESPYESAD------ETQTEV--- 684
            |:|              ..|:.| ...|||.|..::  :||.|:  |.||      |.:.::
  Fly   216 PMK--------------LEKTDS-KGDLTEVEKKET--EEPLET--EDADVKPDVEEVKDKLPFP 261

Human   685 ------SVSSKKSERGVTAK-KEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSE 742
                  ::|:...::|...: ||...:|.|                       .:.||....|:.
  Fly   262 APIIFQAISANFPDKGTAQELKEKYIELTE-----------------------HQDPERPQECTP 303

Human   743 CASGIHSCFVCKESKTD------VKRCVVTQCGKFYHEACV-------------KKYPLTVFESR 788
            ...||.:..|.:|....      .:||....|  |.|...|             ::||    |.:
  Fly   304 NIDGIKAESVSRERTMHSFHTLFCRRCFKYDC--FLHRHHVQGLQGHAGPNLQKRRYP----ELK 362

Human   789 GFRCPLHSCVSCH----------ASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGC-SVIASN 842
            .|..|..:  ||:          |::...|             |:     |:|..|.. ....||
  Fly   363 PFAEPCSN--SCYMLIDGMKEKLAADSKTP-------------PI-----DSCNEASSEDSNDSN 407

Human   843 SIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRA 907
            |......|.....|.:...||.:   ..::..|::.          ..:||......|...|...
  Fly   408 SQFSNKDFNHENSKDNGLTVNSA---AVAEINSIMA----------GMMNITSTQCVWTGADQAL 459

Human   908 GKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPY 972
            .:.||     .|.|.||    ..:.|  |:   :.|...::.||
  Fly   460 YRVLH-----KVYLKNY----CAIAH--NM---LTKTCRQVYEF--------------------- 489

Human   973 MEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARETQESERKPPPY----KHIKVNKPY 1033
                                  .|:.:|.|....|:::....::.::|...:    :.|::.|..
  Fly   490 ----------------------AQKEDAEFSFEDLRQDFTPPRKKKKKQRLWSLHCRKIQLKKDS 532

Human  1034 GKVQIYTADISEIP------KCNCKPTD---ENPCGFDSECLNR------------------MLM 1071
            ....:|.....:.|      .|:|..|.   |..|...|:|.||                  :.:
  Fly   533 SSNHVYNYTPCDHPGHPCDMNCSCIQTQNFCEKFCNCSSDCQNRFPGCRCKAQCNTKQCPCYLAV 597

Human  1072 FECHP---QVCPAGEF------CQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVG 1127
            .||.|   |.|.|.:|      |:|.|..:..:....:..:|..|||:..|...:|.||::||.|
  Fly   598 RECDPDLCQACGADQFKLTKITCKNVCVQRGLHKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCG 662

Human  1128 ELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDT 1192
            |:|.::|...|.| .::..:..| :..::.|.::||..|||..||.|||..|||......|.||.
  Fly   663 EIISQDEADRRGK-VYDKYMCSF-LFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDH 725

Human  1193 RVGLFAVCDIPAGTELTFNY 1212
            |:|:||...|..|.||.|:|
  Fly   726 RIGIFAKRAIQPGEELFFDY 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD2	NP_001427822.1	None
E(z)	NP_001261682.1	PRC2_HTH_1	151..291	CDD:436286	33/180 (18%)
		SANT	452..492	CDD:238096	13/96 (14%)
		preSET_CXC	579..610	CDD:408079	5/30 (17%)
		SET_EZH2	628..747	CDD:380995	44/120 (37%)