Protein Alignment NSD2 and egg

DIOPT Version :10

• Sequence 1: NP_001427822.1
• Gene: NSD2 / 7468
• HGNCID: 12766
• Length: 1398
• Species: Homo sapiens
• Sequence 2: NP_611966.3
• Gene: egg / 37962
• FlyBaseID: FBgn0086908
• Length: 1262
• Species: Drosophila melanogaster
• Alignment Length: 1446
• Identity: 279/1446 - (19%)
• Similarity: 444/1446 - (30%)
• Gaps: 576/1446 - (39%)

Human    90 EPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQS 154
            |||    ||..||::.||    .||..|.: ||.:   :.....:...|.||.:...||   ::|
  Fly    84 EPG----KLADESEDRKG----ENTKAIAS-SPVL---VAVDSDSSVELIESPVKFSSA---NES 133

Human   155 EENGQKPE--NKARRNRKRSIKYDSLL------------------EQ---GL-VEAALVSKISSP 195
            |::..||:  |:|.......:...|:.                  ||   |: |:..:...||.|
  Fly   134 EKDPPKPDAVNEAAAKEAEEMTDSSISSPTSESFPEKDEKTNKENEQEPPGMEVDQDVEESISRP 198

Human   196 SDK-KVFRRRCVRGHVTLS----SEHGHPMRAPARVLGRAE---KIPAKKESCPNTGRDKDHLLK 252
            ::: |:  ...::||..:|    .||        :::.:.:   ::..:|.:.|....|:.....
  Fly   199 AEEYKI--ENTLKGHKRISLTEIEEH--------KIVDKKDDVLEVELEKGTAPKAAEDEKLNAL 253

Human   253 YNVGDLVWSK-----------------------------VSGYPWWPCMVSADPLLHSYTKLKGQ 288
            .:.||:.:.|                             .|....:.||...|..:..|.:..||
  Fly   254 LSDGDVFYDKECVNCNCTKLHKQYVLANMATLNFYQVLRKSSKQQFLCMGCHDTAMDLYEEYAGQ 318

Human   289 --------KKSARQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAE----KI 341
                    .|...|.|..|               ||.:...:     :|..|| |.|::    |:
  Fly   319 LMAKQPLLLKDFHQDHADF---------------VALDSSDE-----EEEEKQ-PEKSDFSKNKL 362

Human   342 KL--------LKPISGKL----RAQWEMGIVQAE------EAASMSVEERKAKFTFLYVGDQLHL 388
            :|        :|.:..|:    :..|...|:||:      :.|...||..|.:.|    .|::|.
  Fly   363 QLIEDELDDAIKNVLNKVDFTAQLSWSKTILQAKADHLERQFALADVELEKVQTT----ADKMHC 423

Human   389 NPQVAKEAGIAAESLG--EMAESSGVSE-----EAAENPKSVREECIPMKRRRRAKLCS------ 440
              .:.....:|.:.|.  ::..|..|.|     |....|..:.|....:|.:..|...|
  Fly   424 --ALYNSCPVAHKHLPTLDIEPSDYVHEVPPPGEIVRPPIQLGETYYAVKNKAIASWVSIKVIEF 486

Human   441 ------SAETLESHPDIGKSTPQ---KTAEADPRRGVGSPPGR-----------KKTTVSMPRSR 485
                  :..|::|:.....:||.   ||..|........||.|           ..||:|..:.
  Fly   487 TESTAINGNTMKSYKIRYLNTPYQMIKTVTAKHIAYFEPPPVRLTIGTRVIAYFDGTTLSRGKD- 550

Human   486 KGDAASQF-----------------LVFCQ-------KHRD-EVVAEHPDASGEEIEELLRSQWS 525
            ||...|.|                 |:|..       .||| .:|.:..:...|::....|.
  Fly   551 KGVVQSAFYPGIIAEPLKQANRYRYLIFYDDGYTQYVPHRDVRLVCQASEKVWEDVHAASRD--- 612

Human   526 LLSEKQRARYNTKFALVAPVQAEEDSGNVNGK--------------------KRNHTKRIQDPTE 570
             ..:|...:|:....:|...:.:..:...||.                    .:|||:.|.
  Fly   613 -FIQKYVEKYSVDRPMVQCTRGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDKNHTEWIY---- 672

Human   571 DAEAEDTPRKRLRTDKHSLRKRDTITDKTA-------RTSSY----KAMEAASSLKSQA---ATK 621
                    |..||........::.:...:|       ||..:    |.||::|.:..|.   |.|
  Fly   673 --------RGSLRLGPVFRETQNNMNSSSAQQLRVPRRTEPFIRYTKEMESSSKVNQQMRAFARK 729

Human   622 NLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENEVSDSPGDEPSESPYESADETQTEVSV 686
            :.:.|      :|.|..|||||      ::|:...|     ::.|...|.|.........:.:.|
  Fly   730 SSASA------QNNALAAASSA------ATPAGGRT-----NAGGVSTSNSASAVRHLNNSTIYV 777

Human   687 SSKKSERG----VTAK-----KEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSE 742
            ..:...:|    .|||     |.|.|..|          .|.|         |.:......:.|.
  Fly   778 DDENRPKGHVVYFTAKRNLPPKMYKCHEC----------SPNC---------LFKIVHRLDSYSP 823

Human   743 CASGIHSCFVCKESKTDVKRCVVTQ--CGKFYHE-ACVKKY---PLTVFESRGFR-CPLHSCVSC 800
            .|..:.|.:.....:...|:.||.:  |||.... |.|.:|   ...|.....|. .|...|::.
  Fly   824 LAKPLLSGWERLVMRQKTKKSVVYKGPCGKSLRSLAEVHRYLRATENVLNVDNFDFTPDLKCLAE 888

Human   801 HASNPSNPRP---SKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHV 862
            ::.:||..:.   |||:....:.. |.|:  |..|...|:            :..::......|:
  Fly   889 YSIDPSIVKDTDISKGQEKMAIPL-VNYY--DNTLPPPCT------------YAKQRIPTEGVHL 938

Human   863 NVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIW-VKLGNYRW 926
            |:...|       ||||         ||.           :||....|.    ..| :.:...|:
  Fly   939 NLDEEF-------LLCC---------DCE-----------DDCSDKSKC----ACWQLTVAGVRY 972

Human   927 WPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVF 991
                 |:||       |...|||                               ||
  Fly   973 -----CNPK-------KPIEEIG-------------------------------YQ--------- 985

Human   992 KNALQEAEARFREIKLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDE 1056
                                            ||.:..:.|.|   ||..:    .:|.||
  Fly   986 --------------------------------YKRLHEHVPTG---IYECN----SRCKCK---- 1007

Human  1057 NPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEF 1121
                  ..||||::.|....::                    ::.||..:||||....||.||.|
  Fly  1008 ------KNCLNRVVQFSLEMKL--------------------QVFKTSNRGWGLRCVNDIPKGAF 1046

Human  1122 VNEYVGELIDEE--------------------ECMARIKHAHENDITH----------------- 1149
            :..|.|.|:.|.                    |...::|..:|:::.|
  Fly  1047 ICIYAGHLLTETMANEGGQDAGDEYFADLDYIEVAEQLKEGYESEVDHSDPDAEEDNGGPDAEDD 1111

Human  1150 -------FYMLTI------------------------------------------------DKDR 1159
                   .|...|                                                .||.
  Fly  1112 DDFRPNYHYQRKIKRSSRSGSTQNSSTQSSELDSQERAVINFNPNADLDETVRENSVRRLFGKDE 1176

Human  1160 ---IIDAGPKGNYSRFMNHSCQPNCETLKWTVN-GDTR---VGLFAVCDIPAGTELTFNYNLD-- 1215
               |:||...||..|:.||||.||.......|: .|.|   |..|:...|.:|||||:|||.:
  Fly  1177 APYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNYEVG 1241

Human  1216 CLGNEKTVCRCGASNC 1231
            .:..:...|:|||.||
  Fly  1242 VVPGKVLYCQCGAPNC 1257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD2	NP_001427822.1	None
egg	NP_611966.3	Tudor_SETDB1_rpt1	532..622	CDD:410453	16/94 (17%)
		Tudor_SETDB1_rpt2	630..684	CDD:410548	9/65 (14%)
		HMT_MBD	823..879	CDD:238689	13/55 (24%)
		SET_SETDB1	900..1262	CDD:380915	100/525 (19%)