Protein Alignment NSD2 and Set1

DIOPT Version :10

• Sequence 1: NP_001427822.1
• Gene: NSD2 / 7468
• HGNCID: 12766
• Length: 1398
• Species: Homo sapiens
• Sequence 2: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Alignment Length: 1330
• Identity: 261/1330 - (19%)
• Similarity: 422/1330 - (31%)
• Gaps: 403/1330 - (30%)

Human   110 TPPNTTPIKNGSPEIKLKIT-----KTYMNGKPLFESSICGDSAADVSQSEENGQKPE------- 162
            |.||:.|   |:.::..:|.     ||:.|..|..:        .|.|.||.:..|||
  Fly   510 TQPNSDP---GTVDLDTRIALIFKGKTFGNAPPFLQ--------MDSSDSETDQGKPEVFSDVNS 563

Human   163 -NKARRNRKRSIKYDSLLEQGLVEAALVS---KISSPSDKKVFRRRCVR----GHVTLSSEHGHP 219
             :....|:|||.:.::.:.....||:.:|   ::....||......|.:    .:::|||
  Fly   564 DSNNSENKKRSCEKNNKVLHQPNEASDISSDEELIGKKDKSKLSLICEKEVNDDNMSLSS----- 623

Human   220 MRAPARVLGRAEKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWW----PC-----MVSA 275
                   |...|.....||..........::..::..:..:...|||..:    |.     :.|.
  Fly   624 -------LSSQEDPIQTKEGAEYKSIMSSYMYSHSNQNPFYYHASGYGHYLSGIPSESASRLFSN 681

Human   276 DPLLHS-YTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQ------ESAKQ 333
            ...:|| |.|..          ..|..|:..:.:.:.|..::.:.:|..:|:.|      |..||
  Fly   682 GAYVHSEYLKAV----------ASFNFDSFSKPYDYNKGALSDQNDGIRQKVKQVIGYIVEELKQ 736

Human   334 APTKAEKIKLLKPISGK-LRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHL--------- 388
            ...:....::::..:.| ....|:   ....:|.|..:.| ||..|   |...|:.
  Fly   737 ILKRDVNKRMIEITAFKHFETWWD---EHTSKARSKPLFE-KADST---VNTPLNCIKDTSYNEK 794

Human   389 NPQVAKEAGIAAESLGEMAE-----SSGVSEEAAENP--KSVRE--ECIPMKRRRRAKLCSSAET 444
            ||.:    .:...:..|:|:     |.|:.....:.|  :.:|:  ..||.||....:..|..|.
  Fly   795 NPDI----NLLINAHREVADFQSYSSIGLRAAMPKLPSFRRIRKHPSPIPTKRNFLERDLSDQEE 855

Human   445 LESHPDIGKSTPQKTAEADPRRGVGSP-----PGRKKTTVSMPRSRKGDAASQFLVFCQKHRDEV 504
            :....|..|...........|..:..|     ...|..|..:...|||.|:|.|.........|.
  Fly   856 MVQRSDSDKEDSNVEISDTARSKIKGPVPIQESDSKSHTSGLNSKRKGSASSFFSSSSSSTSSEA 920

Human   505 VAEHPDA-----SGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEE-DSGNVNGKKRNHTK 563
            ..|..|.     :.||.......|.:|.......|.......:..:.... .||:...||.|.||
  Fly   921 EYEAIDCVEKARTSEEDSPRGYGQRNLNQRTTTIRNRNLVGTMDVINVRNLCSGSNEFKKENVTK 985

Human   564 RIQDPTEDAEAEDTPRKRLRTDKHSLRKRDTIT-----DKTARTSSYKAME---AASSLKSQAAT 620
            |    |:.....||.....||...:|::::..|     ::.::.|.....|   ..:.|:....|
  Fly   986 R----TKKNIYSDTDEDNDRTLFPALKEKNISTILSDLEEISKDSCIGLDENGIEPTILRKIPNT 1046

Human   621 KNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENEV------SDSP--------GDEPSE 671
            ..|::.|:      |:.|..           |.....|.|:      ...|        .|...|
  Fly  1047 PKLNEECR------RSLTPV-----------PPPGYNEEEIKKKVDCKQKPSFEYDRIYSDSEEE 1094

Human   672 SPYESADETQTE---------VSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLAC 727
            ..|:...:..||         :....|:.|:.:...       .:.|.:::....
  Fly  1095 KEYQERRKRNTEYMAQMEREFLEEQEKRIEKSLDKN-------LQSPNNIVKNNN---------- 1142

Human   728 LGLSRRPEGRFTCSECASGIHSCFVCKESKTDVKRCVVT--------------QCGKFYHEACVK 778
               |.|.:...|.....|...|||   ||.:.|...:|.              :.|......|.|
  Fly  1143 ---SPRNKNDETRKTAISQTRSCF---ESASKVDTTLVNIISVENDINEFGPHEEGDVLTNGCNK 1201

Human   779 KYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIA--- 840
            .|                         :|   ||||..| .:.|| |..|.:..|:..|.:|
  Fly  1202 MY-------------------------TN---SKGKTKR-TQSPV-YSEGGSSQASQASQVALEH 1236

Human   841 ---------------SNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGG------SLLCCESCPA 884
                           |..:..|.:...|:.:      |::.....::.|      ..:|.:....
  Fly  1237 CYSLPPHSVSLGDYPSGKVNETKNILKREAE------NIAIVSQMTRTGPGRPRKDPICIQKKKR 1295

Human   885 AFHPDCLNI---------EMPDGSWFCNDCRAGKKLHF--------------------------- 913
            ...|...|:         |.||        .|.|.:||
  Fly  1296 DLAPRMSNVKSKMTPNGDEWPD--------LAHKNVHFVPCDMYKTRDQNEEMVILYTFLTKGID 1352

Human   914 -QDIIWVK---------------LGNYRW----------WPAEVCHPKNVPPNIQKMK------H 946
             :||.::|               |.|..|          ||         ||:.::.|      |
  Fly  1353 AEDINFIKMSYLDHLHKEPYAMFLNNTHWVDHCTTDRAFWP---------PPSKKRRKDDELIRH 1408

Human   947 EIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREA 1011
            :.|                .||...:.:.|       ||          ::|:.::...|...|.
  Fly  1409 KTG----------------CARTEGFYKLD-------VR----------EKAKHKYHYAKANTED 1440

Human  1012 RETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHP 1076
            ...::...:|....:...||...|:|    .||...:.|.:   .....|.|...:.:|.|
  Fly  1441 SFNEDRSDEPTALTNHHHNKLISKMQ----GISREARSNQR---RLLTAFGSMGESELLKF---- 1494

Human  1077 QVCPAGEFCQNQC-FTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIK 1140
                      ||. |.|:|   .|..|:....|||.|...|...|.|.||||::|.......|..
  Fly  1495 ----------NQLKFRKKQ---LKFAKSAIHDWGLFAMEPIAADEMVIEYVGQMIRPVVADLRET 1546

Human  1141 HAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAG 1205
            ......|...|:..||.:.||||...||.:||:||||.|||.....|:..:.::.:::...|...
  Fly  1547 KYEAIGIGSSYLFRIDMETIIDATKCGNLARFINHSCNPNCYAKVITIESEKKIVIYSKQPIGIN 1611

Human  1206 TELTFNYNLDCLGNEKTVCRCGASNCSGFL 1235
            .|:|::|... |.:||..|.|||..|.|.|
  Fly  1612 EEITYDYKFP-LEDEKIPCLCGAQGCRGTL 1640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD2	NP_001427822.1	None
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:409745
		U2AF_lg	255..>386	CDD:273727
		N-SET	1352..1496	CDD:463344	33/206 (16%)
		SET_SETD1	1490..1637	CDD:380946	53/164 (32%)