Protein Alignment NSD2 and Set2

DIOPT Version :10

• Sequence 1: NP_001427822.1
• Gene: NSD2 / 7468
• HGNCID: 12766
• Length: 1398
• Species: Homo sapiens
• Sequence 2: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Alignment Length: 1636
• Identity: 339/1636 - (20%)
• Similarity: 572/1636 - (34%)
• Gaps: 497/1636 - (30%)

Human     3 FSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNG 67
            |.|::....::..:|  ::|....:..|.:|.:||..              |..::...:|..|.
  Fly   247 FPIQKPKSKLRVSLK--RLKLGGRLESSDSGNSPSSS--------------SPEVEPPALQDENA 295

Human    68 HDALP--------FIPADKLKDLTSRVFNGEPGAHDAKLRFESQEMKGIGTPP------------ 112
            .|..|        .:.|::..|..|::...|......|...|.:|.:.:...|
  Fly   296 MDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQEEGRPVEVEPQDLIDIDMELAK 360

Human   113 -NTTPIKNGSPEIKL-KITKTYMNGKPLFESSICGDSAADVSQSEEN---------GQKPE---- 162
             ..||    .||..| :|....::|.|...      ||.|.::.||:         |::|.
  Fly   361 QEPTP----DPEEDLDEIMVEVLSGPPSLW------SADDEAEEEEDATVQRATPPGKEPAADSC 415

Human   163 NKARRNRKRSIKYDSLLEQGLVEAALVSKISSPSDKKVFRRRCVRGHVTLSSEHGHPMRAPARVL 227
            :.|.|..:||........||.......::|::.|.|::           |.:|..........::
  Fly   416 SSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQI-----------LEAEESQDQEEQHILI 469

Human   228 GRAEKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSA 292
            ...|...::.|...:.....:|::   |.::|..:..      .:..||.:|.|..:...:|
  Fly   470 DLIEDTLSESEVTSSVSPTIEHMV---VEEVVVEENQ------LVDEADEILDSKQEFVIKK--- 522

Human   293 RQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEM 357
                  .|.::...|....|.:  ||.:.:.:..|.|...:.....|.:.:.:.|:..|    |.
  Fly   523 ------VFSESDNIAASLNKDI--FEPKVETKATCGEVVPRPEMVTEDVYITEGIAATL----EK 575

Human   358 GIVQAEEAASMSVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSEEAAENPKS 422
            ..|..:....|..|.:        :.|::.:.|.: |:.....::..|:.|    |:.|...|||
  Fly   576 SAVVTKPTTEMIAETK--------LSDEVVIEPPL-KDESDPKQTEVELPE----SKPAVNIPKS 627

Human   423 VR---------------EECIPMKRRRRAKLC-SSAETLESHPDIGKSTPQKTAEADPRRGVGSP 471
            .|               .||..::......|. :|..|.|...:..::||.||..|..    .||
  Fly   628 ERILSAEVETTSSPLVPPECCTLESVSGPVLLETSLSTEEKSNENVETTPLKTEAAKE----DSP 688

Human   472 PGRKKTTVSMPRSRKGDAASQ--FLVFCQKHRDEVVAEHP-----DASGE------EIEELLRSQ 523
            |       :.|.....:::.:  ||:...:...|.|||..     :..|:      |::|..:..
  Fly   689 P-------AAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPV 746

Human   524 WSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTK-RIQDPTEDAE---AEDTPRKRL-- 582
            ...:|:|::|..|...:..|.|..:..:|.:..|....|| .:.:...|::   |..||.|:.
  Fly   747 AETVSKKEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKES 811

Human   583 -RTDKHSLRKRDTITDKTA-----------------------------RTSSYKAMEAASSLKSQ 617
             ::.|.::.|::|..:|::                             ::|:....|:|.|:.|:
  Fly   812 GKSAKEAILKKETEKEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVISK 876

Human   618 -------------AATKNLSDACKP--LKKRNRASTA-------------ASSAL---------- 644
                         ||.|.|||...|  ||.:.:|.:.             |::.|
  Fly   877 TTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKL 941

Human   645 ----------------------GFSKSSSPSASLTENEV-SDSPGDEPSESPYESADETQTEVS- 685
                                  |..||.|...||..|.| .|||..|.:.||  |:|..|...|
  Fly   942 KKVPTKVEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTVYEDSPNLERNSSP--SSDSAQANTSA 1004

Human   686 --VSSKKSERGVTAKKEYVCQLCE---------KPGSLLLCEGPCCGAFHLACLGLSRRPEGRFT 739
              :...|.::.:..::..:|:..:         .|...:....|...:...:    |:|...:.|
  Fly  1005 GKLKPSKVKKKINPRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSS----SKRNGSKRT 1065

Human   740 CSECASGIHSCFVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRC-------PLHSC 797
            .|:...|         ||.|.:|  .|.|.....|..: ..|||   .|.|..       |||..
  Fly  1066 TSDLDGG---------SKLDQRR--YTICEDRQPETAI-PVPLT---KRRFSMHPKASANPLHDT 1115

Human   798 VSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAG-----CSVIASNSIICTAHFTARKGKR 857
            :...|......:..|..:.|       .:|.|:..:|.     ...:.|..|:..|.......:.
  Fly  1116 LLQTAGKKRGRKEGKESLSR-------QNSLDSSSSASQGAPKKKALKSAEILSAALLETESSES 1173

Human   858 HHAHVNVS-WCFVCSKG-------GSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQ 914
            ..:...:| |....|..       |.:       |.|..|.:|:...|      .....::...|
  Fly  1174 TSSGSKMSRWDVQTSPELEAANPFGDI-------AKFIEDGVNLLKRD------KVDEDQRKEGQ 1225

Human   915 DII-----------WVKLGNYRWWPAEVCHPKNVPPNIQ------------------KMKHEIGE 950
            |.:           ..::.|.. .||....|.....|.:                  :..|.|.:
  Fly  1226 DEVKREADPEEDEFAQRVANME-TPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQ 1289

Human   951 FPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREIK------LQR 1009
            .|                     :|.|.|:.:||..:. :...::.|..|....|:      |:.
  Fly  1290 KP---------------------QGPRASQGRGVASVA-LAPISMDEQLAELANIEAINEQFLRS 1332

Human  1010 EARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPT-DEN-----PCGFDSECLNR 1068
            |...|         ::.:|.|. |...:..:.:.:|: :|:|..| ||.     .||  :.|:||
  Fly  1333 EGLNT---------FQLLKENF-YRCARQVSQENAEM-QCDCFLTGDEEAQGHLSCG--AGCINR 1384

Human  1069 MLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEE 1133
            |||.||.| :|..|..|.|:.|.:.|....::.:|:.||.|:.|:..|..|||:.|||||:||.|
  Fly  1385 MLMIECGP-LCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSE 1448

Human  1134 ECMARIKHAHENDIT-HFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLF 1197
            | ..|.:|.:..|.. |:|.:.:..:.:|||..|||.||::||||.||.||.||||||:.|:|.|
  Fly  1449 E-FERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFF 1512

Human  1198 AVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKT-----------------STTL 1245
            :|..|..|.|:||:|.....|.:...|.|.|:||.|::|..|.:                 ...|
  Fly  1513 SVKPIQPGEEITFDYQYLRYGRDAQRCYCEAANCRGWIGGEPDSDEGEQLDEESDSDAEMDEEEL 1577

Human  1246 SSE-EKGK-------KTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLG 1302
            .:| |:|:       |.|.|.:.:.....|:::.|          |....||::  ||
  Fly  1578 EAEPEEGQPRKSAKAKAKSKLKAKLPLATGRKRKE----------QTKPKDREY--KA------- 1623

Human  1303 LGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGRSYCCEHDLGAASVR 1367
                  |:|.          |||                                      |:..
  Fly  1624 ------GRWL----------KPS--------------------------------------ATGS 1634

Human  1368 STKTEKPPPEP 1378
            |:..||||.:|
  Fly  1635 SSSAEKPPKKP 1645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD2	NP_001427822.1	None
Set2	NP_572888.2	valS	<709..832	CDD:237855	26/122 (21%)
		AWS	1358..1410	CDD:197795	22/55 (40%)
		SET_SETD2	1410..1551	CDD:380949	62/141 (44%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404