Protein Alignment NSD2 and G9a

DIOPT Version :10

• Sequence 1: NP_001427822.1
• Gene: NSD2 / 7468
• HGNCID: 12766
• Length: 1398
• Species: Homo sapiens
• Sequence 2: NP_001259088.1
• Gene: G9a / 30971
• FlyBaseID: FBgn0040372
• Length: 1657
• Species: Drosophila melanogaster
• Alignment Length: 1738
• Identity: 317/1738 - (18%)
• Similarity: 527/1738 - (30%)
• Gaps: 710/1738 - (40%)

Human    22 KQAPEILGSANGKTPSCEVNRECSVFLSKAQ---LSSSLQEGVMQKFNGHDALPFIPADKLKDLT 83
            ||..|:....|||..|..|..|.:....|..   .::|.:....:.|            |.:...
  Fly   127 KQDSEMEKKQNGKATSITVKMESNERAEKHATEIATTSTERWENESF------------KTEQQN 179

Human    84 SRVFNGEPGAHDAKLRFESQEMKGIGTPPNTT--------PIKNGSPEIKLKITKTYMNGKPLFE 140
            .:....|    :..:...:|:::....|..||        |:...|..:||....|        .
  Fly   180 KKAAEKE----EEPILAATQKLEANAEPLTTTRIEVAVASPLVVSSASVKLAADAT--------N 232

Human   141 SSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDSLLEQGLVEAALVSKISSPSDKKVFRRRC 205
            ......||...:.:::|.|......||:|:..                 ..|.:|:
  Fly   233 QMRAATSAGAATLADKNVQVSPGGTRRSRRTP-----------------RPIDTPT--------- 271

Human   206 VRGHVTLSSEHGHPMRAPARVLGRAEKIPAKKESCPNTGRDKDHLLKYNVGD---LVWSKVSGYP 267
                 :::.||   ::...:..|::|:.    ..|      ..||.::.:.|   :|..::...|
  Fly   272 -----SVTDEH---VQVENKKFGKSEQY----TDC------SSHLERFTLDDNTAIVRLQLKSEP 318

Human   268 WWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKL------ 326
            ..|          |.|.|..::.||         .||:|            |.|:..|:
  Fly   319 DKP----------SLTALSPEENSA---------PAPKR------------GRGRARKIRPDAEV 352

Human   327 --------CQES-AKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYV 382
                    |::| .::.|.:..|:. .:||..:..:...:...:.||.....:.:.|.....:.:
  Fly   353 ETSEVILPCEDSLGEKKPGRKRKLP-DEPIDQQQLSDLVVVKTEQEELGDAPLGDVKRMRRSVRL 416

Human   383 GDQLH-------------LNPQVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRR- 433
            |::||             |:||.:.|...|.           |:.|..  |.:|.:|..|.|:|
  Fly   417 GNRLHADGSPWEEVKTEALHPQPSAELSFAE-----------VTSEIL--PLAVLDEKTPPKKRG 468

Human   434 RRAKLCSSAETLESHPDIG----------------------------KSTPQKTAEADPRR---- 466
            |:||  :....|||....|                            |.|| |..|.|..|
  Fly   469 RKAK--TPCVKLESETSCGLPFANGNKKTNSSGGCELQLPKRSKRRIKPTP-KILENDELRCEFE 530

Human   467 ----------------------------GVGSPPGRKKTTVS-------MPRSRKGDAASQFLVF 496
                                        |..|...|:|:..|       .|....|.:|.:..:|
  Fly   531 TKHIERMTQWESAAAVDGDFETPTTGGNGSNSSTSRQKSDKSDGSNFEGGPGHPAGTSAIKKRLF 595

Human   497 CQKHRD------EVVAEHPDASGEEIEELLR----SQWSLLSEKQRARYNTKFALVAPVQAEEDS 551
            .:..||      .::|:.......::|:.|.    |:.:.....:..:.|.|.......|.|:..
  Fly   596 SKSQRDIENYGAAMLAKSKLPPCPDVEQFLNDIKASRINANRSPEERKLNKKQQRKLAKQKEKHL 660

Human   552 GNVNGKKRNHTKRIQDPTEDAEAEDT-----PRKRLRTDKHS--LRKRDTITDKTARTSSYKAME 609
            .:: |.::||    :|...|.::.:|     |..|::..|.|  ||.|:::|         |.:.
  Fly   661 KHL-GLQKNH----RDEPSDNDSSNTDNEFFPTTRVQVGKPSVTLRVRNSVT---------KELP 711

Human   610 AASSLKSQAATKNLSDACKPLKKRNRASTAA--SSALGFSKSSSPSASLTENEVSDSPGDEPSES 672
            ..::|||               :||....||  :..:|    :..:..:||...:..|...|...
  Fly   712 TTATLKS---------------RRNPVVQAAKLTRRIG----ARAAGEVTEAARASVPISTPDAE 757

Human   673 PYESADET-QTEVSVSSKKSERGVTAK-KEYVCQLCEKPGSLLLCEGP----CCGAFH-----LA 726
            ...|.|.: |.:|:.......|..|:: .:::| ||:||........|    ||...|     :.
  Fly   758 QLHSLDTSIQADVTPIRDLDMRPSTSRVSKFIC-LCQKPSQYYARNAPDSSYCCAIDHIDDQKIG 821

Human   727 CLGLSRRPEGRFTCSECASGIHS----------CFVCKESKTDVKRCVVTQC----------GK- 770
            |            |:|.:|.:|:          ..:|.|.|   ||.....|          ||
  Fly   822 C------------CNELSSEVHNLLRPSQRVSYMILCDEHK---KRLQSHNCCAGCGIFCTQGKF 871

Human   771 -------FYHEACVKKYPLTVF--------ESRG--FRCP--LHSCVSCHASNPSNPRPSKGKMM 816
                   |:|..|.:::.|:..        |.:|  |..|  :..|..|....|..   :....|
  Fly   872 VLCKQQHFFHPDCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCPHCGLDTPER---TSTVTM 933

Human   817 RCVRCPV-----------------------------------AYHSGDACLAAGCSVIAS----- 841
            :|...||                                   |.:.|....|...|..:|
  Fly   934 KCQSLPVFLRTQKYKIKPARLTTSSHLTQFGTVENANTPGATARNKGGLSTAVTLSAASSPASKT 998

Human   842 -------------------NSI-------------ICTAHFTARKGK------------------ 856
                               |||             :...|..:..|:
  Fly   999 NGAQRGRAGTSNSNSRHALNSINFAQLIPESVMNVVLRGHVVSASGRVTAEFTPRDMYYAVQNDD 1063

Human   857 ------------------------------RHHAHVNVSWCFVCSKGGS---------------L 876
                                          .|...:.:::..:| ||.|               |
  Fly  1064 LERVAEILAADFNVLTPIREYLNGTCLHLVAHSGTLQMAYLLLC-KGASSPDFVNIVDYELRTAL 1127

Human   877 LCC---ESCPAAFHPDCLN----------IEMPDGSWFCNDCRAGKKLHFQDIIWVKLGN----- 923
            :|.   |.|      |.||          |:.|||.         ..||    |..:|||
  Fly  1128 MCAVMNEKC------DMLNLFLQCGADVAIKGPDGK---------TSLH----IAAQLGNLEATQ 1173

Human   924 -----YR-------------------W----WPAEVCHPKNVPPNIQKMKHEIGEFP-------- 952
                 ||                   |    |.||:.|...|         .:...|
  Fly  1174 LIVDSYRTSRNITSFLSFIDAQDEGGWTAMVWAAELGHTDIV---------RLASLPQAVFLKLI 1229

Human   953 -VFFFGS----KD-------------YYWT--HQARV--------------FPYMEGDR----GS 979
             :|.|.|    :|             .:|:  |...:              ...:|||.    ..
  Fly  1230 NIFLFISFLLNQDADPNICDNDNNTVLHWSTLHNDGLDTITVLLQSGADCNVQNVEGDTPLHIAC 1294

Human   980 RYQGVR--------GIGRVFKNAL----------QEAEA-----------RFREIKLQ------- 1008
            |:...|        |...:.||..          :|:|.           .||.:.|:
  Fly  1295 RHSVTRMCIALIANGADLMIKNKAEQLPFDCIPNEESECGRTVGFNMQMRSFRPLGLRTFVVCAD 1359

Human  1009 ----REARETQ---------ESERKP-----PPYKH----------IKVNKPYGKVQIYTA-DIS 1044
                ||||..|         |:|.:.     |.:::          :::::...:::|.:. |..
  Fly  1360 ASNGREARPIQVVRNELAMSENEDEADSLMWPDFRYVTQCIIQQNSVQIDRRVSQMRICSCLDSC 1424

Human  1045 EIPKCNCKP-------TDENPCGFDSECLNRMLMFECHPQVCPAGEF-CQNQCFTKRQYPETKII 1101
            ...:|.|..       |.|:....|....:..::|||: .||...:. |:|:..........:|:
  Fly  1425 SSDRCQCNGASSQNWYTAESRLNADFNYEDPAVIFECN-DVCGCNQLSCKNRVVQNGTRTPLQIV 1488

Human  1102 KTD--GKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAG 1164
            :.:  .||||:.|..::.||.||..|.||::...|...|...:        |...:|....|||.
  Fly  1489 ECEDQAKGWGVRALANVPKGTFVGSYTGEILTAMEADRRTDDS--------YYFDLDNGHCIDAN 1545

Human  1165 PKGNYSRFMNHSCQPNCETLK-WTVNGDTR---VGLFAVCDIPAGTELTFNY--------NLDCL 1217
            ..||.:||.||||:||...:: :..:.|.|   :..|:..||.||.|:.|:|        :..|:
  Fly  1546 YYGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCV 1610

Human  1218 GNEKTVCRCGASNC-----SGFLGDRPKTSTTLSSEEKGKKTKKKTRR 1260
            |     |||..:.|     |......|..:||....|.|..:...|.:
  Fly  1611 G-----CRCLTTTCKYASQSSSTNASPTNATTAPENETGTLSSTNTEK 1653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD2	NP_001427822.1	None
G9a	NP_001259088.1	PTZ00121	<68..>188	CDD:173412	14/76 (18%)
		EHMT_ZBD	786..933	CDD:411018	33/165 (20%)
		ANKYR	1063..1322	CDD:440430	45/287 (16%)
		ANK repeat	1088..1120	CDD:293786	5/32 (16%)
		ANK repeat	1124..1153	CDD:293786	8/34 (24%)
		ANK repeat	1155..1196	CDD:293786	10/53 (19%)
		ANK repeat	1199..1249	CDD:293786	11/58 (19%)
		ANK repeat	1251..1283	CDD:293786	2/31 (6%)
		ANK repeat	1285..1316	CDD:293786	6/30 (20%)
		SET_EHMT	1391..1622	CDD:380941	61/244 (25%)