Protein Alignment NSD2 and nsd2

DIOPT Version :10

• Sequence 1: NP_001427822.1
• Gene: NSD2 / 7468
• HGNCID: 12766
• Length: 1398
• Species: Homo sapiens
• Sequence 2: XP_002936809.1
• Gene: nsd2 / 100125213
• XenbaseID: XB-GENE-988824
• Length: 1298
• Species: Xenopus tropicalis
• Alignment Length: 1374
• Identity: 911/1374 - (66%)
• Similarity: 1071/1374 - (77%)
• Gaps: 78/1374 - (5%)

Human    21 MKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSR 85
            |||.|.||||...|..:.||:|||||.|.:||:|:||||||:||.||||:|||||.:||||||||
 Frog     1 MKQVPHILGSPAVKPSNPEVSRECSVLLGRAQISASLQEGVIQKLNGHDSLPFIPTEKLKDLTSR 65

Human    86 VFNGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAAD 150
            |||||.||.:||:|||:||::||.|||:|||.|||||||||||||||||||||||||||||
 Frog    66 VFNGESGAQEAKVRFEAQEVQGIETPPSTTPTKNGSPEIKLKITKTYMNGKPLFESSICGD---- 126

Human   151 VSQSEENGQKPENKARRNRKRSIKYDSLLEQGLVEAALVSKISSPSDKKVFRRRCVRGHVTLSSE 215
              :.||..|..:.|::|.|||.|                  |:|.:::|           :.|..
 Frog   127 --RGEEEPQPEQKKSKRGRKRKI------------------ITSEANEK-----------SSSEM 160

Human   216 HGHPMRAPARVLGRAEKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLH 280
            ..|...:..:.:..:|.:..|.:        :|..|||:|||:|||||||||||||||::||:|:
 Frog   161 PSHSESSKMKPVSESEFLEHKNK--------EDFSLKYSVGDVVWSKVSGYPWWPCMVTSDPVLY 217

Human   281 SYTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLK 345
            |:||:|||||:.|||||||||:|||||||.|||:|.|:||.:::.|||||||||||||||.||||
 Frog   218 SHTKVKGQKKNVRQYHVQFFGNAPERAWISEKSMVPFKGENEYDHLCQESAKQAPTKAEKTKLLK 282

Human   346 PISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESS 410
            ||:||:||||::||.||:|...|:.||||.||||:|:.|:..|||:||.|.|:..||
 Frog   283 PITGKIRAQWDIGIEQAKEGILMTPEERKEKFTFIYIKDRPQLNPRVASEVGVPVES-------- 339

Human   411 GVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAE--ADPRRGVGSPPG 473
              ||::.|:|:  :|.....||||.::  :.|.:.|..| ..|:|..|..|  :|| :|:.||..
 Frog   340 --SEKSTESPQ--KEGSSSYKRRRVSR--TPAASKEVDP-ADKTTTAKGPENSSDP-KGMTSPAS 396

Human   474 RKKTTVSMPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTK 538
            :|::....||||||||.:|||||||||:|||:.||||||.|||||||.|||::||.||:||||||
 Frog   397 KKRSGAYTPRSRKGDAVNQFLVFCQKHKDEVINEHPDASDEEIEELLESQWNMLSNKQKARYNTK 461

Human   539 FALVAPVQAEEDSGNVNGKKRNHTKRIQDPTEDAEAEDTPRKRLRTDKHSLRKRDTITDKTARTS 603
            ||::...::|||||:::|.||||.|...:.|||:|.:::||||||  .|:.::|:|.....||
 Frog   462 FAILTSPKSEEDSGSLHGHKRNHLKTTHNQTEDSEIQESPRKRLR--MHNRKQRETCKPPKAR-- 522

Human   604 SYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENEVSDSPGDE 668
                  |::.:|:..|..:|||||||||||||:||..|.||..|||||| |||||||||||.|||
 Frog   523 ------ASAPVKNSPAMFSLSDACKPLKKRNRSSTLGSVALPVSKSSSP-ASLTENEVSDSQGDE 580

Human   669 PSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRR 733
            .||||.|||||:|.|:|:..:||||| ..|||.|||:|||.|.|:||||.||.||||:|:|||.|
 Frog   581 RSESPSESADESQAEISMLHRKSERG-AMKKELVCQVCEKVGDLMLCEGVCCSAFHLSCIGLSTR 644

Human   734 PEGRFTCSECASGIHSCFVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCV 798
            |.|::.|.||.||..|||:||||..|||||:|..|||||||:|::||||.||||||||||||.|.
 Frog   645 PAGKYLCKECTSGARSCFLCKESNRDVKRCIVPHCGKFYHESCLRKYPLAVFESRGFRCPLHRCA 709

Human   799 SCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVN 863
            :|:.|||||||.|||||:||||||:|||..::|:.|||:.:.|.||||::||.|.|.|.||||:|
 Frog   710 TCYFSNPSNPRASKGKMVRCVRCPLAYHGAESCIVAGCTALTSTSIICSSHFAANKAKSHHAHIN 774

Human   864 VSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWP 928
            ||||||||.||||||||||||||||||||||||||||||||||.|||..|.||||||||||||||
 Frog   775 VSWCFVCSNGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRLGKKPRFNDIIWVKLGNYRWWP 839

Human   929 AEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKN 993
            ||||||||||||||||||.||||||||||||||||||||||||||||||||::.|.:.||:||||
 Frog   840 AEVCHPKNVPPNIQKMKHAIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSKHHGGKSIGKVFKN 904

Human   994 ALQEAEARFREIKLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENP 1058
            ||||||.||.||..||||:.|||:|:||||||||||||||||||:|||||||||||||||:.|.|
 Frog   905 ALQEAETRFCEIMRQREAKVTQENEKKPPPYKHIKVNKPYGKVQVYTADISEIPKCNCKPSSEKP 969

Human  1059 CGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVN 1123
            |||||||||||||:||||||||||:.||||||.||||||||||||:||||||:|.|||:||||||
 Frog   970 CGFDSECLNRMLMYECHPQVCPAGDRCQNQCFNKRQYPETKIIKTEGKGWGLIATRDIKKGEFVN 1034

Human  1124 EYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTV 1188
            ||:||||||||||.||:||.|||||||||||||||||||||||||:||||||||||||||.||:|
 Frog  1035 EYIGELIDEEECMYRIRHAQENDITHFYMLTIDKDRIIDAGPKGNFSRFMNHSCQPNCETQKWSV 1099

Human  1189 NGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSTTLSSEEKGKK 1253
            |||||||||||.|||||.||||||||||||||||:|||||.|||||||||||.:|..|.|||.||
 Frog  1100 NGDTRVGLFAVRDIPAGEELTFNYNLDCLGNEKTICRCGAPNCSGFLGDRPKNNTASSHEEKVKK 1164

Human  1254 TKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHC 1318
            .|||.::||.|.:||:||||.||||.|||:||||||||||||||||||.|.||||||||||||||
 Frog  1165 PKKKQKKRRTKTDGKKQSEDYCFRCNDGGELVLCDRKFCTKAYHLSCLSLTKRPFGKWECPWHHC 1229

Human  1319 DVCGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGRSYCCEHDLGAASVRSTKTEKPPPEPGKPKG 1383
            |||||.|.|.|.||||||||.|.|.:.|:.|.:|:..|.||| ...||.....:..|    |.|.
 Frog  1230 DVCGKASVSCCSLCPNSFCKGHYDDSQFTRTAEGQLCCPEHD-PEESVECEVVKNLP----KKKA 1289

Human  1384 KRRRRRGWR 1392
            |:|:.:..|
 Frog  1290 KQRKNKKTR 1298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD2	NP_001427822.1	None
nsd2	XP_002936809.1	PWWP_NSD2_rpt1	190..317	CDD:438990	93/126 (74%)
		HMG-box_NSD2	408..469	CDD:438807	45/60 (75%)
		TNG2	<484..654	CDD:227367	104/181 (57%)
		PHD1_NSD1_2	613..655	CDD:277118	27/41 (66%)
		PHD2_NSD2	660..706	CDD:277121	35/45 (78%)
		PHD3_NSD2	707..760	CDD:277124	32/52 (62%)
		PHD4_NSD2	777..817	CDD:277127	38/39 (97%)
		PWWP_NSD2_rpt2	823..918	CDD:438993	82/94 (87%)
		AWS	967..1004	CDD:465559	31/36 (86%)
		SET_NSD2	1006..1147	CDD:380988	125/140 (89%)
		PHD5_NSD2	1185..1227	CDD:277130	36/41 (88%)
		C5HCH	1226..1273	CDD:465605	29/47 (62%)