back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NSD2 and nsd2

DIOPT Version :9

Sequence 1:	NP_001035889.1	Gene:	NSD2 / 7468	HGNCID:	12766	Length:	1365	Species:	Homo sapiens
Sequence 2:	XP_002936809.1	Gene:	nsd2 / 100125213	XenbaseID:	XB-GENE-988824	Length:	1298	Species:	Xenopus tropicalis

Alignment Length:	1351	Identity:	910/1351 - (67%)
Similarity:	1067/1351 - (78%)	Gaps:	65/1351 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    21 MKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSR 85
            |||.|.||||...|..:.||:|||||.|.:||:|:||||||:||.||||:|||||.:||||||||
Frog     1 MKQVPHILGSPAVKPSNPEVSRECSVLLGRAQISASLQEGVIQKLNGHDSLPFIPTEKLKDLTSR 65

Human    86 VFNGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAAD 150
            |||||.||.:||:|||:||::||.|||:|||.|||||||||||||||||||||||||||||
Frog    66 VFNGESGAQEAKVRFEAQEVQGIETPPSTTPTKNGSPEIKLKITKTYMNGKPLFESSICGD---- 126

Human   151 VSQSEENGQKPENKARRNRKRSIKYDSLLEQGLVEAALVSKISSPSDKKIPAKKESC---PNTGR 212
              :.||..|..:.|::|.|||.|              :.|:.:..|..::|:..||.   |.:..
Frog   127 --RGEEEPQPEQKKSKRGRKRKI--------------ITSEANEKSSSEMPSHSESSKMKPVSES 175

Human   213 D-------KDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDA 270
            :       :|..|||:|||:|||||||||||||||::||:|:|:||:|||||:.|||||||||:|
Frog   176 EFLEHKNKEDFSLKYSVGDVVWSKVSGYPWWPCMVTSDPVLYSHTKVKGQKKNVRQYHVQFFGNA 240

Human   271 PERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASM 335
            ||||||.|||:|.|:||.:::.|||||||||||||||.||||||:||:||||::||.||:|...|
Frog   241 PERAWISEKSMVPFKGENEYDHLCQESAKQAPTKAEKTKLLKPITGKIRAQWDIGIEQAKEGILM 305

Human   336 SVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRR 400
            :.||||.||||:|:.|:..|||:||.|.|:..||          ||::.|:|:  :|.....|||
Frog   306 TPEERKEKFTFIYIKDRPQLNPRVASEVGVPVES----------SEKSTESPQ--KEGSSSYKRR 358

Human   401 RRAKLCSSAETLESHPDIGKSTPQKTAE--ADPRRGVGSPPGRKKTTVSMPRSRKGDAASQFLVF 463
            |.::  :.|.:.|..| ..|:|..|..|  :|| :|:.||..:|::....||||||||.:|||||
Frog   359 RVSR--TPAASKEVDP-ADKTTTAKGPENSSDP-KGMTSPASKKRSGAYTPRSRKGDAVNQFLVF 419

Human   464 CQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNH 528
            ||||:|||:.||||||.|||||||.|||::||.||:||||||||::...::|||||:::|.||||
Frog   420 CQKHKDEVINEHPDASDEEIEELLESQWNMLSNKQKARYNTKFAILTSPKSEEDSGSLHGHKRNH 484

Human   529 TKRIQDPTEDAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDA 593
            .|...:.|||:|.:::||||||  .|:.::|:|.....||        |::.:|:..|..:||||
Frog   485 LKTTHNQTEDSEIQESPRKRLR--MHNRKQRETCKPPKAR--------ASAPVKNSPAMFSLSDA 539

Human   594 CKPLKKRNRASTAASSALGFSKSSSPSASLTENEVSDSPGDEPSESPYESADETQTEVSVSSKKS 658
            |||||||||:||..|.||..|||||| |||||||||||.|||.||||.|||||:|.|:|:..:||
Frog   540 CKPLKKRNRSSTLGSVALPVSKSSSP-ASLTENEVSDSQGDERSESPSESADESQAEISMLHRKS 603

Human   659 ERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKES 723
            ||| ..|||.|||:|||.|.|:||||.||.||||:|:|||.||.|::.|.||.||..|||:||||
Frog   604 ERG-AMKKELVCQVCEKVGDLMLCEGVCCSAFHLSCIGLSTRPAGKYLCKECTSGARSCFLCKES 667

Human   724 KTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRC 788
            ..|||||:|..|||||||:|::||||.||||||||||||.|.:|:.|||||||.|||||:|||||
Frog   668 NRDVKRCIVPHCGKFYHESCLRKYPLAVFESRGFRCPLHRCATCYFSNPSNPRASKGKMVRCVRC 732

Human   789 PVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAF 853
            |:|||..::|:.|||:.:.|.||||::||.|.|.|.||||:|||||||||.||||||||||||||
Frog   733 PLAYHGAESCIVAGCTALTSTSIICSSHFAANKAKSHHAHINVSWCFVCSNGGSLLCCESCPAAF 797

Human   854 HPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEF 918
            ||||||||||||||||||||.|||..|.||||||||||||||||||||||||||||||||.||||
Frog   798 HPDCLNIEMPDGSWFCNDCRLGKKPRFNDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHAIGEF 862

Human   919 PVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARETQE 983
            ||||||||||||||||||||||||||||::.|.:.||:||||||||||.||.||..||||:.|||
Frog   863 PVFFFGSKDYYWTHQARVFPYMEGDRGSKHHGGKSIGKVFKNALQEAETRFCEIMRQREAKVTQE 927

Human   984 SERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPA 1048
            :|:||||||||||||||||||:|||||||||||||||:.|.||||||||||||||:|||||||||
Frog   928 NEKKPPPYKHIKVNKPYGKVQVYTADISEIPKCNCKPSSEKPCGFDSECLNRMLMYECHPQVCPA 992

Human  1049 GEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHEND 1113
            |:.||||||.||||||||||||:||||||:|.|||:||||||||:||||||||||.||:||.|||
Frog   993 GDRCQNQCFNKRQYPETKIIKTEGKGWGLIATRDIKKGEFVNEYIGELIDEEECMYRIRHAQEND 1057

Human  1114 ITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFN 1178
            ||||||||||||||||||||||:||||||||||||||.||:||||||||||||.|||||.|||||
Frog  1058 ITHFYMLTIDKDRIIDAGPKGNFSRFMNHSCQPNCETQKWSVNGDTRVGLFAVRDIPAGEELTFN 1122

Human  1179 YNLDCLGNEKTVCRCGASNCSGFLGDRPKTSTTLSSEEKGKKTKKKTRRRRAKGEGKRQSEDECF 1243
            |||||||||||:|||||.|||||||||||.:|..|.|||.||.|||.::||.|.:||:||||.||
Frog  1123 YNLDCLGNEKTICRCGAPNCSGFLGDRPKNNTASSHEEKVKKPKKKQKKRRTKTDGKKQSEDYCF 1187

Human  1244 RCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQ 1308
            ||.|||:||||||||||||||||||.|.|||||||||||||||||||.|.|.|.||||||||.|.
Frog  1188 RCNDGGELVLCDRKFCTKAYHLSCLSLTKRPFGKWECPWHHCDVCGKASVSCCSLCPNSFCKGHY 1252

Human  1309 DGTAFSCTPDGRSYCCEHDLGAASVRSTKTEKPPPEPGKPKGKRRRRRGWR 1359
            |.:.|:.|.:|:..|.||| ...||.....:..|    |.|.|:|:.:..|
Frog  1253 DDSQFTRTAEGQLCCPEHD-PEESVECEVVKNLP----KKKAKQRKNKKTR 1298

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.