Protein Alignment WFS1 and wfs1b

DIOPT Version :10

• Sequence 1: NP_005996.2
• Gene: WFS1 / 7466
• HGNCID: 12762
• Length: 890
• Species: Homo sapiens
• Sequence 2: XP_684510.3
• Gene: wfs1b / 556580
• ZFINID: ZDB-GENE-050809-19
• Length: 895
• Species: Danio rerio
• Alignment Length: 889
• Identity: 496/889 - (55%)
• Similarity: 645/889 - (72%)
• Gaps: 42/889 - (4%)

Human     3 SNTAPLGPSCPQPPPAPQPQ-ARSRLNATASLEQERSERPRAPGPQAGPGPGVRDAAAPAEPQAQ 66
            |:|....||...|||....| .||:|||.:      :.....||..|.|            ||.:
Zfish    34 SSTPSPAPSAMTPPPHHASQMGRSQLNAAS------NSSTAFPGQSAFP------------PQGE 80

Human    67 HTRSRERADGTGPTKGDMEIPFEEVLERAKAGDPKAQTEVGKHYLQLAGDTDEELNSCTAVDWLV 131
               |:|            |:..:::.:|||.||.|||||:|::||:||...|||:|:.|||.||:
Zfish    81 ---SKE------------ELSIDDLKQRAKNGDAKAQTEIGRYYLRLAEQEDEEVNAVTAVTWLL 130

Human   132 LAAKQGRREAVKLLRRCLADRRGITSENEREVRQLSSETDLERAVRKAALVMYWKLNPKKKKQVA 196
            .|||.||::|||||:|||.||||||:||..||..|:.|:..:|:||||||:|||||||.:||.:.
Zfish   131 QAAKNGRKDAVKLLQRCLHDRRGITAENREEVCSLACESRFQRSVRKAALLMYWKLNPDRKKNIT 195

Human   197 VAELLENVGQVNEHDGGAQPGPVPKSLQKQRRMLERLVSSESKNYIALDDFVEITKKYAKGVIPS 261
            .:||||||.|:|  ..||...|:...:||||::||.|||.:..:.|.:::|||.||:||:|:.||
Zfish   196 ASELLENVSQLN--TDGASRSPLSSPIQKQRKILESLVSRDETDCIGVEEFVENTKQYAEGISPS 258

Human   262 SLFLQ-DDEDDDELAGKSPEDLPLRLKVVKYPLHAIMEIKEYLIDMASRAGMHWLSTIIPTHHIN 325
            ...:. ||:||||...|.|::|||..||:|:||||::|:||.|||.||||||.|:|.:|||||:|
Zfish   259 MEGVAGDDDDDDEEPVKHPDELPLHQKVLKFPLHAVLEVKEVLIDWASRAGMQWISALIPTHHVN 323

Human   326 ALIFFFIVSNLTIDFFAFFIPLVIFYLSFISMVICTLKVFQDSKAWENFRTLTDLLLRFEPNLDV 390
            .||||||:||||::||...|||:||||||:|||||||:|||:||||||||.||.:|..|||.:|:
Zfish   324 TLIFFFIISNLTLEFFVLVIPLIIFYLSFVSMVICTLRVFQNSKAWENFRALTVMLSHFEPGIDL 388

Human   391 EQAEVNFGWNHLEPYAHFLLSVFFVIFSFPIASKDCIPCSELAVITGFFTVTSYLSLSTHAEPYT 455
            ||||.||.|||||||.:||||..|:|||||:|.|..:||||||::..||||:|||||...|:.:.
Zfish   389 EQAESNFTWNHLEPYLYFLLSTLFLIFSFPVADKSWLPCSELAMVAVFFTVSSYLSLRPTAQQHA 453

Human   456 RRALATEVTAGLLSLLPSMPLNWPYLKVLGQTFITVPVGHLVVLNVSVPCLLYVYLLYLFFRMAQ 520
            :.||.::|.:.:.:.:..:...| ..:::|..:.::.:|..:|::|.|||:||:|||:|..|||.
Zfish   454 KFALLSQVASAIFTFINRLLGGW-VGRIIGGAWFSMRLGDWLVMHVGVPCVLYLYLLFLCTRMAT 517

Human   521 LRNFKGTYCYLVPYLVCFMWCELSVVILLESTGLGLLRASIGYFLFLFALPILVAGLALVGVLQF 585
            ....:||||.|:|.||||:|||:.|.:|.|||.|||:|:.:||.||.||||:|...||.|.::|.
Zfish   518 AGGARGTYCVLLPNLVCFIWCEVCVTLLQESTVLGLMRSVVGYLLFFFALPVLSLALAAVMLVQL 582

Human   586 ARWFTSLELTKIAVTVAVCSVPLLLRWWTKASFSVVGMVKSLTRSSMVKLILVWLTAIVLFCWFY 650
            .:||.:|||||:.|||.:|.:|:||||||:.|.|.:.:::||.|||:|||||||::|:|||.|||
Zfish   583 VQWFLALELTKMIVTVCICVLPVLLRWWTRFSVSPLAVLRSLRRSSVVKLILVWISALVLFSWFY 647

Human   651 VYRSEGMKVYNSTLTWQQYGALCGPRAWKETNMARTQILCSHLEGHRVTWTGRFKYVRVTDIDNS 715
            |||||||||||||||||:|..|||||||||.|||..||:|||||||||||.|||||||||:|:|.
Zfish   648 VYRSEGMKVYNSTLTWQEYSDLCGPRAWKERNMAHAQIICSHLEGHRVTWEGRFKYVRVTEIENG 712

Human   716 AESAINMLPFFIGDWMRCLYGEAYPACSPGNTSTAEEELCRLKLLAKHPCHIKKFDRYKFEITVG 780
            |::.:|:||..|.||:||||||.||||....|..| |.||:||.||||.||:|:||.||||:|:|
Zfish   713 AQAVVNLLPVLIADWVRCLYGEEYPACDENQTGPA-EPLCQLKTLAKHKCHVKRFDHYKFEVTMG 776

Human   781 MPFSSGADGSRSREEDDVTKDIVLRASSEFKSVLLSLRQGSLIEFSTILEGRLGSKWPVFELKAI 845
            || ..|.:|  :::.||.|||||||||:||:.|||.|..||::||||:||||||||||||||||:
Zfish   777 MP-QKGRNG--AQDFDDGTKDIVLRASNEFRRVLLVLSSGSVVEFSTVLEGRLGSKWPVFELKAL 838

Human   846 SCLNCMAQLSPTRRHVKIEHDWRSTVHGAVKFAFDFFFFPFLSA 889
            :|..|.:.|.|.||.||||.|||.....|:.|||:|.|.|.|||
Zfish   839 NCKTCASPLIPIRRQVKIEQDWRVNARNALAFAFNFVFHPLLSA 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WFS1	NP_005996.2	Interaction with ATP6V1A. /evidence=ECO:0000269|PubMed:23035048	1..321		151/319 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..86		21/83 (25%)
		WSLR	99..133	CDD:466262	20/33 (61%)
		WSLR	137..175	CDD:466262	22/37 (59%)
		WEF-hand	176..255	CDD:466231	41/78 (53%)
		WC-rich	666..769	CDD:466275	69/102 (68%)
		WCOB	770..876	CDD:437745	65/105 (62%)
wfs1b	XP_684510.3	None