Protein Alignment WFS1 and wfs1

DIOPT Version :10

• Sequence 1: NP_005996.2
• Gene: WFS1 / 7466
• HGNCID: 12762
• Length: 890
• Species: Homo sapiens
• Sequence 2: NP_651079.2
• Gene: wfs1 / 42679
• FlyBaseID: FBgn0039003
• Length: 853
• Species: Drosophila melanogaster
• Alignment Length: 861
• Identity: 215/861 - (24%)
• Similarity: 365/861 - (42%)
• Gaps: 185/861 - (21%)

Human    95 AKAGDPKAQTEVGKHYLQLAGDTDEELN------SCTAVDWLVLAAKQGRREAVKLLRRCLADRR 153
            |:.|.|:.|.::.|   :|..::..|.|      |..||:|||.||..|..:||||||:|..|..
  Fly    34 AEEGCPQMQYDLAK---ELLDNSIVEPNLAKGNQSQKAVNWLVSAAHNGHEDAVKLLRQCYNDGS 95

Human   154 GITSENEREVRQLSSETDLERAVRKAALVMYWKLNPKKKKQVAVAELLENVGQVNEHDGGAQPGP 218
            |||:||..|||:..:.|..|||.||||                 .||...:...|||       .
  Fly    96 GITAENTDEVRRCLAMTPGERAARKAA-----------------RELFACLSNGNEH-------I 136

Human   219 VPKSLQ-KQRRM--LER--------------------------------LVSSESKNYIALDDFV 248
            .||.|: |.||:  |:|                                |.:.|.:..|.....|
  Fly   137 TPKQLERKMRRIYNLQRKRRRRDDDRSSSSSEGEQEPECEPLEDVPTIDLANVERRRLITEAHLV 201

Human   249 EITKKYAKGVIPS-----SLFLQDDEDDDELAGKSPEDLPLRLKVVKYPL-------HAIMEI-- 299
            .....|:.|.:||     :|.:.|.        :|.:.:|...:::.:||       |.::.:
  Fly   202 SAASNYSAGQMPSVNDALTLSVPDP--------RSLDHVPCFYRMIFHPLIFFTLFYHRLLNLIV 258

Human   300 -KEYLIDMASR----AGMHWLSTIIPTHHINALIFFFIVSNLTIDFFAFFIPLVIFYLSFISMVI 359
             ...:|.::.|    ..:.|.|    :.|:                    :|||.:|||...|:.
  Fly   259 SIPNVIPLSVRCSVLVAISWWS----SRHM--------------------LPLVSYYLSLGIMIW 299

Human   360 CTLKVFQDSKAWENFRTLTDLLLRF-EPNLDVEQAEVNFGWNHLEPYAHFLLSVFFVIFSFPIAS 423
            .|.|:.:..:.:.:||..:.|.|.: :.|::.:.||..|..|:::||.:|..:....:..:|:.:
  Fly   300 ATCKMLKTKQQFVDFRIWSGLFLSYGDQNIEADIAEHRFLRNNMKPYLYFFCAFICNLIVYPLVT 364

Human   424 KDCIPCSELAVITG---FFTVTSYLSLSTHAEPYTRRALATEVTAGLLSLLP-----SMPLNWPY 480
            ...:|.|||.:|:|   |.|:...:..|:|..|  ...:.......:|:..|     .:...|.:
  Fly   365 DAWLPHSELTIISGALTFITMCVSMYASSHQLP--DWLVIVSFAVNVLAKYPYEMDEVVSTRWRF 427

Human   481 LKVLGQTFITVPVGHLVVLNVSVPCLLYVYLLYLFFRMAQLRNFKGTYCYLVPYLVCFMWCELSV 545
            |.:...||.:..:|:.:...::....||:::..|...||:...:.|.|.:|:|:.|...|.::.:
  Fly   428 LDLRVPTFSSFVIGNGIEFCLNCRTALYLFIPVLLIMMAKRSRWHGVYTFLIPHCVTLSWLQVCI 492

Human   546 VILLESTGLGLLRASIGYFLFLFALPILVAGLALVGVLQFARWFTSLELTKIAVTVAVCSVPLL- 609
            .....||..|::||::|                |.|::.|...|..:.|. :.|.||:.|:.|.
  Fly   493 ATSQSSTVFGVMRAALG----------------LAGIVLFLPLFGIVALL-VPVFVAIDSLGLAS 540

Human   610 --LRWWTKA----SFSVVGMVKSLTRS-----SMVKLILVWLTAIVLFCWFYVYRSEGMKVYN-- 661
              |||.:.|    ...|:..:.:|.|:     :|::||....||.:|...:.....:....:|
  Fly   541 EQLRWGSTALACGLVVVLSCILALNRATQKYITMLQLITAITTACLLVLPYMTSSFKDTPRFNAM 605

Human   662 -----------STLTWQQYGALCGPRAWKETNMARTQILCSHLEGHRVTWTGRFKYVRVTDIDNS 715
                       :||.|.::.|||.....::.|..:.|:.||.|.|..|.|.|....|.::.:.|.
  Fly   606 PRAGLHSLSETNTLPWDRFHALCAQPVHEQPNKIKAQLRCSLLNGMPVIWEGSVTKVEISRVSNF 670

Human   716 AESAI-NMLPFFIGDWMRCLYGE---AYPACSPGNTSTAEEELCRLKLL--AKHPCHIKKFDRYK 774
            .|..| |.||.::|..:|||:||   .:..|.|...:..||.....|..  ....|.:::::||:
  Fly   671 LEDTIANYLPVWLGRMLRCLHGENISQHFKCDPKLDAQCEEWRSVFKTFNAQSGSCTLQRWNRYE 735

Human   775 FEITVGMPFS-SGADGSRSREEDDVTKDIVLRASSEFKSVLLSLRQGSLIEFSTIL-EGRLGSKW 837
            :|:.|.:... ||....||     .|.|::|||..:|.:....|.:|.::.|..|| ..||.:..
  Fly   736 YELLVKVGTKRSGRLLGRS-----TTTDVILRAHHDFGNFTRLLSEGDVVLFYGILHNSRLLADN 795

Human   838 PVFELKAISCLNCMAQ 853
            ...:||.|.|:.|.::
  Fly   796 VQVKLKTIECVECRSR 811

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WFS1	NP_005996.2	Interaction with ATP6V1A. /evidence=ECO:0000269|PubMed:23035048	1..321		73/285 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..86
		WSLR	99..133	CDD:466262	12/39 (31%)
		WSLR	137..175	CDD:466262	19/37 (51%)
		WEF-hand	176..255	CDD:466231	21/113 (19%)
		WC-rich	666..769	CDD:466275	32/108 (30%)
		WCOB	770..876	CDD:437745	26/86 (30%)
wfs1	NP_651079.2	TPR	<34..121	CDD:440553	38/89 (43%)
		WSLR	79..117	CDD:466262	19/37 (51%)
		WEF-hand	118..208	CDD:466231	21/113 (19%)
		WC-rich	621..730	CDD:466275	32/108 (30%)
		WCOB	731..853	CDD:437745	26/86 (30%)