Protein Alignment WFS1 and Wfs1

DIOPT Version :10

• Sequence 1: NP_005996.2
• Gene: WFS1 / 7466
• HGNCID: 12762
• Length: 890
• Species: Homo sapiens
• Sequence 2: NP_035846.1
• Gene: Wfs1 / 22393
• MGIID: 1328355
• Length: 890
• Species: Mus musculus
• Alignment Length: 893
• Identity: 776/893 - (86%)
• Similarity: 831/893 - (93%)
• Gaps: 6/893 - (0%)

Human     1 MDSNTAPLGPSCPQPPPAPQPQARSRLNATASLEQERSERPRAPGPQAGPGPG--VRDAAAPAEP 63
            |:|.|.|..||.|.||||||||||:||||||||||::.|.||||.|||.|..|  ..:|||| ||
Mouse     1 MNSGTPPPSPSGPPPPPAPQPQARARLNATASLEQDKIEPPRAPRPQADPSAGRSAGEAAAP-EP 64

Human    64 QAQHTRSRERADGTGPTKGDMEIPFEEVLERAKAGDPKAQTEVGKHYLQLAGDTDEELNSCTAVD 128
            :|..|.|||..|..||.|.|:|||||||||:|||||||||||||||||:||.|.|||||||:||.
Mouse    65 RAPQTGSREETDRAGPMKADVEIPFEEVLEKAKAGDPKAQTEVGKHYLRLANDADEELNSCSAVA 129

Human   129 WLVLAAKQGRREAVKLLRRCLADRRGITSENEREVRQLSSETDLERAVRKAALVMYWKLNPKKKK 193
            ||:|||||||||||||||||||||:|||||||.||:|||||||||||||||||||||||||||||
Mouse   130 WLILAAKQGRREAVKLLRRCLADRKGITSENEAEVKQLSSETDLERAVRKAALVMYWKLNPKKKK 194

Human   194 QVAVAELLENVGQVNEHDGGAQPGPVPKSLQKQRRMLERLVSSESKNYIALDDFVEITKKYAKGV 258
            ||||:|||||||||||.|||||||||||||||||||||||||||||||||||||||:|||||||:
Mouse   195 QVAVSELLENVGQVNEQDGGAQPGPVPKSLQKQRRMLERLVSSESKNYIALDDFVELTKKYAKGI 259

Human   259 IPSSLFLQD-DEDDDELAGKSPEDLPLRLKVVKYPLHAIMEIKEYLIDMASRAGMHWLSTIIPTH 322
            ||::||||| |||:||||||||||||||.|||||||||||||||||||:||:|||||||||:|||
Mouse   260 IPTNLFLQDEDEDEDELAGKSPEDLPLRQKVVKYPLHAIMEIKEYLIDVASKAGMHWLSTIVPTH 324

Human   323 HINALIFFFIVSNLTIDFFAFFIPLVIFYLSFISMVICTLKVFQDSKAWENFRTLTDLLLRFEPN 387
            ||||||||||:|||||||||||||||:|||||:||||||||||||||||||||||||||||||||
Mouse   325 HINALIFFFIISNLTIDFFAFFIPLVVFYLSFVSMVICTLKVFQDSKAWENFRTLTDLLLRFEPN 389

Human   388 LDVEQAEVNFGWNHLEPYAHFLLSVFFVIFSFPIASKDCIPCSELAVITGFFTVTSYLSLSTHAE 452
            ||||||||||||||||||.||||||.|||||||:||||||||||||||:.|||||||:|||:.||
Mouse   390 LDVEQAEVNFGWNHLEPYIHFLLSVVFVIFSFPLASKDCIPCSELAVISTFFTVTSYMSLSSSAE 454

Human   453 PYTRRALATEVTAGLLSLLPSMPLNWPYLKVLGQTFITVPVGHLVVLNVSVPCLLYVYLLYLFFR 517
            |||||||.|||.||||||||::|::|.:||||||||.||||||.::||||:||||||||.|||||
Mouse   455 PYTRRALVTEVAAGLLSLLPTVPVDWRFLKVLGQTFFTVPVGHFIILNVSLPCLLYVYLFYLFFR 519

Human   518 MAQLRNFKGTYCYLVPYLVCFMWCELSVVILLESTGLGLLRASIGYFLFLFALPILVAGLALVGV 582
            ||||||||||||||||||||||||||||||||:||||||:||||||||||||||||||||||:|.
Mouse   520 MAQLRNFKGTYCYLVPYLVCFMWCELSVVILLQSTGLGLVRASIGYFLFLFALPILVAGLALMGT 584

Human   583 LQFARWFTSLELTKIAVTVAVCSVPLLLRWWTKASFSVVGMVKSLTRSSMVKLILVWLTAIVLFC 647
            :||||||.||:||||.||..:|.||||.||||||:|||:|||||||:||||||||||||||:|||
Mouse   585 VQFARWFLSLDLTKIMVTTVICGVPLLFRWWTKANFSVMGMVKSLTKSSMVKLILVWLTAILLFC 649

Human   648 WFYVYRSEGMKVYNSTLTWQQYGALCGPRAWKETNMARTQILCSHLEGHRVTWTGRFKYVRVTDI 712
            |||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||:|
Mouse   650 WFYVYRSEGMKVYNSTLTWQQYGFLCGPRAWKETNMARTQILCSHLEGHRVTWTGRFKYVRVTEI 714

Human   713 DNSAESAINMLPFFIGDWMRCLYGEAYPACSPGNTSTAEEELCRLKLLAKHPCHIKKFDRYKFEI 777
            ||||||||||||||:|||||||||||||:||.||||||||||||||.||||||||||||||||||
Mouse   715 DNSAESAINMLPFFLGDWMRCLYGEAYPSCSSGNTSTAEEELCRLKQLAKHPCHIKKFDRYKFEI 779

Human   778 TVGMPFSSGADGSRSREEDDVTKDIVLRASSEFKSVLLSLRQGSLIEFSTILEGRLGSKWPVFEL 842
            ||||||  |.:|:|..||||:|||||||||||||.|||:||||||||||||||||||||||||||
Mouse   780 TVGMPF--GTNGNRGHEEDDITKDIVLRASSEFKDVLLNLRQGSLIEFSTILEGRLGSKWPVFEL 842

Human   843 KAISCLNCMAQLSPTRRHVKIEHDWRSTVHGAVKFAFDFFFFPFLSAA 890
            |||||||||.||||.|||||||.|||||||||:|||||||||||||||
Mouse   843 KAISCLNCMTQLSPARRHVKIEQDWRSTVHGALKFAFDFFFFPFLSAA 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WFS1	NP_005996.2	Interaction with ATP6V1A. /evidence=ECO:0000269|PubMed:23035048	1..321		267/322 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..86		53/86 (62%)
		WSLR	99..133	CDD:466262	27/33 (82%)
		WSLR	137..175	CDD:466262	34/37 (92%)
		WEF-hand	176..255	CDD:466231	75/78 (96%)
		WC-rich	666..769	CDD:466275	96/102 (94%)
		WCOB	770..876	CDD:437745	92/105 (88%)
Wfs1	NP_035846.1	Interaction with ATP6V1A. /evidence=ECO:0000250|UniProtKB:O76024	1..323		267/322 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..83		51/82 (62%)
		WSLR	100..134	CDD:466262	27/33 (82%)
		WSLR	138..176	CDD:466262	34/37 (92%)
		WEF-hand	177..256	CDD:466231	75/78 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	208..227		17/18 (94%)
		WC-rich	668..771	CDD:466275	96/102 (94%)
		WCOB	772..876	CDD:437745	92/105 (88%)