Protein Alignment WFS1 and wfs1

DIOPT Version :10

• Sequence 1: NP_005996.2
• Gene: WFS1 / 7466
• HGNCID: 12762
• Length: 890
• Species: Homo sapiens
• Sequence 2: NP_001106459.1
• Gene: wfs1 / 100127642
• XenbaseID: XB-GENE-978820
• Length: 863
• Species: Xenopus tropicalis
• Alignment Length: 883
• Identity: 650/883 - (73%)
• Similarity: 748/883 - (84%)
• Gaps: 31/883 - (3%)

Human    14 QPPPAPQPQARSRLNATASLEQERSERPRAPGPQ----AGP---GPGVRDAAAPAEPQAQHTRSR 71
            :|...|....||:|||....|.:  |.|...||.    |.|   .|...|.....:||
 Frog     4 EPSTPPHLLGRSQLNAATFAEGQ--EDPHTSGPSMSGAASPRVFSPVTDDVNDELDPQ------- 59

Human    72 ERADGTGPTKGDMEIPFEEVLERAKAGDPKAQTEVGKHYLQLAGDTDEELNSCTAVDWLVLAAKQ 136
                         |..|:|:||||||||.|||:|||||||:||.:.|||:|||.|||||:.:|||
 Frog    60 -------------EAVFQELLERAKAGDAKAQSEVGKHYLKLAEEQDEEVNSCAAVDWLIASAKQ 111

Human   137 GRREAVKLLRRCLADRRGITSENEREVRQLSSETDLERAVRKAALVMYWKLNPKKKKQVAVAELL 201
            |||:||||||||||||||||:|||.||::||||||||||||||||||||||||||||||:|:|||
 Frog   112 GRRDAVKLLRRCLADRRGITTENESEVKKLSSETDLERAVRKAALVMYWKLNPKKKKQVSVSELL 176

Human   202 ENVGQVNEHDGGAQPGPVPKSLQKQRRMLERLVSSESKNYIALDDFVEITKKYAKGVIPSSLFLQ 266
            |||||||..||..:|||:||:.|||||:||||||||||::||||||||||||||||::||:|.:.
 Frog   177 ENVGQVNAEDGNNEPGPIPKAAQKQRRILERLVSSESKSFIALDDFVEITKKYAKGIVPSNLIIH 241

Human   267 DDEDDDELAGKSPEDLPLRLKVVKYPLHAIMEIKEYLIDMASRAGMHWLSTIIPTHHINALIFFF 331
            ||| |||.|||.||:|||:.|::|||||.|.|:||||||:||:||||||||||||||||||||||
 Frog   242 DDE-DDEFAGKGPEELPLQQKIMKYPLHVITELKEYLIDVASKAGMHWLSTIIPTHHINALIFFF 305

Human   332 IVSNLTIDFFAFFIPLVIFYLSFISMVICTLKVFQDSKAWENFRTLTDLLLRFEPNLDVEQAEVN 396
            |:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   306 IISNLTIDFFAFFIPLVIFYLSFISMVICTLKVFQDSKAWENFRTLTDLLLRFEPNLDVEQAEVN 370

Human   397 FGWNHLEPYAHFLLSVFFVIFSFPIASKDCIPCSELAVITGFFTVTSYLSLSTHAEPYTRRALAT 461
            |||||:|||.:||:|||||||||||..::.|||||||.|:.|||:||||||||.|||||||||.|
 Frog   371 FGWNHMEPYLYFLISVFFVIFSFPITDRNWIPCSELATISIFFTITSYLSLSTSAEPYTRRALMT 435

Human   462 EVTAGLLSLLPSMPLNWPYLKVLGQTFITVPVGHLVVLNVSVPCLLYVYLLYLFFRMAQLRNFKG 526
            ||.||.||||..:|::.|||.:..:||.||||||.::.::||||||:::|.|||||||:||||||
 Frog   436 EVAAGALSLLDHLPISLPYLNIFSKTFFTVPVGHFIIFHISVPCLLFLHLFYLFFRMAKLRNFKG 500

Human   527 TYCYLVPYLVCFMWCELSVVILLESTGLGLLRASIGYFLFLFALPILVAGLALVGVLQFARWFTS 591
            .||||||||||||||||||||:.|||.:||:|||:||||||||||||:.|:.::.::.|.:||.|
 Frog   501 VYCYLVPYLVCFMWCELSVVIIRESTTIGLIRASVGYFLFLFALPILIVGIVVMCIVHFIKWFIS 565

Human   592 LELTKIAVTVAVCSVPLLLRWWTKASFSVVGMVKSLTRSSMVKLILVWLTAIVLFCWFYVYRSEG 656
            ||||||.||:.:|::|:|||||:||::|.|.||||||:||:|||||||:|||::|||.|||||||
 Frog   566 LELTKIVVTLILCTIPVLLRWWSKANYSAVNMVKSLTKSSIVKLILVWITAIMMFCWVYVYRSEG 630

Human   657 MKVYNSTLTWQQYGALCGPRAWKETNMARTQILCSHLEGHRVTWTGRFKYVRVTDIDNSAESAIN 721
            ||||||||||.|||.:||||||||||||||||||||||||||||||||||||:|:||||||||||
 Frog   631 MKVYNSTLTWHQYGFICGPRAWKETNMARTQILCSHLEGHRVTWTGRFKYVRLTEIDNSAESAIN 695

Human   722 MLPFFIGDWMRCLYGEAYPACSPGNTSTAEEELCRLKLLAKHPCHIKKFDRYKFEITVGMPFSSG 786
            |||..||:|||||||||||||.|.|.:..||||||||.|:||.||:|:|||||||||||||| :|
 Frog   696 MLPLLIGNWMRCLYGEAYPACEPQNVTMEEEELCRLKFLSKHSCHMKRFDRYKFEITVGMPF-NG 759

Human   787 ADGSRSREEDDVTKDIVLRASSEFKSVLLSLRQGSLIEFSTILEGRLGSKWPVFELKAISCLNCM 851
            .:.|:..||||:|||||||||:|||.|||:|||||:|||||||||||||||||||||||||||||
 Frog   760 VNASKPIEEDDITKDIVLRASNEFKQVLLNLRQGSIIEFSTILEGRLGSKWPVFELKAISCLNCM 824

Human   852 AQLSPTRRHVKIEHDWRSTVHGAVKFAFDFFFFPFLSA 889
            |:|:|..||||||.|||..||.|:||||||||.|||||
 Frog   825 AKLTPASRHVKIEQDWRRDVHTALKFAFDFFFSPFLSA 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WFS1	NP_005996.2	Interaction with ATP6V1A. /evidence=ECO:0000269|PubMed:23035048	1..321		201/313 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..86		18/78 (23%)
		WSLR	99..133	CDD:466262	24/33 (73%)
		WSLR	137..175	CDD:466262	32/37 (86%)
		WEF-hand	176..255	CDD:466231	65/78 (83%)
		WC-rich	666..769	CDD:466275	84/102 (82%)
		WCOB	770..876	CDD:437745	84/105 (80%)
wfs1	NP_001106459.1	WSLR	74..108	CDD:466262	24/33 (73%)
		WSLR	112..150	CDD:466262	32/37 (86%)
		WEF-hand	151..230	CDD:466231	65/78 (83%)
		WC-rich	640..743	CDD:466275	84/102 (82%)
		WCOB	744..849	CDD:437745	84/105 (80%)