Protein Alignment CLIP2 and DCTN1-p150

DIOPT Version :9

• Sequence 1: NP_003379.4
• Gene: CLIP2 / 7461
• HGNCID: 2586
• Length: 1046
• Species: Homo sapiens
• Sequence 2: NP_524061.1
• Gene: DCTN1-p150 / 39536
• FlyBaseID: FBgn0001108
• Length: 1265
• Species: Drosophila melanogaster
• Alignment Length: 983
• Identity: 225/983 - (22%)
• Similarity: 395/983 - (40%)
• Gaps: 249/983 - (25%)

Human   216 EKDLRLGDRV-LVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLF 279
            ||:|::|.|| |.|....|.|.|||.|.||.|:|.||.||||.|||.|::.|.:||||....|:|
  Fly     3 EKNLKVGARVELTGKDLLGTVAYVGMTSFAVGKWVGVVLDEPKGKNSGSIKGQQYFQCDENCGMF 67

Human   280 A-PIHKVIRIGFPST----------SPAKAKKTK-RMAMGVSALTHSPSS---------SSISSV 323
            . |....:....|.:          :|..|:.|| |::...::|:.|..|         :|:|..
  Fly    68 VRPTQLRLLEAAPGSRRSIEDVSGATPTAAQPTKARLSSSRTSLSSSRQSLLGSRTQLTTSLSER 132

Human   324 SSVASSVGGR-------------PSRS------------GLLTETSSRYARKISGTTALQEALKE 363
            ::.:||:|.|             ||.|            |..:..||:.|..:.  |...|.||
  Fly   133 TASSSSIGPRKSLAPQNSKDKESPSTSLAEGAPAASGGNGAASHASSKRASFVE--TGFLEILK- 194

Human   364 KQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQH-----EQYVAEAEEKL----QRARL 419
                 .|....:.|........::  ...|.::|||:||.     :..:|:..|||    ||...
  Fly   195 -----PQFTPSQPLRSPSFTMPSN--SGAEDKVALLEAQKTSAELQAQLADLTEKLETLKQRRNE 252

Human   420 LVESVR---KEKVDLSNQLEEERRKVEDLQFRVEEESI-----TKGDLETQTQ--LEHARIGELE 474
            ..|.:|   |.|:.. .||:|.|.|:...|..:::|.:     .|..:|.:.|  .|.|.:.:..
  Fly   253 DKERLREFDKMKIQF-EQLQEFRTKIMGAQASLQKELLRAKQEAKDAIEAKEQHAQEMADLADNV 316

Human   475 QSLLLEKAQAERLLRELADN-RLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPD 538
            :.:.|:|..||    |.||. :|...:.|.|:.:||.:|.|.|.|::...:..:.:.....|.|.
  Fly   317 EMITLDKEMAE----EKADTLQLELESSKERIEELEVDLELLRSEMQNKAESAIGNISGGGDSPG 377

Human   539 AA---------EILRLRERL-----LSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYA 589
            .:         :.:||:|.|     |||..:|..:      |..|.|:..::||.:|....||.:
  Fly   378 LSTYEFKQLEQQNIRLKETLVRLRDLSAHDKHDIQ------KLSKELEMKRSEVTELERTKEKLS 436

Human   590 QEV-----------------AGLKDKVQQATSENMGLMDNWK------SKLDSLASDHQKSLE-- 629
            .::                 .|.::.|:|...:.|.|.|..|      ::|::|...|::.:|
  Fly   437 AKIDELEAIVADLQEQVDAALGAEEMVEQLAEKKMELEDKVKLLEEEIAQLEALEEVHEQLVESN 501

Human   630 -----DLKATLNSGPGAQQKEIGELKAVMEGIKMEHQL-----ELGNLQAKHDLETAMHVKEKEA 684
                 ||:..|:...||:::.:.|..|.:|.|....|.     ||  :|..:|..|.:..:....
  Fly   502 HELELDLREELDLANGAKKEVLRERDAAIETIYDRDQTIVKFREL--VQKLNDQLTELRDRNSSN 564

Human   685 LREKLQEA-----------QEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKL 738
            .:|.||:.           ::..|..:.:.|| ::||..|  :||.:|.:.   .::....:.:.
  Fly   565 EKESLQDPSLKMVTETIDYKQMFAESKAYTRA-IDVQLRQ--IELSQANEH---VQMLTAFMPES 623

Human   739 DVEYRGQAQAIEFL--------KEQISLAEKKMLDYERLQRAEAQGKQEVE--------SLREKL 787
            .:...|...:|..:        |..|.:::.:    ||....:|..::.|.        :.:.:|
  Fly   624 FMSRGGDHDSILVILLISRIVFKCDIVVSQTR----ERFPPVDAITREAVTQGHAVQQYAFKCRL 684

Human   788 LVAENRLQA-----VEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTE 847
            |...:.||.     :..|.|.|...::.:.....|.:..::.|:|:.:.|.....:..:.|...|
  Fly   685 LHYVHSLQCALHQILYGLNSCQPDTLLRAGSSLPEMVAQEKIVDGIIELLKSNQLDENSTTDNIE 749

Human   848 MLRAQVSALESKCKSGEKKVDALLKEKR-------RLEAELETVSRKTHDASGQLVLISQELLRK 905
            ...|..:|:.|...:||:    ||.|.:       .|.|..|::...|..|         :::.:
  Fly   750 KCVAFFNAMNSVLLAGEQ----LLNEIQMIRDCVASLGAACESILSDTAIA---------KVIIQ 801

Human   906 ERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQR 970
            |.......|||:                          |.|.:::..:|:::. |.|.:..|||.
  Fly   802 EAGATSDSVLLI--------------------------QFLNENMESVRQQVK-LIKRRLPSDQH 839

Human   971 RYSLIDRSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKA-----QTIGNSGSA 1030
                :.:|...     ||::    :|:|..   ||.:.::|.||.....::     .||.:..:|
  Fly   840 ----VIKSGLS-----QHKV----EAMRGL---AQNISRIMSAMHQATKQSLAAIVSTIESDNAA 888

Human  1031 NGIHQQDK 1038
            .....|:|
  Fly   889 EHTLPQEK 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIP2	NP_003379.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71
		CAP_GLY	81..145	CDD:366568
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	143..162
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	195..215
		CAP_GLY	221..285	CDD:366568	33/65 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..339		11/59 (19%)
		Smc	<357..971	CDD:224117	151/721 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1018..1046		5/26 (19%)
DCTN1-p150	NP_524061.1	CAP_GLY	8..74	CDD:214997	33/65 (51%)
		Dynactin	553..834	CDD:289240	56/330 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1398
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840