DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLIP2 and CLIP-190

DIOPT Version :9

Sequence 1:	NP_003379.4	Gene:	CLIP2 / 7461	HGNCID:	2586	Length:	1046	Species:	Homo sapiens
Sequence 2:	NP_001368962.1	Gene:	CLIP-190 / 35042	FlyBaseID:	FBgn0020503	Length:	1795	Species:	Drosophila melanogaster

Alignment Length:	1315	Identity:	320/1315 - (24%)
Similarity:	546/1315 - (41%)	Gaps:	382/1315 - (29%)

- Green bases have known domain annotations that are detailed below.

Human     3 KPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAAPEKPGPK 67
            :||.:|.|...|         ||||.         ||.|.|....:: |.|.|     |.:....
  Fly    52 QPSKMKAPSSFG---------STGSV---------SKIGRPCCNHTT-PKSGP-----PPREATS 92

Human    68 AAEVGDDFLG-------------------DFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVL 113
            .:...||.|.                   .|::|:|||:.|.:||.:.::|:|.||.|:||||||
  Fly    93 MSRESDDNLSSINSAYTDNSSAVLTANTEQFIIGQRVWLGGTRPGQIAFIGDTHFAAGEWAGVVL 157

Human   114 DDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATP 178
            |:|.|||||.|.|.|||:|...:|||:|.::||..|.|                      |..||
  Fly   158 DEPNGKNDGCVSGKRYFQCEPKRGIFSRLTRLTTYPLA----------------------GAQTP 200

Human   179 --------PLTSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLVG---GTKT 232
                    |..||.:....|:.:|.:::....|.|            .:.:||||:|.   |::.
  Fly   201 TSPLAKSSPDRSRTVSPTASIRSSMLRSPGIGGKN------------GMAVGDRVIVSSGFGSRP 253

Human   233 GVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAK 297
            |::||:|||.||.|.|||||||||.|||||.|...|||:|.||:|:|.||.||      |.||:
  Fly   254 GILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKV------SLSPS- 311

Human   298 AKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTT----ALQ 358
            :|||:     :|......|.:||.:::|:|::...| .|.......||...:.|..|.    ::|
  Fly   312 SKKTR-----LSRTGSRESLTSIGTMNSIATTATSR-MRMNAQQRKSSTPVKPILATPKSQFSMQ 370

Human   359 EALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEI--------------------------- 396
            :.|:|||||:|:|:.||||:|.:   |.:...:::|.|
  Fly   371 DLLREKQQHVEKLMVERDLDRED---AQNQALQLQKNINEVIIFTDTMYAPLPYADRSRPYRPSK 432

Human   397 -ALLKAQHEQYV-------------------------------------------AEAEEKLQRA 417
             :.:|...:|::                                           ....:|.|:|
  Fly   433 KSRVKVPQQQHIWVPTTLSSSITTSTSTRPTIAAATAAAAAAAACNRQPLQQQQQPHLHQKQQQA 497

Human   418 R-LLVESVRKEK--------VDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGEL 473
            : ..|....|:|        |:|.:.|:.||:|.|:||..::|......:|..|:|:...:|.:|
  Fly   498 KPKKVWFCDKKKLFPLKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIHDL 562

Human   474 EQSLLLEKAQAERLLRELADNRLTT--VAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDH 536
            | |.:.:...|...|:.:....|.:  .|.:..:.:|:|::|:::.|:|.
  Fly   563 E-SKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEVES--------------- 611

Human   537 PDAAEILRLRERLLSASKEHQRESGVLRDKY---EKALKAY----------QAEVDKLRAANEKY 588
             ..||.|...:||....|....:...|:.:.   ::||:.:          :.|::.|:..|||.
  Fly   612 -RIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKQ 675

Human   589 AQEV-AGLKDKVQQATSENMGL---MDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGEL 649
            |||. |....|:.:.:.|.:.|   :.|.|:..|||.|:.....::.: .|.:....:.::|.||
  Fly   676 AQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECE-ILQTEVRMRDEQIREL 739

Human   650 KAVMEGIKMEHQLELGNLQAKHDL-----------ETAMHVKEKEALREKLQEAQ---------- 693
            ...::.:..:..::..:..|..|:           .|.:...|||.::.|.|.|:
  Fly   740 NQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEK 804

Human   694 -----EELAGLQRHWR---------AQLEVQASQHRL-----ELQEAQDQRRDAELRVHELE--- 736
                 ::||..::..|         .|||.::.:.:|     ||::.|.::.::|:.:.|::
  Fly   805 QISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQN 869

Human   737 -KLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGK-----------QEVESLREKLLV 789
             :.|.|.....::::.|::|:   |:|.|.:|:||.|..:.|           ||::.|:.|...
  Fly   870 TQKDFELVESGESLKKLQQQL---EQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAE 931

Human   790 AENRLQAVEALCSSQHTHMIESNDISEETI---------------RTKETVEGLQDKLNKRDKEV 839
            :|:.|:.|:............|.:...:|:               .|:..::..|..|..:.|::
  Fly   932 SESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQL 996

Human   840 ---------------------------------------TALTSQTEML---------------- 849
                                                   |.:.|:|:.|
  Fly   997 EAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAE 1061

Human   850 -RAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHD--ASGQLVLI------SQELLRK 905
             ||:.|.|:.|.|.....:.|.|:.:|...:.|.|...|..|  |:|...|.      |||:|:|
  Fly  1062 SRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQK 1126

Human   906 ERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEK-SLSDQ 969
            |:.|.|||..|.::..         |:...|||...||:..::.|:.|:|::|....|. .||..
  Fly  1127 EKELQELRQQLQDSQD---------SQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTG 1182

Human   970 RRYSLIDRSSAPEL--LRLQH-QLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSAN 1031
            .:.::.|.....|:  ..||| :.|::|||.:.|     .::.|:||::..  .|.....:...:
  Fly  1183 TQTTIKDLQERLEITNAELQHKEKMASEDAQKIA-----DLKTLVEAIQVA--NANISATNAELS 1240

Human  1032 GIHQQDKAQKQEDKH 1046
            .:.:..:|:|.|..|
  Fly  1241 TVLEVLQAEKSETNH 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLIP2	NP_003379.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71		17/67 (25%)
		CAP_GLY	81..145	CDD:366568	35/63 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..162		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..215		2/19 (11%)
		CAP_GLY	221..285	CDD:366568	40/66 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..339		7/25 (28%)
		Smc	<357..971	CDD:224117	172/847 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1018..1046		4/27 (15%)
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039	20/89 (22%)
		CAP_GLY	125..189	CDD:396049	35/63 (56%)
		CAP_GLY	239..306	CDD:396049	40/66 (61%)
		SMC_prok_B	<546..912	CDD:274008	80/386 (21%)
		Smc	734..1591	CDD:224117	111/541 (21%)
		SHE3	1502..1702	CDD:293683
		CLIP1_ZNF	1773..1789	CDD:406934
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2817
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	406	1.000	Inparanoid score	I1898
Isobase	1	0.950	-	0	Normalized mean entropy	S5390
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1110101at2759
OrthoFinder	1	1.000	-	-		FOG0002895
OrthoInspector	1	1.000	-	-		otm40362
orthoMCL	1	0.900	-	-		OOG6_104816
Panther	1	1.100	-	-	O	PTHR18916
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1398
SonicParanoid	1	1.000	-	-		X2251
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.810