Protein Alignment EIF4H and eIF4B

DIOPT Version :9

• Sequence 1: NP_071496.1
• Gene: EIF4H / 7458
• HGNCID: 12741
• Length: 248
• Species: Homo sapiens
• Sequence 2: NP_001015319.1
• Gene: eIF4B / 3355041
• FlyBaseID: FBgn0020660
• Length: 459
• Species: Drosophila melanogaster
• Alignment Length: 262
• Identity: 68/262 - (25%)
• Similarity: 119/262 - (45%)
• Gaps: 54/262 - (20%)

Human    36 LPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVR-DKDTDKFKGFCYVEFDEVDSLKEAL 99
            :|.:.|:.||:.||||:..:.|:...|:.:::.|:||.| |.:..:.:||.|||.:..:.|...|
  Fly    74 IPHKAPFIAYINNLPFDANEDDLYEFFEGINLISLRLPREDGENGRSRGFGYVELENREDLIHVL 138

Human   100 TYDGALLGDRSLRVDIA-----EGRKQDKGGF-GFRKGGPDDRGMGSSRESRGGWDSRDDFNSGF 158
            :.....:..|.:|::::     :.|::....| ||...| |:|..|:.|.......|...::|.|
  Fly   139 SLPDPSIKGRRIRIELSNENDQQSRQKSNRRFDGFGNNG-DNRDSGNWRRDSQNNGSNFGYSSNF 202

Human   159 -------------RDDFL---GGRGGSRPGDRRTGP------PMGSRFRDGPPLRGSNMDFREPT 201
                         |||..   ..|..:||....|.|      .:..::|:| .::.::...||.|
  Fly   203 ERSFNRERKSLPDRDDVNTPGSWRTSARPQSIDTSPTRREVEQVSEKYREG-RVKIADRYSREET 266

Human   202 EEERAQRPRLQLKPRTVATP----------------LNQVANPNSA-IFGGARP-----RE-EVV 243
            .:...:||:|.|||||:..|                |::....:|. :||.|:|     || |:.
  Fly   267 SKVEEERPKLNLKPRTLPLPDVKTIEFEKCDVDEFNLDKQGGTSSLNVFGSAKPVDTAARELEIE 331

Human   244 QK 245
            |:
  Fly   332 QR 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EIF4H	NP_071496.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41		1/4 (25%)
		RRM_eIF4H	37..120	CDD:409835	24/88 (27%)
		SF-CC1	<40..>227	CDD:273721	58/231 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..248		43/171 (25%)
		HHV-1 Vhs binding site	137..157		3/19 (16%)
eIF4B	NP_001015319.1	RRM	<72..268	CDD:223796	49/195 (25%)
		RRM_eIF4B	79..155	CDD:240848	23/75 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1530583at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1292
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950