DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrrc15 and Fili

DIOPT Version :9

Sequence 1:	NP_083249.1	Gene:	Lrrc15 / 74488	MGIID:	1921738	Length:	579	Species:	Mus musculus
Sequence 2:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	585	Identity:	137/585 - (23%)
Similarity:	226/585 - (38%)	Gaps:	138/585 - (23%)

- Green bases have known domain annotations that are detailed below.

Mouse    25 CPSECTC---SRASQVECTGAQIVAMPSPLPWNAMSLQILNTHITELPEDKFLNISALIALKMEK 86
            |||:|.|   ...|:..|..|.:..:|..|.                ||.|::|::.
  Fly    42 CPSKCQCLGGEANSRALCVDAALEDVPIQLN----------------PETKYINLTV-------- 82

Mouse    87 NELANI---MPGAFRNLGSLRHLSLANNKLKNLPVRLFQDVNNLETLLLSNNQLVQIQPAQFSQF 148
            |.:..:   :|...:    |..|.|:.|.::.|..:.|:..:.|.||.||.|.:..:....|...
  Fly    83 NRIRTLEFSLPFYMK----LEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGL 143

Mouse   149 SNLKELQLYGNNLEYIPEGVFDHLVGLTKLNLGNNGFTHLSPRVFQHLGNLQVLRLYENRLSDIP 213
            :||..|.|..|.:|.:.......|..|.:|:|.||....|....|:.:..|:||....|||.|:|
  Fly   144 TNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVP 208

Mouse   214 MGTFDALGNLQELALQENQIGTLSPGLFHNNRNLQRLYLSNNHISHLPPGIFMQLPHLNKLTLFG 278
                                   :..|:|.:. |:.|.:|.|.:..:....|..|..|..|::.|
  Fly   209 -----------------------ASNLWHLHA-LKSLDMSLNLVEFVRNDSFEGLKELLALSVQG 249

Mouse   279 NSLKELSPGVFGPMPNLRELWLYNNHITSLPDNAFSHLNQLQVLILSHNQLSYISPGAFNGLTNL 343
            |.:.||....|..:.:|:.|.|.:|::|.:|....|.|:.|..|.|..|:.|.:...||..|.:|
  Fly   250 NVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHL 314

Mouse   344 RELSL-HTNALQDLDGNVFRSLANLRNVSLQNN-RLRQLPGSIFANVNGLMTIQLQNNNLENLPL 406
            |||.| ..:.||.:|...|....:|:.:.|.|| :|..:|..:|.....::.:.:|:|:|:.|..
  Fly   315 RELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYS 379

Mouse   407 GIFDHLGNLCELRLYDNPWRCDSNILPLHDWLILNRARLGTDTLPVCSSPASVRGQSLVIINVNF 471
            ..|. :..|.:|.|.|||.:|:.::|    ||    .||.|.                     ||
  Fly   380 AQFP-VDQLQKLYLGDNPLQCNCSLL----WL----WRLVTG---------------------NF 414

Mouse   472 PGPSVQGPETPEVSSYPDTSSYPDSTSISSTTEITRSTDDD-------------YTDLNTIEP-- 521
            .|.. .|.|.....:....:...|...::.......||||.             ...|:|.||
  Fly   415 EGVD-PGMEHAAGGAVAALAKEADDEELADEATAVASTDDGVAALAAYIAEQHIVNALHTTEPSA 478

Mouse   522 ------IDDRNT--------------WG---------MTDAQSGLAIAAIVIGIIALACSLAACI 557
                  ..:||:              |.         :|.::..:...|.::.::   |::..|:
  Fly   479 YELATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLTMSEGEITCPAHIVTVV---CAVITCL 540

Mouse 558 557
Fly 541 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrc15	NP_083249.1	LRR 1	54..75		3/20 (15%)
		leucine-rich repeat	58..78	CDD:275380	4/19 (21%)
		LRR 2	78..99		2/23 (9%)
		PLN00113	82..>401	CDD:215061	86/323 (27%)
		LRR 3	102..123		6/20 (30%)
		leucine-rich repeat	103..126	CDD:275380	6/22 (27%)
		LRR 4	126..147		7/20 (35%)
		leucine-rich repeat	127..150	CDD:275380	7/22 (32%)
		LRR 5	150..171		6/20 (30%)
		leucine-rich repeat	151..174	CDD:275380	6/22 (27%)
		LRR 6	174..195		7/20 (35%)
		leucine-rich repeat	175..198	CDD:275380	7/22 (32%)
		LRR 7	198..219		8/20 (40%)
		leucine-rich repeat	199..222	CDD:275380	8/22 (36%)
		LRR 8	222..243		1/20 (5%)
		leucine-rich repeat	223..246	CDD:275380	2/22 (9%)
		LRR 9	246..267		5/20 (25%)
		leucine-rich repeat	247..270	CDD:275380	6/22 (27%)
		LRR 10	270..291		7/20 (35%)
		leucine-rich repeat	271..294	CDD:275380	7/22 (32%)
		LRR 11	294..315		6/20 (30%)
		leucine-rich repeat	295..318	CDD:275380	8/22 (36%)
		LRR 12	318..339		7/20 (35%)
		leucine-rich repeat	319..342	CDD:275380	8/22 (36%)
		LRR 13	342..363		9/21 (43%)
		leucine-rich repeat	343..364	CDD:275380	9/21 (43%)
		LRR 14	366..387		7/21 (33%)
		leucine-rich repeat	367..387	CDD:275380	7/20 (35%)
		LRR 15	390..411		5/20 (25%)
		leucine-rich repeat	391..412	CDD:275380	5/20 (25%)
		LRRCT	423..>462	CDD:214507	9/38 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..509		3/32 (9%)
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	4/29 (14%)
		leucine-rich repeat	98..121	CDD:275380	6/22 (27%)
		LRR_8	120..180	CDD:404697	19/59 (32%)
		leucine-rich repeat	122..145	CDD:275380	7/22 (32%)
		leucine-rich repeat	146..169	CDD:275380	6/22 (27%)
		LRR	<161..>354	CDD:227223	61/216 (28%)
		leucine-rich repeat	170..193	CDD:275380	7/22 (32%)
		leucine-rich repeat	194..217	CDD:275380	10/45 (22%)
		leucine-rich repeat	218..265	CDD:275380	13/46 (28%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		leucine-rich repeat	314..338	CDD:275380	9/23 (39%)
		LRR_8	337..397	CDD:404697	17/60 (28%)
		leucine-rich repeat	339..360	CDD:275380	7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010