Protein Alignment VRK2 and Asator

DIOPT Version :9

• Sequence 1: NP_001123952.1
• Gene: VRK2 / 7444
• HGNCID: 12719
• Length: 508
• Species: Homo sapiens
• Sequence 2: NP_651924.2
• Gene: Asator / 43794
• FlyBaseID: FBgn0039908
• Length: 1349
• Species: Drosophila melanogaster
• Alignment Length: 494
• Identity: 126/494 - (25%)
• Similarity: 209/494 - (42%)
• Gaps: 114/494 - (23%)

Human    28 QWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIER 92
            :|.:.:|||.||||.||........|:.|   :|||......  ..||....|.||...|:.:.|
  Fly   172 RWKVVRKIGGGGFGEIYEGQDLITREQVA---LKVESARQPK--QVLKMEVAVLKKLQGKEHVCR 231

Human    93 KQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKI--SGQNGTFKKSTVLQLGIRMLDVLE 155
                      |.|.|    :...:.::||:..|.:|.::  :...|.|..||.|:||:::|..:|
  Fly   232 ----------FIGCG----RNDRFNYVVMQLQGKNLAELRRAQPRGAFSLSTTLRLGLQILKAIE 282

Human   156 YIHENEYVHGDIKAANLLLG---YKNPDQVYLADYGLSYRY--------CPNGNHKQYQENPRKG 209
            .||...::|.|||.:|..:|   | |..:||:.|:||:.:|        ||..         ..|
  Fly   283 SIHSVGFLHRDIKPSNFSVGRLPY-NCRRVYMLDFGLARQYTTGTGEVRCPRA---------AAG 337

Human   210 HNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQS 274
            ..||:.:.|::||:...:.|..|:..|.|.::.::.|:||| :.:||...|...|......:
  Fly   338 FRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVNGQLPW-RKIKDKEQVGLTKEKYDHRI--- 398

Human   275 VLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTP-N 338
            :||..||     ::.|||....||.|.::|:|..|          :|..:...|.:.:....| :
  Fly   399 LLKHLPS-----DLKQFLEHIQSLTYGDRPDYAML----------IGLFERCMKRRGVKESDPYD 448

Human   339 SQKVDSQKAATKQVNKAHNRLIEKK---VHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRR 400
            .:||||  .|...::...|..|..|   :|...:..:.|.             :|.:..|..|:|
  Fly   449 WEKVDS--TAIGNISATGNPSIPIKSDYMHGNITQMTVAA-------------SNASGTEYIRKR 498

Human   401 QKYQESQ----EPLN---EVNSFPQKISYTQFPNSFYEP---------HQDFTSPDIFKKSRSPS 449
            .:.:.:.    :|||   :|:......|..|......||         :|:.||..:.::|
  Fly   499 AEIETAHITATDPLNIKEKVDKNCNATSLAQPAKGSGEPMVQHGNAANNQNITSKGLQQQS---- 559

Human   450 WYKYTSTVS-TGITDLESSTGLWPTI-----SQFTLSEE 482
                |.|.| ..|.:::|:    |::     .|:|..||
  Fly   560 ----TLTNSQVAIANIQSA----PSMIEREDVQYTKLEE 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VRK2	NP_001123952.1	STKc_VRK2	16..314	CDD:271025	87/298 (29%)
		SPS1	29..421	CDD:223589	108/415 (26%)
		Interaction with MAP3K7. /evidence=ECO:0000269|PubMed:17709393	397..508		24/108 (22%)
Asator	NP_651924.2	STKc_TTBK	172..433	CDD:270919	88/308 (29%)
		S_TKc	173..414	CDD:214567	81/278 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810