Protein Alignment VRK2 and dco

DIOPT Version :10

• Sequence 1: NP_006287.2
• Gene: VRK2 / 7444
• HGNCID: 12719
• Length: 508
• Species: Homo sapiens
• Sequence 2: NP_524602.1
• Gene: dco / 43673
• FlyBaseID: FBgn0002413
• Length: 440
• Species: Drosophila melanogaster
• Alignment Length: 392
• Identity: 119/392 - (30%)
• Similarity: 184/392 - (46%)
• Gaps: 51/392 - (13%)

Human    26 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVE--YQENGPLFSELKFYQRVAKKDCIKK 88
            ||::.||:|||||.||.|||....|..|:.|   :|:|  ..::..|..|.|||:.:.
  Fly     6 GNKYRLGRKIGSGSFGDIYLGTTINTGEEVA---IKLECIRTKHPQLHIESKFYKTMQ------- 60

Human    89 WIERKQLDYLGIP--LFYGSGLTEFKGRSYRFMVMERLGIDLQKI-SGQNGTFKKSTVLQLGIRM 150
                   ..:|||  ::.||     :| .|..||||.||..|:.: :..:..|...|||.|..:|
  Fly    61 -------GGIGIPRIIWCGS-----EG-DYNVMVMELLGPSLEDLFNFCSRRFSLKTVLLLADQM 112

Human   151 LDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLS--YRYCPNGNHKQYQENPRKGHNG 212
            :..::|||..:::|.|||..|.|:|. |..:.||:.|:||:  :|...:..|..|:||  |...|
  Fly   113 ISRIDYIHSRDFIHRDIKPDNFLMGLGKKGNLVYIIDFGLAKKFRDARSLKHIPYREN--KNLTG 175

Human   213 TIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDE--LPQSV 275
            |..:.|::.|.|:..|||.|:|.|||.::.:..|.||| |.||  .|.:..|...:.|  |..|:
  Fly   176 TARYASINTHLGIEQSRRDDLESLGYVLMYFNLGALPW-QGLK--AANKRQKYERISEKKLSTSI 237

Human   276 L---KWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLG-PLDFSTKGQSINVHT 336
            :   |..||     |...:|.....:.:|::|:|..|:|:.......|| ..|:......:....
  Fly   238 VVLCKGFPS-----EFVNYLNFCRQMHFDQRPDYCHLRKLFRNLFHRLGFTYDYVFDWNLLKFGG 297

Human   337 P-NSQKV-DSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRR 399
            | |.|.: .:|..|..|.  .|:.:......:..:|.|....:..|....:|.....|||:..:.
  Fly   298 PRNPQAIQQAQDGADGQA--GHDAVAAAAAVAAAAAASSHQQQQHKVNAALGGGGGSAAQQQLQG 360

Human   400 RQ 401
            .|
  Fly   361 GQ 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VRK2	NP_006287.2	STKc_VRK2	16..314	CDD:271025	101/300 (34%)
		Interaction with MAP3K7. /evidence=ECO:0000269|PubMed:17709393	397..508		1/5 (20%)
dco	NP_524602.1	STKc_CK1_delta_epsilon	8..282	CDD:271027	100/306 (33%)