DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VRK2 and ball

DIOPT Version :9

Sequence 1:	NP_001123952.1	Gene:	VRK2 / 7444	HGNCID:	12719	Length:	508	Species:	Homo sapiens
Sequence 2:	NP_651508.1	Gene:	ball / 43228	FlyBaseID:	FBgn0027889	Length:	599	Species:	Drosophila melanogaster

Alignment Length:	462	Identity:	168/462 - (36%)
Similarity:	244/462 - (52%)	Gaps:	46/462 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     5 RNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGP 69
            :::.||:|....||.|..|:...||.:|..||.||||.||.|....:...||  |||.|...|||
  Fly    23 KSKLYKMPEKVKEGTVFTDLAKGQWRIGPSIGVGGFGEIYAACKVGEKNYDA--VVKCEPHGNGP 85

Human    70 LFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ 134
            ||.|:.||.|.||.:.||:::::..|..||:|....:|..|..|..:||:||.|.|.||.|...|
  Fly    86 LFVEMHFYLRNAKLEDIKQFMQKHGLKSLGMPYILANGSVEVNGEKHRFIVMPRYGSDLTKFLEQ 150

Human   135 NG-TFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYK--NPDQVYLADYGLSYRYCPN 196
            || ...:.||.:|.|:||||.:|:|.|.|||.|:||||:|||.:  ...|.||.|:||:..:...
  Fly   151 NGKRLPEGTVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLEKGGAAQAYLVDFGLASHFVTG 215

Human   197 GNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPW--EQNLKDPVA 259
                .::.:|:|.||||||:||.|||.||. :||:|:|||||.::.||..:|||  ::.|..|..
  Fly   216 ----DFKPDPKKMHNGTIEYTSRDAHLGVP-TRRADLEILGYNLIEWLGAELPWVTQKLLAVPPK 275

Human   260 VQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNY--------QALKKILNPH 316
            ||.||...:|.:.:|:....|.|.. ..|..|:.....|.::::|:|        .|||::..|:
  Fly   276 VQKAKEAFMDNIGESLKTLFPKGVP-PPIGDFMKYVSKLTHNQEPDYDKCRSWFSSALKQLKIPN 339

Human   317 GIPLGPLDFSTKGQSI---NVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKV 378
            .   |.|||..|.|:.   |:..|.:.|..:.:.|.|..:...|..:::|:.:....|
  Fly   340 N---GDLDFKMKPQTSSNNNLSPPGTSKAATARKAKKIDSPVLNSSLDEKISASEDDE------- 394

Human   379 QKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEV-NSFP--QKISYTQFPNSFYEPHQDFTSPD 440
            ::|||   ....:.|::.|...:..:.|  ||..| :|.|  ||...|: |.|  .|.:..| |.
  Fly   395 EEEEK---SHRKKTAKKVTPSARNAKVS--PLKRVADSSPPSQKRVKTE-PKS--TPRERAT-PK 450

Human   441 IFKKSRS 447
            ...|.||
  Fly   451 ASPKPRS 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VRK2	NP_001123952.1	STKc_VRK2	16..314	CDD:271025	128/310 (41%)
		SPS1	29..421	CDD:223589	151/410 (37%)
		Interaction with MAP3K7. /evidence=ECO:0000269\|PubMed:17709393	397..508		18/54 (33%)
ball	NP_651508.1	STKc_VRK	36..328	CDD:270917	124/299 (41%)
		SPS1	47..432	CDD:223589	149/407 (37%)
		Pol_alpha_B_N	<399..>502	CDD:285602	20/68 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149474
Domainoid	1	1.000	157	1.000	Domainoid score	I4156
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3210
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D371612at33208
OrthoFinder	1	1.000	-	-		FOG0002984
OrthoInspector	1	1.000	-	-		otm40438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11909
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4687
SonicParanoid	1	1.000	-	-		X1730
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.890