Protein Alignment VRK1 and ball

DIOPT Version :9

• Sequence 1: XP_006720310.1
• Gene: VRK1 / 7443
• HGNCID: 12718
• Length: 420
• Species: Homo sapiens
• Sequence 2: NP_651508.1
• Gene: ball / 43228
• FlyBaseID: FBgn0027889
• Length: 599
• Species: Drosophila melanogaster
• Alignment Length: 458
• Identity: 170/458 - (37%)
• Similarity: 247/458 - (53%)
• Gaps: 61/458 - (13%)

Human     1 MPRV----KAAQAGRQSSAKR------HLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLAD 55
            ||||    .||.|.:..|||:      .:.|:...|.:.||:||.:|::|..||.||||.||.|.
  Fly     1 MPRVAKPKAAAPAKKVVSAKKAKSKLYKMPEKVKEGTVFTDLAKGQWRIGPSIGVGGFGEIYAAC 65

Human    56 MNSSESVGS---DAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSG 117
                 .||.   ||  |||.||..|||||.|:.||.|.||.|.|:::::...||.||:|....:|
  Fly    66 -----KVGEKNYDA--VVKCEPHGNGPLFVEMHFYLRNAKLEDIKQFMQKHGLKSLGMPYILANG 123

Human   118 LHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASN 182
            ..:.||:.:||::|.|:||||.|..|.|.||....||.:|::::||:.:|:|.:.|||.|:||:|
  Fly   124 SVEVNGEKHRFIVMPRYGSDLTKFLEQNGKRLPEGTVYRLAIQMLDVYQYMHSNGYVHADLKAAN 188

Human   183 LLLNYK--NPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLE 245
            :||..:  ...|.||||:|||..:    |..::|.|||:.|:||||:||.|||.|| |:||.|||
  Fly   189 ILLGLEKGGAAQAYLVDFGLASHF----VTGDFKPDPKKMHNGTIEYTSRDAHLGV-PTRRADLE 248

Human   246 ILGYCMIQWLTGHLPW--EDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKL 308
            ||||.:|:||...|||  :..|..|..|:.:|..:.:||...:...|| |..|..|..:|:.|..
  Fly   249 ILGYNLIEWLGAELPWVTQKLLAVPPKVQKAKEAFMDNIGESLKTLFP-KGVPPPIGDFMKYVSK 312

Human   309 LDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSV----VENGGLK----AKTITKKRKKEIEES 365
            |.:.::|.|:..|......||.:...::|.||..:    ..|..|.    :|..|.::.|:|
  Fly   313 LTHNQEPDYDKCRSWFSSALKQLKIPNNGDLDFKMKPQTSSNNNLSPPGTSKAATARKAKKI--- 374

Human   366 KEPGVEDTEWSNTQTEEAIQTR--SEESQGAIHRSMSQPEASSSS-----------YDSS-RTRK 416
                  |:...|:..:|.|...  .||.:...||..:..:.:.|:           .||| .::|
  Fly   375 ------DSPVLNSSLDEKISASEDDEEEEEKSHRKKTAKKVTPSARNAKVSPLKRVADSSPPSQK 433

Human   417 RVQ 419
            ||:
  Fly   434 RVK 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VRK1	XP_006720310.1	STKc_VRK1	26..326	CDD:271024	133/306 (43%)
		S_TKc	37..293	CDD:214567	119/262 (45%)
ball	NP_651508.1	STKc_VRK	36..328	CDD:270917	133/304 (44%)
		SPS1	47..432	CDD:223589	151/406 (37%)
		Pol_alpha_B_N	<399..>502	CDD:285602	9/38 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149477
Domainoid	1	1.000	157	1.000	Domainoid score	I4156
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3210
Isobase	1	0.950	-	0	Normalized mean entropy	S2828
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D371612at33208
OrthoFinder	1	1.000	-	-		FOG0002984
OrthoInspector	1	1.000	-	-		otm40438
orthoMCL	1	0.900	-	-		OOG6_106246
Panther	1	1.100	-	-	O	PTHR11909
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4687
SonicParanoid	1	1.000	-	-		X1730
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.740