Protein Alignment TRPV1 and nan

DIOPT Version :10

• Sequence 1: NP_061197.4
• Gene: TRPV1 / 7442
• HGNCID: 12716
• Length: 839
• Species: Homo sapiens
• Sequence 2: NP_001261833.1
• Gene: nan / 39571
• FlyBaseID: FBgn0036414
• Length: 834
• Species: Drosophila melanogaster
• Alignment Length: 798
• Identity: 190/798 - (23%)
• Similarity: 303/798 - (37%)
• Gaps: 248/798 - (31%)

Human    71 DSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFEAVAQNNCQDLESLLL 135
            |.||.::.:..|:      .||..|.:..|           |..|.::.|.:..         |.
  Fly   108 DYCPEVSEAEYIS------NPTAYRFVCWD-----------LNMRGAVGETILH---------LC 146

Human   136 FLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEIARQTDSLKELVNASYTDSYY 200
            .|..|..|..             |.|.:|..:.      .|:|:|              |....|
  Fly   147 LLNASSLHAD-------------LAKRLLKFYP------KLILDI--------------YMSDEY 178

Human   201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDF-------FKKT-------------KGRPG 245
            .|::.|||||...:.|:|..|::..||||....|.|       |.:|             ....|
  Fly   179 YGESVLHIAIVNEDPAMVKYLLDANADVQERCCGAFMSAEDTKFSRTDSPDHEYVALCPMTNYDG 243

Human   246 F-YFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSM 309
            : |:||.|||.|||.:|....:.:|...   ||...:|:.||||||.||               :
  Fly   244 YVYWGEYPLSFAACLSQEECFRLVLARG---ADPDFQDTNGNTVLHMLV---------------I 290

Human   310 YNEILM------LGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYI--LQREIQEPECRHL 366
            |.:|.|      :|..:|       :.|.:.:|||.|||..|::.:..::  ::|||.
  Fly   291 YEKIEMFDVGYEVGTNIH-------IKNIQNLTPLTLAAKLGRVEMFFHVMSIEREIY------- 341

Human   367 SRKFTEWAYGPVHSSLYDLSCIDT-------CEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQ 424
                  |..|.:..:.|.|..|||       ..|:|||..:.:...   ..|..||...:..||:
  Fly   342 ------WQLGSITCAAYPLLMIDTINEETGNINKDSVLNFVVFGDK---LEHLELLDGVVIDLLK 397

Human   425 DKWDRFVKRIFYFNFLVYCLYMII----------------------------------------- 448
            .|||.|.|..||..|.::.||.:|
  Fly   398 TKWDTFCKSRFYKQFYMFALYFLISLFSFILRPGPDAKDEDEDGANSTTAKSDLYRQNGSDSYHL 462

Human   449 ---------------FTMAAYYRP--VDGLPPF----------KMEKTGDYFRVTGEILSVLGGV 486
                           .....||.|  |:.||.:          .:|......|:..|:|:.:|.:
  Fly   463 HSKRATMTTEYKTFWLNFTEYYDPSEVEVLPAWWESYAQCPLMNLESDLAKLRIMAELLNFVGAI 527

Human   487 YFF--------FRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKE---YVAS 540
            .:.        |.|::.|::.       .:.:.|.::|......|:....|..|.|.|   :|..
  Fly   528 LYLLVALREARFLGLKMFIEN-------LMTAPSRVMFLFSCALMMTIPWLRVSCLTEIDDHVTV 585

Human   541 MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKND 605
            ::......:  .|::.|||:.:|.:.|||.:|::.||.||:.:|:||:.|||.|...:.....|.
  Fly   586 VIMLTTAPY--FLFFCRGFKTVGPFVVMIYRMVMGDLLRFVSIYLVFVMGFSQAFYIIFLTFDNP 648

Human   606 SLPSESTSHRWRGPACRPPDSSYNSLYSTCL-ELFKFTIGMGDLEFTEN-YDFKAVFIILLLAYV 668
            |.|.:..:.      ..|..|...|:.:..| .|..|....|.:..|:: |:.|.:|.:    ::
  Fly   649 SSPEDQDAE------SNPMPSPMESIVAMFLMSLTNFGDYYGAMVSTQHEYEAKILFFL----FM 703

Human   669 ILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMR-KAF----------R 722
            ::..:||:|||||:||.|..||| |.:|.|:.|.|..:|..|:|.....| |.|          |
  Fly   704 VIVSVLLVNMLIAMMGNTYQKIA-EIRNEWQRQWARIVLVVERSVPPAERLKNFMQYSQSMSDGR 767

Human   723 SGKLLQVGYTPDGKDDYR 740
            ...:|::..|.:.|::.:
  Fly   768 RALVLRLNMTEEEKEEMK 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRPV1	NP_061197.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..58
		TRPV1	109..761	CDD:411980	182/760 (24%)
		ANK 1. /evidence=ECO:0000269|PubMed:37117175, ECO:0007744|PDB:8GF8, ECO:0007744|PDB:8GF9, ECO:0007744|PDB:8GFA	111..139		5/27 (19%)
		ANK 2. /evidence=ECO:0000269|PubMed:37117175, ECO:0007744|PDB:8GF8, ECO:0007744|PDB:8GF9, ECO:0007744|PDB:8GFA	154..186		6/31 (19%)
		ANK repeat	155..197	CDD:293786	7/41 (17%)
		ANK repeat	202..232	CDD:293786	13/29 (45%)
		ANK 3. /evidence=ECO:0000269|PubMed:37117175, ECO:0007744|PDB:8GF8, ECO:0007744|PDB:8GF9, ECO:0007744|PDB:8GFA	204..229		10/24 (42%)
		ANK repeat	248..282	CDD:293786	12/33 (36%)
		ANK 4. /evidence=ECO:0000269|PubMed:37117175, ECO:0007744|PDB:8GF8, ECO:0007744|PDB:8GF9, ECO:0007744|PDB:8GFA	250..277		9/26 (35%)
		ANK repeat	284..321	CDD:293786	12/42 (29%)
		ANK 5. /evidence=ECO:0000269|PubMed:37117175, ECO:0007744|PDB:8GF8, ECO:0007744|PDB:8GF9, ECO:0007744|PDB:8GFA	286..322		11/41 (27%)
		ANK 6. /evidence=ECO:0000269|PubMed:37117175, ECO:0007744|PDB:8GF8, ECO:0007744|PDB:8GF9, ECO:0007744|PDB:8GFA	336..359		9/24 (38%)
		ANK 7. /evidence=ECO:0000269|PubMed:37117175, ECO:0007744|PDB:8GF8, ECO:0007744|PDB:8GF9, ECO:0007744|PDB:8GFA	394..416		5/21 (24%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:O35433	644..647		0/2 (0%)
		AD. /evidence=ECO:0000250|UniProtKB:O35433	685..713		11/27 (41%)
		Interaction with calmodulin. /evidence=ECO:0000250|UniProtKB:O35433	768..802
		Required for PIP2-mediated channel inhibition. /evidence=ECO:0000250|UniProtKB:O35433	778..793
nan	NP_001261833.1	TRPV	131..748	CDD:454755	176/730 (24%)
		ANK repeat	138..174	CDD:293786	11/77 (14%)
		ANK repeat	179..229	CDD:293786	17/49 (35%)
		ANK repeat	231..278	CDD:293786	14/49 (29%)
		ANK repeat	280..311	CDD:293786	13/52 (25%)