DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo18b and Mhc

DIOPT Version :9

Sequence 1:NP_083177.2 Gene:Myo18b / 74376 MGIID:1921626 Length:2605 Species:Mus musculus
Sequence 2:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster


Alignment Length:1946 Identity:453/1946 - (23%)
Similarity:843/1946 - (43%) Gaps:440/1946 - (22%)


- Green bases have known domain annotations that are detailed below.


Mouse   524 MEEKQILQDPDRGGQSGDSDQAYEDRWYEAQKVWLV-QKDGFTLATV--LKPDEGTADPPAGRVR 585
            :|:::|           |..:.|:.:    :..|:. :|:|:.|..:  .|.|..:.....|.||
  Fly    21 LEQRRI-----------DQSKPYDSK----KSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVR 70

Mouse   586 LCIDADRTVIEVDEEQVHPANPSELDQAEDLASLVSVNESSVMNTLLQRYRAQLPYTCSGPDLIT 650
                      ::..|:|...||.:.::.||:|.:..:|...|::.|.|||.|:|.||.||...:.
  Fly    71 ----------DIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVA 125

Mouse   651 LQP---QTTTVPSSGKVPRG-RQDGLPAHVTSLAQRAYWALLSQRRDQSIVALGRSGAGKTTCCE 711
            :.|   .........|:.|| |::.:|.|:.:::..||..:|:...:||::..|.||||||...:
  Fly   126 INPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTK 190

Mouse   712 QVLEHL--VGMAGSVD----GRVSVE-KLRATFTVLRAFGCVSTGHSRRATRFAMVMSLDFNATG 769
            :|:.:.  ||.:...|    .:.|:| ::..|..||.|||...|..:..::||...:.:.|..||
  Fly   191 KVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTG 255

Mouse   770 RVTAAQLQTVLLENSRVARQPQGEGNFEVFSQLLAG-----MDVDLRTE--LNLHQMAESSAFGM 827
            ::..|.::|.|||.:||..|...|.::.:|.|:::|     .|:.|.|:  .:.|.:::    |.
  Fly   256 KLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQ----GK 316

Mouse   828 GLWSKPEDKQKAATAFSQLRGAMELLGISEGEQQAIWRVLAAIYHLGAAGACKVGRKQFMR---F 889
            ...:..:|    |..||....|.::||.::.|::.::|:.||:.|:|.....:.||::...   .
  Fly   317 VTVASIDD----AEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGE 377

Mouse   890 EWANHAAEALGCDYEELNTATFKHHLRQIIEQMTSGPQRQGLQDNEACSGLKMTGVECVEGMASG 954
            |.....::..|||..||.....|..::...|.:|.|...|.:.::             :..:..|
  Fly   378 EEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNS-------------IGALCKG 429

Mouse   955 LYQELFVAVVSLINRSFSSHHLSMASIMVVDTPGFQNPRHQGKDRAATFEELCYNYAQERLQLLF 1019
            ::..||..:|...|.:..:.......|.|:|..||:...:.|      ||:||.|:..|:||..|
  Fly   430 VFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNG------FEQLCINFTNEKLQQFF 488

Mouse  1020 YHRTFVSTLERYKEEGIPVPF-----DLPESSPGTTVAVVDQNPSQVHLPAGRGAEDAGGLFWVL 1079
            .|..||...|.||.|||...|     ||        :|.:|.            .|...|:..:|
  Fly   489 NHHMFVLEQEEYKREGIDWAFIDFGMDL--------LACIDL------------IEKPMGILSIL 533

Mouse  1080 DEEVRVQGSSDSTVLERL-------RAAFEKKKEAGAEEPPSMRTCEQPLQCELFHQLGRDPVRY 1137
            :||.....::|.|..|:|       .|.|:|.|      ||  :..:|.....:.|..|  .|.|
  Fly   534 EEESMFPKATDQTFSEKLTNTHLGKSAPFQKPK------PP--KPGQQAAHFAIAHYAG--CVSY 588

Mouse  1138 DLTGWLRRAKPNLAALEAPQILQQSKREELQSLFQARAKLPPVCRAVAGLEGTSQQALHRSRVVR 1202
            ::||||.:.|..|    ...::.|.|:.:.:.|.:..|.       .||..|..:||........
  Fly   589 NITGWLEKNKDPL----NDTVVDQFKKSQNKLLIEIFAD-------HAGQSGGGEQAKGGRGKKG 642

Mouse  1203 RAFASSLAAVKRKAPCAQIKLQMDALISLLRRSRLHFIHCLVPTTVESKAGQRTPSPSQPSGDQG 1267
            ..||:..:|.|.         |:::|::.||.::.||:.|::|..::                  
  Fly   643 GGFATVSSAYKE---------QLNSLMTTLRSTQPHFVRCIIPNEMK------------------ 680

Mouse  1268 VANEPTALDIPALRVQLAGSHILEALRLHRAGYAEHMGLAQFRRRFQVLDPALLKKLDLTSEELD 1332
               :|..:|...:..||..:.:||.:|:.|.|:...|....|:.|::::.|.||:.::      .
  Fly   681 ---QPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVE------K 736

Mouse  1333 ERKVVEELLKTLDLEKKAVAVGHSQVFLKAGVVSRLERQREKLVSRNIVLFQAACRGFLSRQEYK 1397
            ::|..|.::|.:||.:....:|:::||.:|||:.::|..|::.:.:.:...||..||:|||:.:|
  Fly   737 DKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFK 801

Mouse  1398 KLKIRRLATLCIQKNLAVFLKVKDWPWWGLLASLRPLLSSTLGTEQLRAKEEELTLLRQKLQKSE 1462
            ||:.:|:|...:|:||..:|:::.|||:.|...::|||:       :...|:|:..|.:|.:|:|
  Fly   802 KLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLN-------VSRIEDEIARLEEKAKKAE 859

Mouse  1463 N---SRSELRQNTDLLESKI----TDLTSELADERFKGDVACQALE--SERAERLQA-------- 1510
            .   :..::|:..:.|.:|:    |.|...|:.|  ||     ||:  .||..:|.|        
  Fly   860 ELHAAEVKVRKELEALNAKLLAEKTALLDSLSGE--KG-----ALQDYQERNAKLTAQKNDLENQ 917

Mouse  1511 LREVQELKTKYQQVQDALGEVQKQLEEAQQRIQG--------------------------ANLEE 1549
            ||::||..|   |.:||..::.:|.::|.|.|.|                          .||.:
  Fly   918 LRDIQERLT---QEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLND 979

Mouse  1550 KPAGGADEWQMRLDC-AQMENDFLRK---RLQQCEERLDSEMKARTELEQKLGELQSAYEEAKKM 1610
            :.| ..||...:|:. .:|:.:..:|   .||..|::::...|.:.:|||.|.||:.:.|..||:
  Fly   980 EIA-HQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKV 1043

Mouse  1611 AHQLKRKCHHLTWDLEDTRVLLENQQSRNHELEKRQKKFDLQLA--------------------- 1654
            ...:::....:..||:.|:..:.:.:....|||:..::.|.:|:                     
  Fly  1044 RGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIK 1108

Mouse  1655 --QALGESM-----FEKSLREKVSQENNGVRWELGQLQQQLEQ--------------KEQEASKL 1698
              ||..|.:     .|:..|.|..::...:..||.:|.::||:              :|.|.|||
  Fly  1109 ELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKL 1173

Mouse  1699 KQEVERLQGQ-KRELLSCASVGDQGVASLKERVWEL----------------ETNALE------- 1739
            ::::|....| :..|.:.....:..||.:.|:|.:|                :.|.|.       
  Fly  1174 RRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHIT 1238

Mouse  1740 -----QQKIHSQQENTIKQLEQL------------RQRFELEIERMKQMHQ-KDREDQEEELEDV 1786
                 |:||..|.::|:.:::..            ..:.:|.||....:.| ::.|.|..:|..:
  Fly  1239 NEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKI 1303

Mouse  1787 RQSCQKRLRQLEMQLEQEYEEKQVALHEKHDLEGLIGTLCDQIGHRDFDVEKRLRRDLRRTHALL 1851
            :.|...:|...:...::|..|:...|.:..:||..:..|.:|: ..:.:.:..|:|.|.:.:|  
  Fly  1304 KISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQV-EEEAEGKADLQRQLSKANA-- 1365

Mouse  1852 SDVQLLLATIEDSKTSISKEELEKVHSQLEQSEAKCEDAL-----------KTQKVLTADLENMH 1905
             :.|:..:..|....:.| ||||:...:|:...|:.|:.:           ||::.|:.::|::.
  Fly  1366 -EAQVWRSKYESDGVARS-EELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQ 1428

Mouse  1906 SELE------NVTRSKS------------LVDE-----------------QLYRLQ---FERADL 1932
            .|::      |....|.            .||:                 :|:||:   .|..:.
  Fly  1429 LEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQ 1493

Mouse  1933 LKRIDEDQGDLNDLMQKHKDLIAQSAADIGQIQ-----------ELQLQLEET-----KKEKQKL 1981
            |:.:..:..:|.|.::...|.|.:...:|.:|:           |||..|||.     ::|.:.|
  Fly  1494 LEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVL 1558

Mouse  1982 REQLHMAQL------RIQYLEQ------STVERAIVSRQEAIICDLENKTEFQKVQIKRFEVLVI 2034
            |.||.::|:      |||..|:      ...:||:.|.|.::..:.:.|.|..::: |:.|..:.
  Fly  1559 RAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMK-KKLEADIN 1622

Mouse  2035 RLRDSMIKMGEELSRAVKAEAQQRENSQYYQQRLEELKAEMQELAQREEEA-------SRRCMEL 2092
            .|..:       |..|.||.|:.::|.:.|||:|::::..::|..:..::|       .||...|
  Fly  1623 ELEIA-------LDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANAL 1680

Mouse  2093 EKYVEELATVRQTLQTDLETSIRRIADLQAALEEVVSSDSDTESVQTAVDCSSRSGKEGDNVSVI 2157
            :..:||..|:.:........:.:.:||....|.||        |.|.|            ::|..
  Fly  1681 QNELEESRTLLEQADRGRRQAEQELADAHEQLNEV--------SAQNA------------SISAA 1725

Mouse  2158 SSQPEGSLQSWMSCSLSLATDSVRIPSGQSVVSSSFHSPRVSEE-------AGDSERLRTA 2211
            ..:.|..||:..|....|..::..  |.:....:...:.|:::|       |...|:||.|
  Fly  1726 KRKLESELQTLHSDLDELLNEAKN--SEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKA 1784

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo18bNP_083177.2 PHA03247 <55..472 CDD:223021
COG5022 606..2126 CDD:227355 419/1767 (24%)
MYSc_Myo18 625..1361 CDD:276837 195/768 (25%)
CEP170_C 2123..>2365 CDD:373735 20/96 (21%)
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 9/46 (20%)
MYSc 81..777 CDD:214580 205/799 (26%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 195/768 (25%)
Myosin_tail_1 842..1897 CDD:279860 209/989 (21%)
V_Alix_like 1557..1877 CDD:187408 58/258 (22%)
ATP-synt_B <1671..1771 CDD:304375 23/121 (19%)
TMPIT 1739..>1825 CDD:285135 9/48 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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