DRSC/TRiP Functional Genomics Resources

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Protein Alignment VLDLR and mgl

DIOPT Version :10

Sequence 1:NP_003374.3 Gene:VLDLR / 7436 HGNCID:12698 Length:873 Species:Homo sapiens
Sequence 2:NP_572563.3 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster


Alignment Length:817 Identity:304/817 - (37%)
Similarity:418/817 - (51%) Gaps:114/817 - (13%)


- Green bases have known domain annotations that are detailed below.


Human    33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSR--------- 88
            |.|::|:|.|||||...||||.:.||.|||||..||...|.:.:|.|.||:|:|..         
  Fly  2867 CSPNEFRCNNGRCIFKSWKCDHENDCKDGSDELGCVYPPCVDGEFTCANGRCIPQAQVCNGVNDC 2931

Human    89 ------------------------------------WKCDGDPDCEDGSDESPEQCHMRTCRIHE 117
                                                |.||||.||.|.|||.|..|..|||..:.
  Fly  2932 KDNATSDETHERCPMNTTCPANHLKCEKTNICVEPYWLCDGDNDCGDNSDEDPLHCGQRTCPTNS 2996

Human   118 ISCGAHSTQCIPVSWRCDGENDCDSGEDE--ENCGN--ITCSPDEFTCSSGRCISRNFVCNGQDD 178
            ..|..|  :|||.:|.|||::||..|.||  :.|.:  .||..|.|||.:|.||.|.::|:|.:|
  Fly  2997 FRCPNH--RCIPATWYCDGDDDCGDGADEPPDYCKSEGRTCFGDLFTCDNGNCIPRIYICDGDND 3059

Human   179 CSDGSDE---LDCAPPTCGAH-EFQC------STSSCIPISWVCDDDADCSDQSDE--SLEQCG- 230
            |.|.|||   ..|....|... ||.|      ..:.|||..|:||.|.||.|.:||  :|..|. 
  Fly  3060 CLDNSDEDNRHQCNDRKCDEETEFTCVENKSWQRAQCIPKKWICDGDPDCVDGADENTTLHNCAT 3124

Human   231 RQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDE---VNCPSRTCRPDQFECEDGSCIH 292
            :||     |......||:|.||:|.|.||.|.||.||:||   .|...:||...:|.|::..||.
  Fly  3125 QQP-----CGEDMFTCGNGRCINKGWICDHDNDCGDGTDEGKFCNSKYKTCSAQEFTCQNFKCIR 3184

Human   293 GSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHI 357
            ...:|:|..||.|.||||.|...|.....|:|.|.:|:|||.:.|||:..||.|.|||| ..|::
  Fly  3185 NQSRCDGEDDCGDHSDEVGCAKENITCPQGQFACTNGQCIDYNLVCNKYPDCADESDEP-AHCNV 3248

Human   358 NECL-VNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDEC-QNPGICSQICINLKGGYKC 419
            :||. |....|.|.|.|.:.||.|||..|::|: |.|.|.|:||| :.||.|||.|.|..||:.|
  Fly  3249 DECAKVEINQCGHKCVDTLTGYYCDCNEGYKLLADGKACADVDECLEQPGACSQHCSNTPGGFYC 3313

Human   420 ECSRGY---QMDLATGVCKAVGK-EPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA 480
            :|...|   |.|..|  ||...| .|.|||||:..:|.:.::..:|..:.:.|.|.||||.||..
  Fly  3314 KCDETYYERQNDEHT--CKRKDKIPPWLIFTNKYYVRNMSVDGHQYNLMHQDLMNVVALDFDIRE 3376

Human   481 QKLFWADLSQKAIFSA---SIDDKV--GRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA 540
            :.:::.|::.|.||.|   ..||::  .|...:..:.:....||:|||.:.:||.|..||.:.|:
  Fly  3377 EYMYFCDVTAKTIFRAKYGEADDEMPPEREAVIRHDSHGLEGIAIDWVGRKLYWLDRHSKNLDVS 3441

Human   541 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNG--FDRRPLVTADIQWPN 603
            .|||:|||.| .|.:.:|.:|.|.|..|::|::.|...|.|.|.||:|  |.|.......|.|||
  Fly  3442 ELDGSKRKTL-RSGVVDPRAIVVHPGIGYLYFTSWHLQAYIAKMGMDGSNFSRILNWNDGIAWPN 3505

Human   604 GITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVY 668
            .:::|....|:||.|:.|..::..||.|:.|..||...: :.|..||::|:|.:||.|...:|:.
  Fly  3506 ALSIDYFTDRIYWADAHLDYIAYADLEGRHRHTVLSGSK-VPHVFALSLFDDYIYWSDWNLKAIV 3569

Human   669 GANKFTGSELATLVNNLNDAQDIIVYHELVQ-----PSGKNWCEEDMENGGCEYLCLPAP----- 723
            .||||.|:....|.|..:...|:.:.|.|.|     |.|.|       ||||.:|||.||     
  Fly  3570 RANKFHGANYTVLRNTTHRPYDLHINHPLRQLPYTNPCGTN-------NGGCSHLCLIAPPPEST 3627

Human   724 ------QINDHSPKYTCSCPSGYNVEENGRDCQSTAT 754
                  .|.:.:|.:.|:||:.:.:..:.:.|.:..|
  Fly  3628 YLNIEGYIEEGAPIFKCACPNQFYLARDMKTCVANCT 3664

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VLDLRNP_003374.3 LDLa 33..67 CDD:238060 20/33 (61%)
LDLa 71..103 CDD:197566 16/76 (21%)
Ldl_recept_a 111..149 CDD:395011 17/39 (44%)
LDLa 154..188 CDD:238060 17/36 (47%)
Ldl_recept_a 192..224 CDD:395011 14/38 (37%)
Ldl_recept_a 237..273 CDD:395011 17/38 (45%)
Ldl_recept_a 276..312 CDD:395011 15/35 (43%)
Ldl_recept_a 320..350 CDD:395011 14/29 (48%)
FXa_inhibition 360..394 CDD:464251 15/35 (43%)
EGF_CA 396..426 CDD:214542 16/33 (48%)
Ldl_recept_b 481..522 CDD:459654 10/45 (22%)
LY 505..547 CDD:214531 14/41 (34%)
Ldl_recept_b 568..608 CDD:459654 15/41 (37%)
LY 592..634 CDD:214531 13/41 (32%)
Ldl_recept_b 655..695 CDD:459654 13/39 (33%)
FXa_inhibition 706..749 CDD:464251 14/53 (26%)
mglNP_572563.3 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:469594
YncE <492..634 CDD:442618
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:464251
YvrE 854..>992 CDD:442613
LY 922..964 CDD:214531
LY 973..1007 CDD:214531
Ldl_recept_a 1188..1223 CDD:395011
LDLa 1227..1259 CDD:197566
LDLa 1268..1303 CDD:238060
LDLa 1308..1343 CDD:238060
LDLa 1356..1387 CDD:238060
LDLa 1391..1423 CDD:197566
LDLa 1435..1469 CDD:197566
FXa_inhibition 1522..1553 CDD:464251
LY 1625..1665 CDD:214531
LY 1667..1711 CDD:214531
Ldl_recept_b 1690..1729 CDD:459654
LY 1712..1754 CDD:214531
LY 1986..2037 CDD:214531
FXa_inhibition 2151..>2179 CDD:464251
LY 2259..2305 CDD:214531
Ldl_recept_b 2326..2366 CDD:459654
LY 2352..2392 CDD:214531
NHL 2579..>2711 CDD:302697
NHL repeat 2593..2622 CDD:271320
NHL repeat 2634..2678 CDD:271320
LY 2671..2713 CDD:214531
LDLa 2867..2901 CDD:238060 20/33 (61%)
LDLa 2906..2941 CDD:238060 7/34 (21%)
LDLa 2950..2983 CDD:238060 10/32 (31%)
LDLa 3034..3066 CDD:197566 16/31 (52%)
LDLa 3080..3115 CDD:197566 13/34 (38%)
LDLa 3128..3159 CDD:238060 15/30 (50%)
LDLa 3170..3204 CDD:238060 14/33 (42%)
LDLa 3210..3242 CDD:197566 14/31 (45%)
FXa_inhibition 3259..3287 CDD:464251 13/27 (48%)
FXa_inhibition 3293..3329 CDD:464251 16/37 (43%)
LY 3362..3394 CDD:214531 13/31 (42%)
LY 3406..3448 CDD:214531 14/41 (34%)
Ldl_recept_b 3468..3511 CDD:459654 15/42 (36%)
LY 3498..3536 CDD:214531 13/37 (35%)
LY 3536..3578 CDD:214531 17/42 (40%)
FXa_inhibition 3607..3659 CDD:464251 16/58 (28%)
LDLa 3663..3696 CDD:238060 1/2 (50%)
LDLa 3705..3739 CDD:238060
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4391 CDD:459654
LY 4374..4417 CDD:214531
NHL repeat 4376..4422 CDD:271320
Blue background indicates that the domain is not in the aligned region.

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